{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T01:50:00Z","timestamp":1791510600442,"version":"4.3.4"},"reference-count":89,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"15","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,8,5]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      <jats:list list-type=\"plain\">\n                        <jats:list-item>\n                          <jats:p>\u27a2 The relationship between the gastrointestinal tract and joint diseases has garnered increased attention over recent decades, leading to the introduction of the gut-joint axis concept.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\u27a2 Infections at sites such as joints and the spine may originate endogenously from the gut microbiome.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\u27a2 The idea of microbial translocation through a compromised epithelial barrier, resulting in the circulation of pathogens or their byproducts, and the idea of immune cell-mediated transport of pathogens to various sites are gaining further attention.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\u27a2 By understanding the interaction between the immune system and gut microbiota, potential therapeutic strategies, such as the use of organoids, can be developed to restore the gut barrier integrity, to replenish gut microbiota, and to provide biodiversity.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\u27a2 To better understand the mechanisms linking gut health and joint diseases, future basic-science research and well-designed clinical trials, exploiting advanced next-generation sequencing techniques, are needed.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.2106\/jbjs.25.01100","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T21:02:26Z","timestamp":1781730146000},"page":"1164-1172","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Heading Toward a Different Future: The Microbiome, Dysbiosis, Microbial Translocation, and Beyond"],"prefix":"10.2106","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6849-3679","authenticated-orcid":false,"given":"Mincong","family":"He","sequence":"first","affiliation":[{"name":"Guangdong Research Institute for Orthopedics and Traumatology of Chinese Medicine, Third Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, People\u2019s Republic of China"},{"name":"International Joint Center, Acibadem Mehmet Ali Ayd\u0131nlar University, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0929-3586","authenticated-orcid":false,"given":"Augusto","family":"Ferrini","sequence":"additional","affiliation":[{"name":"International Joint Center, Acibadem Mehmet Ali Ayd\u0131nlar University, Istanbul, Turkey"},{"name":"Operative Research Unit of Orthopaedic and Trauma Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0933-6806","authenticated-orcid":false,"given":"Emanuele","family":"Chisari","sequence":"additional","affiliation":[{"name":"Parvizi Surgical Innovation, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3221-9368","authenticated-orcid":false,"given":"Frank","family":"Kolhoff","sequence":"additional","affiliation":[{"name":"International Joint Center, Acibadem Mehmet Ali Ayd\u0131nlar University, Istanbul, Turkey"},{"name":"Department of Orthopedics, Spaarne Gasthuis, Hoofddorp, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2611-2767","authenticated-orcid":false,"given":"Priya","family":"Sehgal","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6985-5870","authenticated-orcid":false,"given":"Javad","family":"Parvizi","sequence":"additional","affiliation":[{"name":"International Joint Center, Acibadem Mehmet Ali 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