{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:51:08Z","timestamp":1791312668805,"version":"4.3.1"},"reference-count":54,"publisher":"Ovid Technologies (Wolters Kluwer Health)","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:p>\n                    <jats:list list-type=\"plain\">\n                      <jats:list-item>\n                        <jats:p>\u27a2 Ankle cartilage damage ranges from osteochondral lesions of the talus to end-stage osteoarthritis. End-stage ankle osteoarthritis has been associated with a health burden comparable with that of major chronic diseases such as congestive heart failure and kidney disease, while predominantly affecting young and active patients.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>\u27a2 Ankle osteoarthritis often has a posttraumatic nature, making it possible to study the long-term results of traumatic articular injuries and identify potential targets for early therapeutic interventions.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>\u27a2 The scientific literature has been predominantly focused on outcomes after surgical treatment of osteochondral lesions of the talus or osteoarthritis. However, evidence on nonoperative treatment has been limited and methodologically weak, with evidence for early interventions (e.g., lifestyle or biologicals) even more scarce.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>\u27a2 The greatest opportunity to improve long-term outcomes in ankle cartilage damage may be early recognition and early initiation of treatment.<\/jats:p>\n                      <\/jats:list-item>\n                    <\/jats:list>\n                  <\/jats:p>","DOI":"10.2106\/jbjs.26.00827","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:01:30Z","timestamp":1791309690000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["From Sprain to End-Stage Osteoarthritis: Why Earlier Intervention in Ankle Cartilage Damage Deserves More Attention"],"prefix":"10.2106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8345-1648","authenticated-orcid":false,"given":"Julian J.","family":"Hollander","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery and Sports Medicine, Amsterdam UMC \u2013 Location AMC, University of Amsterdam, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6849-1008","authenticated-orcid":false,"given":"Jari","family":"Dahmen","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery and Sports Medicine, Amsterdam UMC \u2013 Location AMC, University of Amsterdam, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher D.","family":"Murawski","sequence":"additional","affiliation":[{"name":"Division of Foot and Ankle, OrthoCarolina, Charlotte, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arianna 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Woo","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Yonsei University College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2223-3211","authenticated-orcid":false,"given":"Daniel","family":"Guss","sequence":"additional","affiliation":[{"name":"Foot & Ankle Research and Innovation Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts"},{"name":"Foot & Ankle Service, Department of Orthopaedic Surgery, Massachusetts General Hospital, Boston, Massachusetts"},{"name":"Newton-Wellesley Hospital, Wellesley, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6717-0122","authenticated-orcid":false,"given":"Eric I.","family":"Ferkel","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Southern California Orthopedic Institute, Van Nuys, 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