{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:46:12Z","timestamp":1787755572629,"version":"build-2784847793"},"reference-count":79,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,1,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Although cellularity is traditionally assessed morphologically, deep sequencing approaches being used for microorganism detection may be able to provide information about cellularity. We hypothesized that cellularity predicted using CIBERSORTx (Stanford University), a transcriptomic-based cellular deconvolution tool, would differentiate between infectious and non-infectious arthroplasty failure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>CIBERSORTx-derived cellularity profiles of 93 sonicate fluid samples, including 53 from subjects who underwent failed arthroplasties due to periprosthetic joint infection (PJI) (abbreviated for the purpose of this study as PJIF) and 40 from subjects who had undergone non-infectious arthroplasty failure (abbreviated NIAF) that had been subjected to bulk RNA sequencing were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Samples from PJIF and NIAF subjects were differentially clustered by principal component analysis based on the cellularity profile. Twelve of the 22 individual predicted cellular fractions were differentially expressed in the PJIF cases compared with the NIAF cases, including increased predicted neutrophils (mean and standard error, 9.73% \u00b1 1.06% and 0.81% \u00b1 0.60%), activated mast cells (17.12% \u00b1 1.51% and 4.11% \u00b1 0.44%), and eosinophils (1.96% \u00b1 0.37% and 0.42% \u00b1 0.21%), and decreased predicted M0 macrophages (21.33% \u00b1 1.51% and 39.75% \u00b1 2.45%), M2 macrophages (3.56% \u00b1 0.52% and 8.70% \u00b1 1.08%), and regulatory T cells (1.57% \u00b1 0.23% and 3.20% \u00b1 0.34%). The predicted total granulocyte fraction was elevated in the PJIF cases (32.97% \u00b1 2.13% and 11.76% \u00b1 1.61%), and the samples from the NIAF cases had elevated predicted total macrophage and monocyte (34.71% \u00b1 1.71% and 55.34% \u00b1 2.37%) and total B cell fractions (5.89% \u00b1 0.30% and 8.62% \u00b1 0.86%). Receiver operating characteristic curve analysis identified predicted total granulocytes, neutrophils, and activated mast cells as highly able to differentiate between the PJIF cases and the NIAF cases. Within the PJIF cases, the total granulocyte, total macrophage and monocyte, M0 macrophage, and M2 macrophage fractions were differentially expressed in\n                      <jats:italic toggle=\"yes\">Staphylococcus aureus<\/jats:italic>\n                      compared with\n                      <jats:italic toggle=\"yes\">Staphylococcus epidermidis<\/jats:italic>\n                      -associated samples. Within the NIAF cases, the predicted total B cell, na\u00efve B cell, plasma cell, and M2 macrophage fractions were differentially expressed among different causes of failure.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>CIBERSORTx can predict the cellularity of sonicate fluid using transcriptomic data, allowing for the evaluation of the underlying immune response during the PJIF and NIAF cases, without a need to phenotypically assess cell composition.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2106\/jbjs.22.00605","type":"journal-article","created":{"date-parts":[[2022,12,27]],"date-time":"2022-12-27T16:00:21Z","timestamp":1672156821000},"page":"63-73","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":11,"title":["Sonicate Fluid Cellularity Predicted by Transcriptomic Deconvolution Differentiates Infectious from Non-Infectious Arthroplasty Failure"],"prefix":"10.2106","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7230-1078","authenticated-orcid":false,"given":"Cody R.","family":"Fisher","sequence":"first","affiliation":[{"name":"Department of Immunology, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Rochester, Minnesota"},{"name":"Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6507-8085","authenticated-orcid":false,"given":"Jordan E.","family":"Krull","sequence":"additional","affiliation":[{"name":"Department of Immunology, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0192-9594","authenticated-orcid":false,"given":"Aditya","family":"Bhagwate","sequence":"additional","affiliation":[{"name":"Department of Quantitative Sciences, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2269-8318","authenticated-orcid":false,"given":"Thao","family":"Masters","sequence":"additional","affiliation":[{"name":"Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3760-4310","authenticated-orcid":false,"given":"Kerryl E.","family":"Greenwood-Quaintance","sequence":"additional","affiliation":[{"name":"Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2398-1724","authenticated-orcid":false,"given":"Matthew P.","family":"Abdel","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6344-4141","authenticated-orcid":false,"given":"Robin","family":"Patel","sequence":"additional","affiliation":[{"name":"Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota"},{"name":"Division of Public Health, Infectious Diseases and Occupational Medicine, Department of Medicine, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,12,2]]},"reference":[{"issue":"2","key":"bib1-20250430","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1128\/CMR.00111-13","article-title":"Prosthetic joint infection","volume":"27","author":"Tande","year":"2014","journal-title":"Clin Microbiol Rev."},{"issue":"1","key":"bib2-20250430","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.idc.2011.09.011","article-title":"Management and prevention of prosthetic joint infection","volume":"26","author":"Shuman","year":"2012","journal-title":"Infectious Disease Clinics of North America."},{"issue":"17","key":"bib3-20250430","first-page":"1386","article-title":"Prevalence of total hip and knee replacement in the United States","volume":"97","author":"Maradit Kremers","year":"2015","journal-title":"The Journal of Bone and Joint Surgery-American Volume."},{"issue":"6","key":"bib4-20250430","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.berh.2006.08.003","article-title":"Infection and musculoskeletal conditions: prosthetic-joint-associated infections","volume":"20","author":"Zimmerli","year":"2006","journal-title":"Best Practice & Research Clinical Rheumatology."},{"issue":"4","key":"bib5-20250430","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1097\/01.qco.0000235161.85925.e8","article-title":"Infections associated with orthopedic implants","volume":"19","author":"Trampuz","year":"2006","journal-title":"Current Opinion in Infectious Diseases."},{"issue":"4","key":"bib6-20250430","first-page":"780","article-title":"Projections of primary and revision hip and knee arthroplasty in the United States from 2005 to 2030","volume":"89","author":"Kurtz","year":"2007","journal-title":"The Journal of Bone & Joint Surgery."},{"issue":"8","key":"bib7-20250430","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.arth.2012.02.022","article-title":"Economic burden of periprosthetic joint infection in the United States","volume":"27","author":"Kurtz","year":"2012","journal-title":"The Journal of Arthroplasty."},{"issue":"1","key":"bib9-20250430","doi-asserted-by":"crossref","first-page":"E52","DOI":"10.1503\/cjs.004219","article-title":"The economic impact of periprosthetic infection in total hip arthroplasty","volume":"63","author":"Akindolire","year":"2020","journal-title":"Canadian Journal of Surgery."},{"issue":"5","key":"bib10-20250430","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1016\/j.arth.2020.12.005","article-title":"Projected economic burden of periprosthetic joint infection of the hip and knee in the United States","volume":"36","author":"Premkumar","year":"2021","journal-title":"The Journal of Arthroplasty."},{"issue":"8","key":"bib11-20250430","doi-asserted-by":"crossref","first-page":"732.e1","DOI":"10.1016\/j.cmi.2016.05.004","article-title":"Time trends in the aetiology of prosthetic joint infections: a multicentre cohort study","volume":"22","author":"Benito","year":"2016","journal-title":"Clinical Microbiology and Infection."},{"issue":"7","key":"bib12-20250430","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1086\/605593","article-title":"Gram-negative prosthetic joint infections: risk factors and outcome of treatment","volume":"49","author":"Hsieh","year":"2009","journal-title":"Clin Infect Dis."},{"issue":"10","key":"bib13-20250430","doi-asserted-by":"crossref","first-page":"923","DOI":"10.5301\/ijao.5000168","article-title":"Epidemiology and new developments in the diagnosis of prosthetic joint infection","volume":"35","author":"Corvec","year":"2012","journal-title":"Int J Artif Organs."},{"issue":"3","key":"bib14-20250430","doi-asserted-by":"crossref","first-page":"e00026-19","DOI":"10.1128\/MMBR.00026-19","article-title":"Staphylococcal biofilm development: structure, regulation, and treatment strategies","volume":"84","author":"Schilcher","year":"2020","journal-title":"Microbiol Mol Biol Rev."},{"issue":"7","key":"bib15-20250430","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/s41579-018-0019-y","article-title":"Implant infections: adhesion, biofilm formation and immune evasion","volume":"16","author":"Arciola","year":"2018","journal-title":"Nat Rev Microbiol."},{"issue":"7","key":"bib16-20250430","first-page":"694","article-title":"[Revision in non-infected total knee arthroplasty: an analysis of 69 consecutive cases]","volume":"86","author":"Bonnin","year":"2000","journal-title":"Rev Chir Orthop Reparatrice Appar Mot."},{"issue":"2","key":"bib17-20250430","doi-asserted-by":"crossref","first-page":"78","DOI":"10.5435\/JAAOS-D-19-00860","article-title":"Reasons for revision: primary total hip arthroplasty mechanisms of failure","volume":"29","author":"Kelmer","year":"2021","journal-title":"J Am Acad Orthop Surg."},{"key":"bib18-20250430","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.jor.2020.12.008","article-title":"Reasons for failure in primary total knee arthroplasty - an analysis of prospectively collected registry data","volume":"23","author":"Mathis","year":"2021","journal-title":"Journal of Orthopaedics."},{"issue":"5","key":"bib19-20250430","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1302\/2046-3758.55.BJR-2016-0086","article-title":"The pathobiology and pathology of aseptic implant failure","volume":"5","author":"Athanasou","year":"2016","journal-title":"Bone & Joint Research."},{"issue":"5","key":"bib20-20250430","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.jor.2019.04.011","article-title":"A systematic review of the causes of failure of revision total hip arthroplasty","volume":"16","author":"Kenney","year":"2019","journal-title":"Journal of Orthopaedics."},{"issue":"suppl_4","key":"bib21-20250430","doi-asserted-by":"crossref","first-page":"138","DOI":"10.2106\/JBJS.F.00609","article-title":"Periprosthetic infection: what are the diagnostic challenges?","volume":"88","author":"Parvizi","year":"2006","journal-title":"Journal of Bone and Joint Surgery."},{"issue":"1","key":"bib22-20250430","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1093\/cid\/cis803","article-title":"Diagnosis and Management of Prosthetic Joint Infection: Clinical Practice Guidelines by the Infectious Diseases Society of Americaa","volume":"56","author":"Osmon","year":"2013","journal-title":"Clinical Infectious Diseases."},{"issue":"2","key":"bib23-20250430","doi-asserted-by":"crossref","first-page":"115","DOI":"10.2106\/JBJS.20.00749","article-title":"Validation of the alpha defensin lateral flow test for periprosthetic joint infection","volume":"103","author":"Deirmengian","year":"2021","journal-title":"Journal of Bone and Joint Surgery."},{"issue":"1","key":"bib24-20250430","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1302\/0301-620X.103B1.BJJ-2020-1381.R1","article-title":"The EBJIS definition of periprosthetic joint infection","volume":"103-B","author":"McNally","year":"2021","journal-title":"The Bone & Joint Journal."},{"issue":"5","key":"bib25-20250430","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1016\/j.arth.2018.02.078","article-title":"The 2018 definition of periprosthetic hip and knee infection: an evidence-based and validated criteria","volume":"33","author":"Parvizi","year":"2018","journal-title":"The Journal of Arthroplasty."},{"key":"bib26-20250430","doi-asserted-by":"crossref","first-page":"146400","DOI":"10.1016\/j.gene.2022.146400","article-title":"Human transcriptomic response to periprosthetic joint infection","volume":"825","author":"Masters","year":"2022","journal-title":"Gene."},{"issue":"11","key":"bib27-20250430","doi-asserted-by":"crossref","first-page":"3501","DOI":"10.1128\/JCM.00834-12","article-title":"Prosthetic joint infection diagnosis using broad-range PCR of biofilms dislodged from knee and hip arthroplasty surfaces using sonication","volume":"50","author":"Gomez","year":"2012","journal-title":"J Clin Microbiol."},{"issue":"9","key":"bib28-20250430","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1093\/cid\/ciy303","article-title":"Identification of prosthetic joint infection pathogens using a shotgun metagenomics approach","volume":"67","author":"Thoendel","year":"2018","journal-title":"Clinical Infectious Diseases."},{"issue":"2","key":"bib29-20250430","first-page":"e20.00067","article-title":"Novel biomarkers for diagnosing periprosthetic joint infection from synovial fluid and serum","volume":"6","author":"Keemu","year":"2021"},{"issue":"12","key":"bib30-20250430","doi-asserted-by":"crossref","first-page":"2664","DOI":"10.1002\/jor.24766","article-title":"Comparative analysis of 23 synovial fluid biomarkers for hip and knee periprosthetic joint infection detection","volume":"38","author":"Sharma","year":"2020","journal-title":"J Orthop Res."},{"issue":"9","key":"bib31-20250430","doi-asserted-by":"crossref","first-page":"358","DOI":"10.3390\/biomedicines8090358","article-title":"High-dimensional analysis of immune cell composition predicts periprosthetic joint infections and dissects its pathophysiology","volume":"8","author":"Korn","year":"2020","journal-title":"Biomedicines."},{"issue":"1","key":"bib32-20250430","doi-asserted-by":"crossref","first-page":"16135","DOI":"10.1038\/s41598-022-20444-9","article-title":"A A 92 protein inflammation panel performed on sonicate fluid differentiates periprosthetic joint infection from non-infectious causes of arthroplasty failure","volume":"12","author":"Fisher","year":"2022","journal-title":"Sci Rep."},{"issue":"7","key":"bib33-20250430","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1056\/NEJMoa061588","article-title":"Sonication of removed hip and knee prostheses for diagnosis of infection","volume":"357","author":"Trampuz","year":"2007","journal-title":"N Engl J Med."},{"issue":"6","key":"bib34-20250430","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1128\/JCM.01686-08","article-title":"Microbiologic diagnosis of prosthetic shoulder infection by use of implant sonication","volume":"47","author":"Piper","year":"2009","journal-title":"J Clin Microbiol."},{"issue":"5","key":"bib35-20250430","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1007\/s11999-008-0609-5","article-title":"Improved detection of biofilm-formative bacteria by vortexing and sonication: a pilot study","volume":"467","author":"Kobayashi","year":"2009","journal-title":"Clinical Orthopaedics & Related Research."},{"issue":"7","key":"bib36-20250430","first-page":"577","article-title":"Expanded CIBERSORTx","volume":"16","author":"Rusk","year":"2019","journal-title":"Nat Methods."},{"issue":"7","key":"bib37-20250430","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/s41587-019-0114-2","article-title":"Determining cell type abundance and expression from bulk tissues with digital cytometry","volume":"37","author":"Newman","year":"2019","journal-title":"Nat Biotechnol."},{"key":"bib38-20250430","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.mimet.2018.10.008","article-title":"Comparative evaluation of cDNA library construction approaches for RNA-Seq analysis from low RNA-content human specimens","volume":"154","author":"Masters","year":"2018","journal-title":"Journal of Microbiological Methods."},{"issue":"1","key":"bib39-20250430","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1186\/1471-2105-15-224","article-title":"MAP-RSeq: Mayo analysis pipeline for RNA sequencing","volume":"15","author":"Kalari","year":"2014","journal-title":"BMC Bioinformatics."},{"issue":"Code Snippet 2","key":"bib42-20250430","doi-asserted-by":"crossref","first-page":"2","DOI":"10.18637\/jss.v079.c02","article-title":"plotROC: a tool for plotting ROC curves","volume":"79","author":"Sachs","year":"2017","journal-title":"Journal of Statistical Software."},{"issue":"6","key":"bib45-20250430","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1097\/COH.0b013e32833ed742","article-title":"Analysis of biomarker data: logs, odds ratios, and receiver operating characteristic curves","volume":"5","author":"Grund","year":"2010","journal-title":"Current Opinion in HIV and AIDS."},{"issue":"9","key":"bib46-20250430","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1097\/JTO.0b013e3181ec173d","article-title":"Receiver operating characteristic curve in diagnostic test assessment","volume":"5","author":"Mandrekar","year":"2010","journal-title":"Journal of Thoracic Oncology."},{"issue":"5-6","key":"bib47-20250430","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1159\/000487756","article-title":"Neutrophils and bacterial immune evasion","volume":"10","author":"Kobayashi","year":"2018","journal-title":"J Innate Immun."},{"issue":"12","key":"bib48-20250430","doi-asserted-by":"crossref","first-page":"2851","DOI":"10.3390\/ijms20122851","article-title":"Mast cells in viral, bacterial, and fungal infection immunity","volume":"20","author":"Piliponsky","year":"2019","journal-title":"International Journal of Molecular Sciences."},{"issue":"1","key":"bib49-20250430","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.ajpath.2015.06.024","article-title":"The role of mast cells in bacterial infection","volume":"186","author":"Johnzon","year":"2016","journal-title":"The American Journal of Pathology."},{"issue":"1","key":"bib50-20250430","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/ar1446","article-title":"Mast cells in inflammatory arthritis","volume":"7","author":"Nigrovic","year":"2005","journal-title":"Arthritis Res Ther."},{"issue":"15","key":"bib51-20250430","doi-asserted-by":"crossref","first-page":"8004","DOI":"10.3390\/ijms22158004","article-title":"Eosinophils and bacteria, the beginning of a story","volume":"22","author":"Ondari","year":"2021","journal-title":"International Journal of Molecular Sciences."},{"issue":"1","key":"bib52-20250430","doi-asserted-by":"crossref","first-page":"e000070","DOI":"10.1136\/rmdopen-2015-000070","article-title":"Eosinophilia predicts poor clinical outcomes in recent-onset arthritis: results from the ESPOIR cohort","volume":"1","author":"Guellec","year":"2015","journal-title":"RMD Open."},{"issue":"3","key":"bib53-20250430","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1002\/jbmr.4489","article-title":"Immune response to persistent Staphylococcus aureus periprosthetic joint infection in a mouse tibial implant model","volume":"37","author":"Sokhi","year":"2022","journal-title":"Journal of Bone and Mineral Research."},{"issue":"1","key":"bib54-20250430","doi-asserted-by":"crossref","first-page":"31","DOI":"10.3390\/pathogens5010031","article-title":"The T cell response to Staphylococcus aureus","volume":"5","author":"Br\u00f6ker","year":"2016","journal-title":"Pathogens."},{"issue":"11","key":"bib55-20250430","doi-asserted-by":"crossref","first-page":"6032","DOI":"10.4049\/jimmunol.171.11.6032","article-title":"Activation of antigen-specific CD8 T cells results in minimal killing of bystander bacteria","volume":"171","author":"Jiang","year":"2003","journal-title":"J Immunol."},{"issue":"6","key":"bib56-20250430","first-page":"918","article-title":"Intracellular Staphylococcus aureus. A mechanism for the indolence of osteomyelitis","volume":"85-B","author":"Ellington","year":"2003","journal-title":"The Journal of Bone and Joint Surgery. British volume."},{"key":"bib57-20250430","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3389\/fcimb.2012.00043","article-title":"Intracellular Staphylococcus aureus: live-in and let die","volume":"2","author":"Fraunholz","year":"2012","journal-title":"Frontiers in Cellular and Infection Microbiology."},{"issue":"10","key":"bib58-20250430","doi-asserted-by":"crossref","first-page":"e00237-18","DOI":"10.1128\/IAI.00237-18","article-title":"Survival of Staphylococcus epidermidis in fibroblasts and osteoblasts","volume":"86","author":"Perez","year":"2018","journal-title":"Infect Immun."},{"issue":"5","key":"bib59-20250430","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1002\/jbmr.3055","article-title":"Evidence of Staphylococcus aureus deformation, proliferation, and migration in canaliculi of live cortical bone in murine models of osteomyelitis","volume":"32","author":"de Mesy Bentley","year":"2017","journal-title":"J Bone Miner Res."},{"issue":"34","key":"bib60-20250430","doi-asserted-by":"crossref","first-page":"5044","DOI":"10.1016\/j.biomaterials.2007.06.035","article-title":"Wear particles, periprosthetic osteolysis and the immune system","volume":"28","author":"Goodman","year":"2007","journal-title":"Biomaterials."},{"issue":"4","key":"bib61-20250430","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1002\/jbm.a.32625","article-title":"Metal is not inert: role of metal ions released by biocorrosion in aseptic loosening\u2014current concepts","volume":"91A","author":"Cadosch","year":"2009","journal-title":"Journal of Biomedical Materials Research Part A."},{"issue":"3","key":"bib62-20250430","doi-asserted-by":"crossref","first-page":"363","DOI":"10.3899\/jrheum.140382","article-title":"The role of innate immunity in osteoarthritis: when our first line of defense goes on the offensive","volume":"42","author":"Orlowsky","year":"2015","journal-title":"J Rheumatol."},{"issue":"12","key":"bib63-20250430","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1002\/jbmr.2735","article-title":"Macrophages: their emerging roles in bone","volume":"30","author":"Sinder","year":"2015","journal-title":"J Bone Miner Res."},{"issue":"10","key":"bib64-20250430","doi-asserted-by":"crossref","first-page":"2999","DOI":"10.3390\/nu12102999","article-title":"Macrophage polarization and osteoporosis: a review","volume":"12","author":"Mu\u00f1oz","year":"2020","journal-title":"Nutrients."},{"key":"bib65-20250430","doi-asserted-by":"crossref","first-page":"58","DOI":"10.3389\/fimmu.2020.00058","article-title":"Osteoimmunology: a current update of the interplay between bone and the immune system","volume":"11","author":"Guder","year":"2020","journal-title":"Front Immunol."},{"issue":"4","key":"bib66-20250430","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1210\/er.2007-0038","article-title":"Osteoimmunology: interactions of the bone and immune system","volume":"29","author":"Lorenzo","year":"2008","journal-title":"Endocrine Reviews."},{"issue":"5","key":"bib67-20250430","doi-asserted-by":"crossref","first-page":"3053","DOI":"10.4049\/jimmunol.162.5.3053","article-title":"Plasma cell development in synovial germinal centers in patients with rheumatoid and reactive arthritis","volume":"162","author":"Kim","year":"1999","journal-title":"J Immunol."},{"issue":"7","key":"bib68-20250430","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1007\/s00296-008-0773-7","article-title":"Infiltrations of plasma cells in synovium are highly associated with synovial fluid levels of APRIL in inflamed peripheral joints of rheumatoid arthritis","volume":"29","author":"Dong","year":"2009","journal-title":"Rheumatol Int."},{"key":"bib69-20250430","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.3389\/fimmu.2018.01924","article-title":"T cells that help B cells in chronically inflamed tissues","volume":"9","author":"Rao","year":"2018","journal-title":"Front Immunol."},{"issue":"2","key":"bib70-20250430","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.immuni.2017.02.006","article-title":"Immunopathogenesis of rheumatoid arthritis","volume":"46","author":"Firestein","year":"2017","journal-title":"Immunity."},{"issue":"6","key":"bib71-20250430","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1002\/jor.23806","article-title":"Human prosthetic joint infections are associated with myeloid-derived suppressor cells (MDSCs): implications for infection persistence","volume":"36","author":"Heim","year":"2018","journal-title":"J Orthop Res."},{"key":"bib72-20250430","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.3389\/fmicb.2017.01401","article-title":"Pathogenic mechanisms and host interactions in Staphylococcus epidermidis device-related infection","volume":"8","author":"Sabat\u00e9 Bresc\u00f3","year":"2017","journal-title":"Front Microbiol."},{"issue":"8","key":"bib73-20250430","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/nrmicro2182","article-title":"Staphylococcus epidermidis\u2014the \u2018accidental\u2019 pathogen","volume":"7","author":"Otto","year":"2009","journal-title":"Nat Rev Microbiol."},{"key":"bib74-20250430","doi-asserted-by":"crossref","first-page":"62","DOI":"10.3389\/fcimb.2012.00062","article-title":"Deciphering mechanisms of staphylococcal biofilm evasion of host immunity","volume":"2","author":"Hanke","year":"2012","journal-title":"Frontiers in Cellular and Infection Microbiology."},{"issue":"11","key":"bib75-20250430","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1158\/2326-6066.CIR-18-0342","article-title":"Immune cell gene signatures for profiling the microenvironment of solid tumors","volume":"6","author":"Nirmal","year":"2018","journal-title":"Cancer Immunology Research."},{"issue":"7","key":"bib76-20250430","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1158\/2326-6066.CIR-18-0500","article-title":"A gene signature predicting natural killer cell infiltration and improved survival in melanoma patients","volume":"7","author":"Cursons","year":"2019","journal-title":"Cancer Immunology Research."},{"issue":"11","key":"bib77-20250430","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.3390\/cells10112935","article-title":"Combined assessment of the tumor\u2013stroma ratio and tumor immune cell infiltrate for immune checkpoint inhibitor therapy response prediction in colon cancer","volume":"10","author":"Ravensbergen","year":"2021","journal-title":"Cells."},{"issue":"12","key":"bib78-20250430","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.4049\/jimmunol.1901133","article-title":"Distinct features of human myeloid cell cytokine response profiles identify neutrophil activation by cytokines as a prognostic feature during tuberculosis and cancer","volume":"204","author":"Devlin","year":"2020","journal-title":"The Journal of Immunology."},{"issue":"3","key":"bib79-20250430","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.joca.2021.12.007","article-title":"Single cell transcriptomics in human osteoarthritis synovium and in silico deconvoluted bulk RNA sequencing","volume":"30","author":"Huang","year":"2022","journal-title":"Osteoarthritis and Cartilage."},{"key":"bib80-20250430","first-page":"1","article-title":"The immune cell landscape in different anatomical structures of knee in osteoarthritis: a gene expression-based study","volume":"2020","author":"Chen","year":"2020","journal-title":"BioMed Research International."},{"key":"bib81-20250430","doi-asserted-by":"crossref","first-page":"423","DOI":"10.3389\/fgene.2020.00423","article-title":"Identification of immune cell landscape and construction of a novel diagnostic nomogram for Crohn\u2019s disease","volume":"11","author":"Chen","year":"2020","journal-title":"Front Genet."},{"issue":"2","key":"bib82-20250430","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.jjcc.2020.08.004","article-title":"Immune cell infiltration landscapes in pediatric acute myocarditis analyzed by CIBERSORT","volume":"77","author":"Kawada","year":"2021","journal-title":"Journal of Cardiology."},{"issue":"6","key":"bib83-20250430","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.chom.2020.04.017","article-title":"Heightened innate immune responses in the respiratory tract of COVID-19 patients","volume":"27","author":"Zhou","year":"2020","journal-title":"Cell Host & Microbe."},{"key":"bib84-20250430","doi-asserted-by":"crossref","first-page":"631226","DOI":"10.3389\/fimmu.2021.631226","article-title":"Inflammation and antiviral immune response associated with severe progression of COVID-19","volume":"12","author":"Zhang","year":"2021","journal-title":"Front Immunol."}],"container-title":["Journal of Bone and Joint Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.2106\/JBJS.22.00605","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T13:45:21Z","timestamp":1787751921000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.2106\/JBJS.22.00605"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,2]]},"references-count":79,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.2106\/jbjs.22.00605","relation":{},"ISSN":["0021-9355","1535-1386"],"issn-type":[{"value":"0021-9355","type":"print"},{"value":"1535-1386","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,2]]}}}