{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:42:07Z","timestamp":1787755327426,"version":"build-2784847793"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","license":[{"start":{"date-parts":[[2023,1,19]],"date-time":"2023-01-19T00:00:00Z","timestamp":1674086400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,5,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Benign bone cysts in children have a high risk of recurrence after bone grafting. The optimal treatment and filling material for these lesions are currently unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We compared cyst recurrence after intralesional curettage and filling with allograft versus bioactive glass (BG-S53P4; Bonalive) in a randomized clinical trial. The volume of recurrent cyst at 2-year follow-up was the primary outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Of 64 eligible children, 51 (mean age, 11.1 years) were randomized to undergo filling of the cyst using morselized allograft (26) or bioactive glass (25). Twelve (46%) of the children in the allograft group and 10 (40%) in the bioactive glass group developed a recurrence (odds ratio [OR] for bioactive glass = 0.79, 95% confidence interval [CI] = 0.25 to 2.56, p = 0.77). The size of the recurrent cyst did not differ between the allograft group (mean, 3.3 mL; range, 0 to 13.2 mL) and the bioactive glass group (mean, 2.2 mL; range, 0 to 16.6 mL, p = 0.43). After adjusting for the type of lesion (aneurysmal bone cyst versus other), bioactive glass also did not prevent larger (&gt;1 mL) recurrent cysts (adjusted OR = 0.42, 95% CI = 0.13 to 1.40, p = 0.16). The Musculoskeletal Tumor Society score improved significantly (p \u2264 0.013) from preoperatively to the 2-year follow-up in both groups (to 28.7 for bioactive glass and 29.1 for bone graft). Four (15%) of the children in the allograft group and 6 (24%) in the bioactive glass group required a reoperation during the follow-up (OR for bioactive glass = 1.74, 95% CI = 0.43 to 7.09, p = 0.50).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Filling with bioactive glass and with allograft in the treatment of benign bone lesions provided comparable results in terms of recurrence and complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence:<\/jats:title>\n                    <jats:p>\n                      Therapeutic\n                      <jats:underline>Level I<\/jats:underline>\n                      . See Instructions for Authors for a complete description of levels of evidence.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.2106\/jbjs.22.00716","type":"journal-article","created":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T13:57:18Z","timestamp":1675346238000},"page":"659-666","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":15,"title":["Allograft Versus Bioactive Glass (BG-S53P4) in Pediatric Benign Bone Lesions"],"prefix":"10.2106","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6275-5140","authenticated-orcid":false,"given":"Johanna","family":"Syv\u00e4nen","sequence":"first","affiliation":[{"name":"Department of Paediatric Surgery and Orthopaedics, Turku University Hospital, University of Turku, Turku, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2868-2985","authenticated-orcid":false,"given":"Willy","family":"Serlo","sequence":"additional","affiliation":[{"name":"Department of Children and Adolescents, Oulu University Hospital and PEDEGO Research Unit Oulu University and MRC Oulu, Oulu, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2374-1306","authenticated-orcid":false,"given":"Jenni","family":"Jalkanen","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery and Orthopaedics, Kuopio University Hospital, University of Kuopio, Kuopio, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0136-6277","authenticated-orcid":false,"given":"Ia","family":"Kohonen","sequence":"additional","affiliation":[{"name":"Medical Imaging Centre of Southwest Finland, Turku University Hospital, Turku, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9114-2204","authenticated-orcid":false,"given":"Arimatias","family":"Raitio","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery and Orthopaedics, Turku University Hospital, University of Turku, Turku, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2220-8008","authenticated-orcid":false,"given":"Yrj\u00e4n\u00e4","family":"Nietosvaara","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery and Orthopaedics, Kuopio University Hospital, University of Kuopio, Kuopio, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5200-3279","authenticated-orcid":false,"given":"Ilkka","family":"Helenius","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Traumatology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,1,19]]},"reference":[{"issue":"1","key":"bib1-20250430","first-page":"S119","article-title":"Bone cysts: unicameral and aneurysmal bone cyst","volume":"101","author":"Mascard","year":"2015","journal-title":"Orthopaedics & Traumatology: Surgery & Research."},{"issue":"27","key":"bib2-20250430","doi-asserted-by":"crossref","first-page":"6756","DOI":"10.1200\/JCO.2005.15.255","article-title":"Aneurysmal bone cyst: a review of 150 patients","volume":"23","author":"Mankin","year":"2005","journal-title":"Journal of Clinical Oncology."},{"issue":"4","key":"bib3-20250430","first-page":"855","article-title":"Treatment of unicameral bone cyst: a comparative study of selected techniques","volume":"92","author":"Hou","year":"2010","journal-title":"The Journal of Bone and Joint Surgery-American Volume."},{"issue":"3","key":"bib4-20250430","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.21873\/invivo.12826","article-title":"Enchondromas of the Hand: Curettage With Autogenous Bone vs. Bioactive Glass S53P4 for Void Augmentation","volume":"36","author":"Lindfors","year":"2022","journal-title":"In Vivo."},{"issue":"363","key":"bib5-20250430","first-page":"176","article-title":"Aneurysmal bone cyst. 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