{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:26:34Z","timestamp":1788481594843,"version":"build-2803163510"},"reference-count":50,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,4,15]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Transthyretin (TTR) amyloid deposition in the tenosynovium in carpal tunnel syndrome (CTS) is a potential early manifestation of systemic amyloidosis. However, its effects on tenosynovial fibroblasts in CTS remain unclear. We aimed to clarify how wild-type and Val30Met mutant TTR amyloids affect tenosynovial fibroblasts in CTS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Synovial tissue from 20 patients undergoing carpal tunnel release surgery was evaluated for TTR amyloid. Expression of genes related to fibrosis, inflammation, and oxidative stress was compared between TTR-positive and TTR-negative groups. Fibroblasts isolated from TTR-negative patients were treated in vitro with wild-type or Val30Met mutant recombinant TTR. Analyses included quantitative RT-PCR (reverse transcription-polymerase chain reaction), Picrosirius Red staining, MTT assays evaluating cell proliferation, reactive oxygen species (ROS) activity measurements, and senescence-related gene expression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      In TTR-positive tissue, fibrosis-related genes (\n                      <jats:italic toggle=\"yes\">COL1A1, COL3A1, TGFB1,<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">ACTA2<\/jats:italic>\n                      ), the inflammatory mediator\n                      <jats:italic toggle=\"yes\">NFKB1<\/jats:italic>\n                      , and oxidative-stress-related genes (\n                      <jats:italic toggle=\"yes\">KEAP1, NQO1,<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">SOD1<\/jats:italic>\n                      ) were significantly upregulated, whereas\n                      <jats:italic toggle=\"yes\">SOD2<\/jats:italic>\n                      was downregulated. With in vitro treatment in the TTR-negative group, both wild-type and Val30Met TTR increased\n                      <jats:italic toggle=\"yes\">COL3A1, IL6,<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">CXCL8<\/jats:italic>\n                      expression, whereas Val30Met TTR further enhanced\n                      <jats:italic toggle=\"yes\">IL1B<\/jats:italic>\n                      expression. Picrosirius Red staining confirmed increased collagen deposition. MTT assays revealed increased cell viability, indicating enhanced fibroblast proliferation, in both groups. The senescence-related genes\n                      <jats:italic toggle=\"yes\">CDKN2D<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">GADD45A<\/jats:italic>\n                      were downregulated, suggesting enhanced proliferative activity. ROS activity did not differ significantly between groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>TTR amyloid was found to promote expression of fibrosis, inflammation, and oxidative-stress-related genes; inhibit senescence pathways; and enhance collagen deposition and fibroblast proliferation in fibroblasts from patients with CTS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Relevance:<\/jats:title>\n                    <jats:p>CTS with TTR deposition may reflect more than a localized neuropathy, as TTR potentially plays a pathogenic role in CTS development. This finding provides novel insights into the underlying mechanisms of CTS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2106\/jbjs.25.00807","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T19:01:18Z","timestamp":1770922878000},"page":"600-607","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Transthyretin Amyloid May Drive Fibrosis and Proliferation of Tenosynovial Fibroblasts in Carpal Tunnel Syndrome"],"prefix":"10.2106","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9382-0849","authenticated-orcid":false,"given":"Yoshiaki","family":"Yamanaka","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, School of Medicine, University of Occupational and Environmental Health, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2611-0238","authenticated-orcid":false,"given":"Yoshitaka","family":"Tsujimura","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, School of Medicine, University of Occupational and Environmental Health, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0052-4969","authenticated-orcid":false,"given":"Toichiro","family":"Naito","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, School of Medicine, University of Occupational and Environmental Health, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8755-0894","authenticated-orcid":false,"given":"Naohito","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, School of Medicine, University of Occupational and Environmental Health, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4577-5072","authenticated-orcid":false,"given":"Manabu","family":"Tsukamoto","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, School of Medicine, University of Occupational and Environmental Health, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6936-3019","authenticated-orcid":false,"given":"Hitoshi","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, School of Medicine, University of Occupational and Environmental Health, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5354-105X","authenticated-orcid":false,"given":"Yukichi","family":"Zenke","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, School of Medicine, University of Occupational and Environmental Health, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6023-5536","authenticated-orcid":false,"given":"Akinori","family":"Sakai","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, School of Medicine, University of Occupational and Environmental Health, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,2,12]]},"reference":[{"issue":"1","key":"bib1-20260416","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5604\/15093492.1232629","article-title":"Carpal tunnel syndrome: symptoms, causes and treatment options","volume":"19","author":"Zamborsky","year":"2017","journal-title":"Ortop Traumatol Rehabil."},{"issue":"11","key":"bib2-20260416","doi-asserted-by":"crossref","first-page":"8723","DOI":"10.1002\/jcp.26752","article-title":"Effect of estradiol on fibroblasts from postmenopausal idiopathic carpal tunnel syndrome patients","volume":"233","author":"Yamanaka","year":"2018","journal-title":"J Cell Physiol."},{"issue":"1","key":"bib3-20260416","doi-asserted-by":"crossref","first-page":"43","DOI":"10.5271\/sjweh.3835","article-title":"Risk factors of hospitalization for carpal tunnel syndrome among the general working population","volume":"46","author":"Hulkkonen","year":"2020","journal-title":"Scand J Work Environ Health."},{"issue":"11","key":"bib4-20260416","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1016\/j.humpath.2011.03.004","article-title":"High prevalence of wild-type transthyretin deposition in patients with idiopathic carpal tunnel syndrome: a common cause of carpal tunnel syndrome in the elderly","volume":"42","author":"Sekijima","year":"2011","journal-title":"Hum Pathol."},{"issue":"3","key":"bib5-20260416","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.jhsa.2023.10.013","article-title":"Amyloidosis and considerations for the hand surgeon","volume":"49","author":"Brown","year":"2024","journal-title":"J Hand Surg Am."},{"issue":"10","key":"bib6-20260416","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/j.jacc.2022.06.026","article-title":"Screening for cardiac amyloidosis 5 to 15 years after surgery for bilateral carpal tunnel syndrome","volume":"80","author":"Westin","year":"2022","journal-title":"J Am Coll Cardiol."},{"issue":"22","key":"bib7-20260416","doi-asserted-by":"crossref","first-page":"2872","DOI":"10.1016\/j.jacc.2019.04.003","article-title":"Transthyretin amyloid cardiomyopathy: JACC state-of-the-art review","volume":"73","author":"Ruberg","year":"2019","journal-title":"J Am Coll Cardiol."},{"issue":"4","key":"bib8-20260416","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1212\/CPJ.0000000000000640","article-title":"Carpal tunnel syndrome and associated symptoms as first manifestation of hATTR amyloidosis","volume":"9","author":"Karam","year":"2019","journal-title":"Neurol Clin Pract."},{"issue":"3","key":"bib9-20260416","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1002\/ejhf.1742","article-title":"Carpal tunnel syndrome in cardiac amyloidosis: implications for early diagnosis and prognostic role across the spectrum of aetiologies","volume":"22","author":"Milandri","year":"2020","journal-title":"Eur J Heart Fail."},{"issue":"12","key":"bib10-20260416","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1007\/s00392-019-01467-1","article-title":"Carpal tunnel syndrome and spinal canal stenosis: harbingers of transthyretin amyloid cardiomyopathy?","volume":"108","author":"Aus dem Siepen","year":"2019","journal-title":"Clin Res Cardiol."},{"issue":"1","key":"bib11-20260416","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jacc.2019.04.054","article-title":"Association of carpal tunnel syndrome with amyloidosis, heart failure, and adverse cardiovascular outcomes","volume":"74","author":"Fosb\u00f8l","year":"2019","journal-title":"J Am Coll Cardiol."},{"issue":"2","key":"bib12-20260416","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s40120-020-00210-7","article-title":"Transthyretin amyloidosis: update on the clinical spectrum, pathogenesis, and disease-modifying therapies","volume":"9","author":"Koike","year":"2020","journal-title":"Neurol Ther."},{"issue":"2","key":"bib13-20260416","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.humpath.2010.06.014","article-title":"Wild-type transthyretin significantly contributes to the formation of amyloid fibrils in familial amyloid polyneuropathy patients with amyloidogenic transthyretin Val30Met","volume":"42","author":"Tsuchiya-Suzuki","year":"2011","journal-title":"Hum Pathol."},{"issue":"6","key":"bib14-20260416","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/ehjcr\/ytaa329","article-title":"Wild-type transthyretin amyloid cardiomyopathy complicated by spinal canal stenosis, carpal tunnel syndrome, and rotator cuff tears: a case report","volume":"4","author":"Takashio","year":"2020","journal-title":"Eur Heart J Case Rep."},{"issue":"1","key":"bib15-20260416","doi-asserted-by":"crossref","first-page":"32","DOI":"10.3109\/13506121003619369","article-title":"Upper limb neuropathy such as carpal tunnel syndrome as an initial manifestation of ATTR Val30Met familial amyloid polyneuropathy","volume":"17","author":"Tojo","year":"2010","journal-title":"Amyloid."},{"issue":"19","key":"bib16-20260416","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.2106\/JBJS.20.02096","article-title":"Molecular and clinical elucidation of the mechanism of action of steroids in idiopathic carpal tunnel syndrome","volume":"103","author":"Yamanaka","year":"2021","journal-title":"J Bone Joint Surg Am."},{"key":"bib17-20260416","doi-asserted-by":"crossref","first-page":"156777","DOI":"10.1016\/j.cyto.2024.156777","article-title":"Inflammatory cytokines and carpal tunnel syndrome: a causal relationship revealed","volume":"184","author":"Yang","year":"2024","journal-title":"Cytokine."},{"issue":"6","key":"bib18-20260416","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1179\/1351000212Y.0000000027","article-title":"Total oxidative stress and antioxidant status in patients with carpal tunnel syndrome","volume":"17","author":"Demirkol","year":"2012","journal-title":"Redox Rep."},{"issue":"12","key":"bib19-20260416","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1002\/mus.880161215","article-title":"Sensitivity of three median-to-ulnar comparative tests in diagnosis of mild carpal tunnel syndrome","volume":"16","author":"Uncini","year":"1993","journal-title":"Muscle Nerve."},{"key":"bib20-20260416","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.bbrc.2022.12.027","article-title":"Pro-inflammatory cytokine secretion induced by amyloid transthyretin in human cardiac fibroblasts","volume":"642","author":"Magaud","year":"2023","journal-title":"Biochem Biophys Res Commun."},{"issue":"4","key":"bib21-20260416","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1167\/iovs.62.4.8","article-title":"Interleukin-1 and transforming growth factor beta: commonly opposing, but sometimes supporting, master regulators of the corneal wound healing response to injury","volume":"62","author":"Wilson","year":"2021","journal-title":"Invest Ophthalmol Vis Sci."},{"issue":"5","key":"bib22-20260416","doi-asserted-by":"crossref","first-page":"e35144","DOI":"10.1371\/journal.pone.0035144","article-title":"Macrophage-stimulated cardiac fibroblast production of IL-6 is essential for TGF \u03b2\/Smad activation and cardiac fibrosis induced by angiotensin II","volume":"7","author":"Ma","year":"2012","journal-title":"PLoS One."},{"issue":"7","key":"bib23-20260416","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1177\/1535370218761628","article-title":"Featured Article: TGF-\u03b21 dominates extracellular matrix rigidity for inducing differentiation of human cardiac fibroblasts to myofibroblasts","volume":"243","author":"Cho","year":"2018","journal-title":"Exp Biol Med (Maywood)."},{"issue":"20","key":"bib24-20260416","doi-asserted-by":"crossref","first-page":"e020358","DOI":"10.1161\/JAHA.120.020358","article-title":"Amyloid deposits and fibrosis on left ventricular endomyocardial biopsy correlate with extracellular volume in cardiac amyloidosis","volume":"10","author":"Pucci","year":"2021","journal-title":"J Am Heart Assoc."},{"issue":"9","key":"bib25-20260416","doi-asserted-by":"crossref","first-page":"852","DOI":"10.3390\/antiox9090852","article-title":"Oxidative stress: concept and some practical aspects","volume":"9","author":"Sies","year":"2020","journal-title":"Antioxidants (Basel)."},{"issue":"7","key":"bib26-20260416","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/s41580-022-00456-z","article-title":"Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology","volume":"23","author":"Sies","year":"2022","journal-title":"Nat Rev Mol Cell Biol."},{"issue":"9","key":"bib27-20260416","doi-asserted-by":"crossref","first-page":"4642","DOI":"10.3390\/ijms22094642","article-title":"The chemistry of reactive oxygen species (ROS) revisited: outlining their role in biological macromolecules (DNA, lipids and proteins) and induced pathologies","volume":"22","author":"Juan","year":"2021","journal-title":"Int J Mol Sci."},{"key":"bib28-20260416","doi-asserted-by":"crossref","first-page":"628157","DOI":"10.3389\/fcell.2021.628157","article-title":"Beneficial and detrimental effects of reactive oxygen species on lifespan: a comprehensive review of comparative and experimental studies","volume":"9","author":"Shields","year":"2021","journal-title":"Front Cell Dev Biol."},{"issue":"12","key":"bib29-20260416","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.3390\/antiox11122345","article-title":"Nrf2 and oxidative stress: a general overview of mechanisms and implications in human disease","volume":"11","author":"Ngo","year":"2022","journal-title":"Antioxidants (Basel)."},{"issue":"1","key":"bib30-20260416","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.abb.2010.03.019","article-title":"NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1), a multifunctional antioxidant enzyme and exceptionally versatile cytoprotector","volume":"501","author":"Dinkova-Kostova","year":"2010","journal-title":"Arch Biochem Biophys."},{"key":"bib31-20260416","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1146\/annurev-pharmtox-011112-140320","article-title":"Role of nrf2 in oxidative stress and toxicity","volume":"53","author":"Ma","year":"2013","journal-title":"Annu Rev Pharmacol Toxicol."},{"issue":"30","key":"bib32-20260416","doi-asserted-by":"crossref","first-page":"21606","DOI":"10.1074\/jbc.M113.487231","article-title":"Palmitoylation of superoxide dismutase 1 (SOD1) is increased for familial amyotrophic lateral sclerosis-linked SOD1 mutants","volume":"288","author":"Antinone","year":"2013","journal-title":"J Biol Chem."},{"issue":"2","key":"bib33-20260416","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s00418-013-1099-4","article-title":"Mammalian SOD2 is exclusively located in mitochondria and not present in peroxisomes","volume":"140","author":"Karnati","year":"2013","journal-title":"Histochem Cell Biol."},{"key":"bib34-20260416","doi-asserted-by":"crossref","first-page":"755","DOI":"10.3389\/fphys.2020.00755","article-title":"Manganese superoxide dismutase dysfunction and the pathogenesis of kidney disease","volume":"11","author":"Kitada","year":"2020","journal-title":"Front Physiol."},{"issue":"3","key":"bib35-20260416","doi-asserted-by":"crossref","first-page":"e0300046","DOI":"10.1371\/journal.pone.0300046","article-title":"Higher densities of T-lymphocytes in the subsynovial connective tissue of people with carpal tunnel syndrome","volume":"19","author":"Sandy-Hindmarch","year":"2024","journal-title":"PLoS One."},{"issue":"5","key":"bib36-20260416","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1007\/s00204-024-03696-4","article-title":"Several lines of antioxidant defense against oxidative stress: antioxidant enzymes, nanomaterials with multiple enzyme-mimicking activities, and low-molecular-weight antioxidants","volume":"98","author":"Jomova","year":"2024","journal-title":"Arch Toxicol."},{"issue":"4","key":"bib37-20260416","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.bbagen.2014.11.021","article-title":"Nrf2 regulates ROS production by mitochondria and NADPH oxidase","volume":"1850","author":"Kovac","year":"2015","journal-title":"Biochim Biophys Acta."},{"issue":"3","key":"bib38-20260416","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1046\/j.1365-2184.2003.00266.x","article-title":"The cell cycle: a review of regulation, deregulation and therapeutic targets in cancer","volume":"36","author":"Vermeulen","year":"2003","journal-title":"Cell Prolif."},{"key":"bib39-20260416","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1750-2187-3-15","article-title":"Gadd45 in stress signaling","volume":"3","author":"Liebermann","year":"2008","journal-title":"J Mol Signal."},{"issue":"7589","key":"bib40-20260416","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/nature16932","article-title":"Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan","volume":"530","author":"Baker","year":"2016","journal-title":"Nature."},{"issue":"7","key":"bib41-20260416","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/s43587-023-00446-6","article-title":"Spatial mapping of cellular senescence: emerging challenges and opportunities","volume":"3","author":"Gurkar","year":"2023","journal-title":"Nat Aging."},{"key":"bib42-20260416","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-3-030-94804-7_1","article-title":"GADD45 in stress signaling, cell cycle control, and apoptosis","volume":"1360","author":"Humayun","year":"2022","journal-title":"Adv Exp Med Biol."},{"issue":"1","key":"bib43-20260416","doi-asserted-by":"crossref","first-page":"H149","DOI":"10.1152\/ajpheart.00073.2021","article-title":"Transthyretin amyloid fibrils alter primary fibroblast structure, function, and inflammatory gene expression","volume":"321","author":"Dittloff","year":"2021","journal-title":"Am J Physiol Heart Circ Physiol."},{"key":"bib44-20260416","doi-asserted-by":"crossref","first-page":"14532","DOI":"10.1038\/ncomms14532","article-title":"Cellular senescence mediates fibrotic pulmonary disease","volume":"8","author":"Schafer","year":"2017","journal-title":"Nat Commun."},{"issue":"2","key":"bib45-20260416","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1046\/j.1523-1747.2002.01641.x","article-title":"Transforming growth factor-beta signaling through the Smad pathway: role in extracellular matrix gene expression and regulation","volume":"118","author":"Verrecchia","year":"2002","journal-title":"J Invest Dermatol."},{"issue":"3","key":"bib46-20260416","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.jhsa.2004.02.003","article-title":"Patient-reported outcome after carpal tunnel release for advanced disease: a prospective and longitudinal assessment in patients older than age 70","volume":"29","author":"Leit","year":"2004","journal-title":"J Hand Surg Am."},{"issue":"1","key":"bib47-20260416","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s40119-020-00205-3","article-title":"Estimating the gender distribution of patients with wild-type transthyretin amyloid cardiomyopathy: a systematic review and meta-analysis","volume":"10","author":"Kroi","year":"2021","journal-title":"Cardiol Ther."},{"issue":"4","key":"bib48-20260416","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/s10571-008-9339-1","article-title":"17beta-estradiol induces transthyretin expression in murine choroid plexus via an oestrogen receptor dependent pathway","volume":"29","author":"Quintela","year":"2009","journal-title":"Cell Mol Neurobiol."},{"issue":"2","key":"bib49-20260416","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.gene.2013.06.078","article-title":"A distal estrogen responsive element upstream the cap site of human transthyretin gene is an enhancer-like element upon ER\u03b1 and\/or ER\u03b2 transactivation","volume":"527","author":"Martinho","year":"2013","journal-title":"Gene."},{"issue":"16","key":"bib50-20260416","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1161\/CIRCULATIONAHA.115.016567","article-title":"Prognostic value of late gadolinium enhancement cardiovascular magnetic resonance in cardiac amyloidosis","volume":"132","author":"Fontana","year":"2015","journal-title":"Circulation."}],"container-title":["Journal of Bone and Joint Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.2106\/JBJS.25.00807","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T13:21:29Z","timestamp":1787750489000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.2106\/JBJS.25.00807"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,12]]},"references-count":50,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.2106\/jbjs.25.00807","relation":{},"ISSN":["0021-9355","1535-1386"],"issn-type":[{"value":"0021-9355","type":"print"},{"value":"1535-1386","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,12]]}}}