{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:39:30Z","timestamp":1787755170910,"version":"build-2784847793"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,4,16]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Periprosthetic osteolysis after total ankle arthroplasty (TAA) is a substantial problem. Bone grafting may be beneficial in the treatment of large osteolytic cysts; however, the literature regarding the outcomes of bone grafting is limited. This study analyzed the outcomes of autogenous bone grafting performed for the management of periprosthetic osteolysis following TAA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We retrospectively reviewed 42 ankles (41 Korean patients) that underwent autogenous bone grafting for periprosthetic osteolysis following TAA. Clinical outcomes were evaluated using visual analog scale for pain scores, Ankle Osteoarthritis Scale pain and disability scores, and American Orthopaedic Foot &amp; Ankle Society Ankle-Hindfoot Scale scores. Computed tomography (CT) was performed preoperatively and for at least 2 years postoperatively in order to evaluate the treatment response. Histology, prosthesis survivorship, reoperations, and complications were also evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The mean time to autogenous bone grafting was 64.4 months (range, 10 to 128 months), and the mean follow-up duration after autogenous bone grafting was 70.7 months (range, 24 to 137 months). All clinical scores significantly improved from preoperatively to the last follow-up visit. The mean osteolytic cyst volume improved from 4.8 cm\n                      <jats:sup>3<\/jats:sup>\n                      (range, 1.1 to 19.4 cm\n                      <jats:sup>3<\/jats:sup>\n                      ) to 0.8 cm\n                      <jats:sup>3<\/jats:sup>\n                      (range, 0 to 6.5 cm\n                      <jats:sup>3<\/jats:sup>\n                      ). A Kaplan-Meier survival analysis revealed that TAA with subsequent bone grafting was associated with similar prosthesis survivorship (100% and 85.7% at 5 and 10 years, respectively) but inferior reoperation-free survivorship (93.4% and 68.4% at 5 and 10 years, respectively) compared with TAA without osteolysis or with non-progressive osteolysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Autogenous bone grafting performed for the management of periprosthetic osteolysis after TAA produced favorable clinical and radiographic outcomes. However, there was still a higher risk of subsequent surgery even after successful bone grafting, compared with TAA without osteolysis or with non-progressive osteolysis. Our results suggest that autogenous bone grafting and serial CT scan monitoring over time may prolong the survivorship of TAA prostheses in ankles with periprosthetic osteolysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence:<\/jats:title>\n                    <jats:p>\n                      Therapeutic\n                      <jats:underline>Level IV<\/jats:underline>\n                      . See Instructions for Authors for a complete description of levels of evidence.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.2106\/jbjs.24.00580","type":"journal-article","created":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T14:00:35Z","timestamp":1740492035000},"page":"e33","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Outcomes of Autogenous Bone Grafting for Periprosthetic Osteolysis After Total Ankle Arthroplasty"],"prefix":"10.2106","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0422-7424","authenticated-orcid":false,"given":"Yeo Kwon","family":"Yoon","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwang Hwan","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5763-7860","authenticated-orcid":false,"given":"Dong Woo","family":"Shim","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2585-7273","authenticated-orcid":false,"given":"Wonwoo","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4211-0972","authenticated-orcid":false,"given":"Jae Seok","family":"Chae","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, National Health Insurance Service Ilsan Hospital, Goyang, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7975-6067","authenticated-orcid":false,"given":"Seung Hwan","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0293-9017","authenticated-orcid":false,"given":"Jin Woo","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,2,25]]},"reference":[{"issue":"1","key":"bib1-20250416","doi-asserted-by":"crossref","DOI":"10.1007\/s00264-016-3303-3","article-title":"Total ankle arthroplasty versus ankle arthrodesis for the treatment of end-stage ankle arthritis: a meta-analysis of comparative studies","volume":"41","author":"Kim","year":"2017","journal-title":"Int Orthop."},{"issue":"8","key":"bib2-20250416","doi-asserted-by":"crossref","first-page":"e8","DOI":"10.2106\/JBJS.RVW.17.00182","article-title":"Total Ankle Arthroplasty: A Critical Analysis Review","volume":"6","author":"Cody","year":"2018","journal-title":"JBJS Rev."},{"issue":"5","key":"bib3-20250416","doi-asserted-by":"crossref","DOI":"10.1053\/j.jfas.2019.10.008","article-title":"Clinical Outcomes of Total Ankle Arthroplasty Versus Ankle Arthrodesis for the Treatment of End-Stage Ankle Arthritis in the Last Decade: a Systematic Review and Meta-analysis","volume":"59","author":"Shih","year":"2020","journal-title":"J Foot Ankle Surg."},{"issue":"9","key":"bib4-20250416","doi-asserted-by":"crossref","DOI":"10.1007\/s00264-021-05053-x","article-title":"End-stage ankle osteoarthritis: arthroplasty offers better quality of life than arthrodesis with similar complication and re-operation rates-an updated meta-analysis of comparative studies","volume":"45","author":"Fanelli","year":"2021","journal-title":"Int Orthop."},{"issue":"5","key":"bib5-20250416","doi-asserted-by":"crossref","DOI":"10.1016\/j.fas.2021.05.014","article-title":"Ten-year revision rates of contemporary total ankle arthroplasties equal 22%. 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