{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T17:17:50Z","timestamp":1788369470167,"version":"build-2803163510"},"reference-count":104,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"17","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,9,2]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      <jats:list list-type=\"plain\">\n                        <jats:list-item>\n                          <jats:p>\u27a2 Peptides lack a rigid tertiary structure, allowing them to adopt a variety of conformations, and can be engineered for specific targets. This article examines the design principles underlying orthopaedic peptide applications, from preclinical candidates to clinically validated drugs.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\u27a2 The use of peptides in orthopaedics began with naturally occurring agents, such as bone morphogenetic proteins, and has evolved toward rationally engineered synthetics.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\u27a2 Teriparatide, a synthetic parathyroid hormone-derived peptide, is used for bone regeneration; PLG0206, a fully engineered antimicrobial peptide, has demonstrated activity against biofilm-forming and multidrug-resistant organisms that conventional antibiotics cannot eradicate, and is advancing through Phase-II and III clinical evaluations.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\u27a2 Peptide engineering has produced candidates with potential for cartilage-penetrating, sustained local drug delivery, although no peptide-based disease-modifying osteoarthritis drug has yet achieved clinical validation.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\u27a2 Artificial intelligence-driven peptide design is accelerating discovery, but the translation of computationally designed sequences to clinical efficacy remains an active challenge.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.2106\/jbjs.26.00785","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T18:00:45Z","timestamp":1784656845000},"page":"1362-1371","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Peptide Therapeutics in Orthopaedics"],"prefix":"10.2106","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4511-1308","authenticated-orcid":false,"given":"Kenneth L.","family":"Urish","sequence":"first","affiliation":[{"name":"Arthritis and Arthroplasty Design Lab, Bethel Musculoskeletal Research Center, Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania"},{"name":"The Bone and Joint Center, Magee-Womens Hospital of the University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania"},{"name":"Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania"},{"name":"Clinical and Translational Science 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