{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:31:53Z","timestamp":1790829113070,"version":"4.1.0"},"reference-count":47,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,3,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Endocrinopathy is a risk factor for slipped capital femoral epiphysis (SCFE). We aimed to determine (1) the incidence of endocrinopathy-associated SCFE compared with that of non-endocrinopathy-associated SCFE, (2) whether the incidence of SCFE increases with the number of deficient hormones, and (3) the clinical characteristics of endocrinopathy-associated SCFE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We conducted a population-based cohort study using a nationwide database in South Korea. All new diagnoses of endocrinopathy or SCFE between 2002 and 2019 in children born between 2002 and 2005 were identified. The incidence of SCFE was calculated for each type of endocrinopathy. The trend of the incidence of SCFE relative to the number of deficient hormones was analyzed. The male:female ratio was compared between endocrinopathy-associated SCFE and non-endocrinopathy-associated SCFE. For endocrinopathy-associated SCFE, the time between the diagnoses of SCFE and endocrinopathy was evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The incidence of SCFE was higher in children with endocrinopathy than in those without endocrinopathy (37.1\/100,000 versus 9.0\/100,000 children) (relative risk, 4.1 [95% confidence interval, 2.8-6.1]). Among various endocrinopathies, growth hormone deficiency showed the highest incidence of SCFE (583.8\/100,000 children). The Cochran-Armitage test showed a linear trend, with an increased number of deficient hormones being associated with a higher incidence of SCFE (p &lt; 0.001). Male sex was dominant in the non-endocrinopathy-associated SCFE group (73%; 117 of 161), whereas female sex was dominant in the endocrinopathy-associated SCFE group (53%; 16 of 30) (p = 0.009). Twenty-two of the 30 cases of endocrinopathy-associated SCFE were diagnosed after the diagnosis of endocrinopathy, with a median time of 3.6 years between the diagnoses. Six (27%) of these 22 children developed SCFE &gt;5 years after the diagnosis of endocrinopathy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The incidence of SCFE was approximately 4 times higher in children with endocrinopathy than in those without endocrinopathy. The risk of SCFE increased with an increased number of deficient hormones. Long-term monitoring of SCFE occurrence in children with endocrinopathies is strongly recommended.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence:<\/jats:title>\n                    <jats:p>\n                      Diagnostic\n                      <jats:underline>Level III<\/jats:underline>\n                      . See Instructions for Authors for a complete description of levels of evidence.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.2106\/jbjs.23.00790","type":"journal-article","created":{"date-parts":[[2023,12,11]],"date-time":"2023-12-11T14:02:31Z","timestamp":1702303351000},"page":"381-388","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":12,"title":["Incidence and Clinical Characteristics of Slipped Capital Femoral Epiphysis in Patients with Endocrinopathy"],"prefix":"10.2106","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4588-3113","authenticated-orcid":false,"given":"Sunghyun","family":"Hwang","sequence":"first","affiliation":[{"name":"Division of Pediatric Orthopaedics, Seoul National University Children\u2019s Hospital, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2847-2643","authenticated-orcid":false,"given":"Yun Jeong","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Seoul National University Children\u2019s Hospital, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4082-1455","authenticated-orcid":false,"given":"Mi Hyun","family":"Song","sequence":"additional","affiliation":[{"name":"Division of Pediatric Orthopaedics, Seoul National University Children\u2019s Hospital, Seoul, Republic of Korea"},{"name":"Department of Orthopaedics, Seoul National University College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8514-377X","authenticated-orcid":false,"given":"Tae-Joon","family":"Cho","sequence":"additional","affiliation":[{"name":"Division of Pediatric Orthopaedics, Seoul National University Children\u2019s Hospital, Seoul, Republic of Korea"},{"name":"Department of Orthopaedics, Seoul National University College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3875-3529","authenticated-orcid":false,"given":"In Ho","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Seoul National University College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4154-7964","authenticated-orcid":false,"given":"Chang Ho","family":"Shin","sequence":"additional","affiliation":[{"name":"Division of Pediatric Orthopaedics, Seoul National University Children\u2019s Hospital, Seoul, Republic of Korea"},{"name":"Department of Orthopaedics, Seoul National University College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,12,11]]},"reference":[{"key":"bib1-20250430","doi-asserted-by":"crossref","first-page":"486512","DOI":"10.5402\/2011\/486512","article-title":"The epidemiology and demographics of slipped capital femoral epiphysis","volume":"2011","author":"Loder","year":"2011","journal-title":"ISRN Orthop."},{"issue":"3","key":"bib2-20250430","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s11832-013-0493-8","article-title":"Slipped capital femoral epiphysis and its association with endocrine, metabolic and chronic diseases: a systematic review of the literature","volume":"7","author":"Witbreuk","year":"2013","journal-title":"J Child Orthop."},{"issue":"2","key":"bib3-20250430","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2106\/JBJS.RVW.21.00188","article-title":"Slipped capital femoral epiphysis associated with endocrinopathy: a narrative review","volume":"10","author":"Shaw","year":"2022","journal-title":"JBJS Rev."},{"issue":"1","key":"bib4-20250430","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1302\/0301-620X.90B1.19502","article-title":"Changing incidence of slipped capital femoral epiphysis: a relationship with obesity?","volume":"90","author":"Murray","year":"2008","journal-title":"J Bone Joint Surg Br."},{"issue":"2","key":"bib5-20250430","doi-asserted-by":"crossref","first-page":"366","DOI":"10.2106\/JBJS.G.00039","article-title":"Gene expression in slipped capital femoral epiphysis. 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