{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:35:23Z","timestamp":1787754923797,"version":"build-2784847793"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JBJS Case Connector"],"published-print":{"date-parts":[[2016,8,24]]},"abstract":"<jats:sec>\n                    <jats:title>Case:<\/jats:title>\n                    <jats:p>Bevacizumab is a vascular endothelial growth factor (VEGF) inhibitor that is involved in the inhibition of vasculogenesis and angiogenesis. We report the case of a patient who developed a severe skin ulcer at the site of the surgical incision 5 years after clavicular fracture fixation with a titanium plate. This ulcer represents an adverse event of bevacizumab therapy for sigmoid colon cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Bevacizumab therapy is widely used, particularly for the treatment of metastatic colon cancer and other solid tumors, although it is associated with several adverse events, including delayed wound-healing and skin ulcers. However, to our knowledge, orthopaedic-related adverse events have not previously been reported.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2106\/jbjs.cc.15.00281","type":"journal-article","created":{"date-parts":[[2016,8,24]],"date-time":"2016-08-24T22:58:44Z","timestamp":1472079524000},"page":"e70","source":"Crossref","is-referenced-by-count":2,"title":["Large Skin Ulcer Due to a Subcutaneous Orthopaedic Implant After Bevacizumab Therapy"],"prefix":"10.2106","volume":"6","author":[{"given":"Yoshiyuki","family":"Suehara","sequence":"first","affiliation":[{"name":"Departments of Orthopedic Surgery (Y.S., H.O., D.K., K.A., Y.T., and K.K.), Medical Oncology (S.K.), and Human Pathology (K.A. and T.S.), Juntendo University School of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideomi","family":"Osawa","sequence":"additional","affiliation":[{"name":"Departments of Orthopedic Surgery (Y.S., H.O., D.K., K.A., Y.T., and K.K.), Medical Oncology (S.K.), and Human Pathology (K.A. and T.S.), Juntendo University School of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Kubota","sequence":"additional","affiliation":[{"name":"Departments of Orthopedic Surgery (Y.S., H.O., D.K., K.A., Y.T., and K.K.), Medical Oncology (S.K.), and Human Pathology (K.A. and T.S.), Juntendo University School of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunsuke","family":"Kato","sequence":"additional","affiliation":[{"name":"Departments of Orthopedic Surgery (Y.S., H.O., D.K., K.A., Y.T., and K.K.), Medical Oncology (S.K.), and Human Pathology (K.A. and T.S.), Juntendo University School of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisuke","family":"Akaike","sequence":"additional","affiliation":[{"name":"Departments of Orthopedic Surgery (Y.S., H.O., D.K., K.A., Y.T., and K.K.), Medical Oncology (S.K.), and Human Pathology (K.A. and T.S.), Juntendo University School of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Tanabe","sequence":"additional","affiliation":[{"name":"Departments of Orthopedic Surgery (Y.S., H.O., D.K., K.A., Y.T., and K.K.), Medical Oncology (S.K.), and Human Pathology (K.A. and T.S.), Juntendo University School of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Saito","sequence":"additional","affiliation":[{"name":"Departments of Orthopedic Surgery (Y.S., H.O., D.K., K.A., Y.T., and K.K.), Medical Oncology (S.K.), and Human Pathology (K.A. and T.S.), Juntendo University School of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Kaneko","sequence":"additional","affiliation":[{"name":"Departments of Orthopedic Surgery (Y.S., H.O., D.K., K.A., Y.T., and K.K.), Medical Oncology (S.K.), and Human Pathology (K.A. and T.S.), Juntendo University School of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"issue":"6","key":"bib1-20230712","doi-asserted-by":"crossref","first-page":"507","DOI":"10.2165\/11597600-000000000-00000","article-title":"Novel adverse events of bevacizumab in the US FDA adverse event reporting system database: a disproportionality analysis","volume":"35","author":"Shamloo","year":"2012","journal-title":"Drug Saf."},{"key":"bib2-20230712","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/1756-9966-29-95","article-title":"Hypertension and hand-foot skin reactions related to VEGFR2 genotype and improved clinical outcome following bevacizumab and sorafenib","volume":"29","author":"Jain","year":"2010","journal-title":"J Exp Clin Cancer Res."},{"issue":"10","key":"bib3-20230712","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/j.ad.2014.02.010","article-title":"Antiangiogenic agents and the skin: cutaneous adverse effects of sorafenib, sunitinib, and bevacizumab","volume":"105","author":"Ara","year":"2014","journal-title":"Actas Dermosifiliogr."},{"issue":"4","key":"bib4-20230712","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/S1470-2045(09)70341-9","article-title":"Vascular endothelial growth factor targeted therapy in the perioperative setting: implications for patient care","volume":"11","author":"Bose","year":"2010","journal-title":"Lancet Oncol."},{"issue":"10","key":"bib5-20230712","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1097\/CAD.0b013e328349c7bb","article-title":"Wound healing and catheter thrombosis after implantable venous access device placement in 266 breast cancers treated with bevacizumab 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paclitaxel for skin metastases from breast cancer: report of a case","volume":"45","author":"Kijima","year":"2015","journal-title":"Surg Today."},{"issue":"13","key":"bib9-20230712","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.2106\/JBJS.M.00607","article-title":"Rate of and risk factors for reoperations after open reduction and internal fixation of midshaft clavicle fractures: a population-based study in Ontario, Canada","volume":"96","author":"Leroux","year":"2014","journal-title":"J Bone Joint Surg Am."},{"issue":"4","key":"bib10-20230712","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/s00402-010-1196-y","article-title":"Treatment of distal clavicle fracture: a systematic review of treatment modalities in 425 fractures","volume":"131","author":"Oh","year":"2011","journal-title":"Arch Orthop Trauma Surg."},{"issue":"5","key":"bib11-20230712","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1007\/s00402-011-1456-5","article-title":"Systematic review of the complications of plate fixation of clavicle fractures","volume":"132","author":"Wijdicks","year":"2012","journal-title":"Arch Orthop Trauma Surg."}],"container-title":["JBJS Case Connector"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/01709767-201606030-00019","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T13:34:51Z","timestamp":1787751291000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/01709767-201606030-00019"}},"subtitle":["A Case Report"],"short-title":[],"issued":{"date-parts":[[2016,8,24]]},"references-count":11,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.2106\/jbjs.cc.15.00281","relation":{},"ISSN":["2160-3251"],"issn-type":[{"value":"2160-3251","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,24]]}}}