{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:19:17Z","timestamp":1787753957167,"version":"build-2784847793"},"reference-count":88,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,6,3]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>Knee pain resulting from acute trauma and overuse injury is common among athletes and represents a major cause of reduced performance, time loss from sport, and long-term sequelae including osteoarthritis. Injectable therapies are frequently used as a nonoperative treatment modality to alleviate symptoms and facilitate early return to sport.<\/jats:p>\n                    <jats:p>This review evaluates the current evidence on commonly used knee injectables in the younger athletic population with pre-arthritic knee pain, including corticosteroids, hyaluronic acid, platelet-rich plasma (PRP), and other biologics. Relevant literature was identified without restriction on study design and with a focus on athlete-specific outcomes and clinical applicability.<\/jats:p>\n                    <jats:p>Overall, the available evidence on knee injectables for athletes remains limited, heterogeneous, and largely extrapolated from older, nonathletic cohorts. In the absence of available athlete-specific guidelines, most injectables carry weak and\/or conditional recommendations, highlighting the need for individualized treatment and shared decision-making. High-quality, sport-specific clinical trials are required to establish clear guidelines and optimize outcomes in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2106\/jbjs.26.00267","type":"journal-article","created":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T18:03:55Z","timestamp":1776362635000},"page":"835-841","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Knee Injectables in Young Athletes"],"prefix":"10.2106","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8442-9768","authenticated-orcid":false,"given":"Ashraf","family":"Hantouly","sequence":"first","affiliation":[{"name":"Division of Orthopaedic Surgery, McMaster University, Hamilton, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8926-7139","authenticated-orcid":false,"given":"Asheesh","family":"Bedi","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, University of Michigan, Ann Arbor, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8237-8095","authenticated-orcid":false,"given":"Moin","family":"Khan","sequence":"additional","affiliation":[{"name":"Division of Orthopaedic Surgery, McMaster University, Hamilton, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,4,16]]},"reference":[{"issue":"3","key":"bib1-20260603","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1002\/jor.25257","article-title":"Mechanism of non-contact ACL injury: OREF Clinical Research Award 2021","volume":"40","author":"Boden","year":"2022","journal-title":"J Orthop Res."},{"issue":"5","key":"bib2-20260603","doi-asserted-by":"crossref","first-page":"472","DOI":"10.4085\/1062-6050-407-16","article-title":"Anterior Cruciate Ligament Injury Risk in Sport: A Systematic Review and Meta-Analysis of Injury Incidence by Sex and Sport Classification","volume":"54","author":"Montalvo","year":"2019","journal-title":"J Athl Train."},{"issue":"7","key":"bib3-20260603","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1007\/s00167-009-0813-1","article-title":"Prevention of non-contact anterior cruciate ligament injuries in soccer players. Part 1: Mechanisms of injury and underlying risk factors","volume":"17","author":"Alentorn-Geli","year":"2009","journal-title":"Knee Surg Sports Traumatol Arthrosc."},{"issue":"8","key":"bib4-20260603","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1177\/0363546517730072","article-title":"High Rates of Osteoarthritis Develop After Anterior Cruciate Ligament Surgery: An Analysis of 4108 Patients","volume":"46","author":"Cinque","year":"2018","journal-title":"Am J Sports Med."},{"issue":"5","key":"bib5-20260603","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1177\/0363546515626539","article-title":"Changes in Knee Osteoarthritis, Symptoms, and Function After Anterior Cruciate Ligament Reconstruction: A 20-Year Prospective Follow-up Study","volume":"44","author":"Risberg","year":"2016","journal-title":"Am J Sports Med."},{"issue":"5","key":"bib6-20260603","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1177\/0363546517751683","article-title":"Twenty-Year Follow-up Study Comparing Operative Versus Nonoperative Treatment of Anterior Cruciate Ligament Ruptures in High-Level Athletes","volume":"46","author":"van Yperen","year":"2018","journal-title":"Am J Sports Med."},{"issue":"23","key":"bib7-20260603","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1136\/bjsports-2018-100022","article-title":"Knee osteoarthritis risk is increased 4-6 fold after knee injury - a systematic review and meta-analysis","volume":"53","author":"Poulsen","year":"2019","journal-title":"Br J Sports Med."},{"issue":"12","key":"bib8-20260603","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1136\/bjsports-2019-100959","article-title":"Risk of knee osteoarthritis after different types of knee injuries in young adults: a population-based cohort study","volume":"54","author":"Snoeker","year":"2020","journal-title":"Br J Sports Med."},{"issue":"1_suppl","key":"bib9-20260603","doi-asserted-by":"crossref","first-page":"873S","DOI":"10.1177\/19476035211018857","article-title":"Differences in the Demographics and Preferred Management of Knee Cartilage Injuries in Soccer Players Across FIFA Centers of Excellence","volume":"13","author":"Marom","year":"2021","journal-title":"Cartilage."},{"issue":"11","key":"bib10-20260603","doi-asserted-by":"crossref","first-page":"2827","DOI":"10.1007\/s00264-024-06301-6","article-title":"Injection therapy in professional footballers","volume":"48","author":"Jader","year":"2024","journal-title":"Int Orthop."},{"issue":"1","key":"bib11-20260603","first-page":"00185","article-title":"Utilization of Orthobiologics by Sports Medicine Physicians: A Survey-based Study","volume":"5","author":"Noback","year":"2021","journal-title":"J Am Acad Orthop Surg Glob Res Rev."},{"issue":"10","key":"bib12-20260603","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1007\/s00264-022-05566-z","article-title":"Would you have an injection without knowing its formula? 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