{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:19:34Z","timestamp":1790738374408,"version":"4.1.0"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JBJS Case Connector"],"published-print":{"date-parts":[[2018,3]]},"abstract":"\n Case:<\/jats:title>\n \n A patient presenting with an infected diabetic foot ulcer and\n Staphylococcus aureus<\/jats:italic>\n chronic osteomyelitis was studied to validate the clinical importance of bacterial colonization of osteocytic-canalicular networks, as we recently reported in a mouse model. We utilized transmission electron microscopy to describe the deformation of\n S. aureus,<\/jats:italic>\n from round cocci to rod-shaped bacteria, in the submicron osteocytic-canalicular networks of amputated bone tissue.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n \n To our knowledge, this is the first evidence of\n S. aureus<\/jats:italic>\n deformation and invasion of the osteocytic-canalicular system in human bone, which supports a new mechanism of persistence in the pathogenesis of chronic osteomyelitis.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.2106\/jbjs.cc.17.00154","type":"journal-article","created":{"date-parts":[[2018,2,14]],"date-time":"2018-02-14T12:16:17Z","timestamp":1518610577000},"page":"e8-e8","source":"Crossref","is-referenced-by-count":106,"title":["Chronic Osteomyelitis with Staphylococcus aureus Deformation in Submicron Canaliculi of Osteocytes"],"prefix":"10.2106","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0176-1111","authenticated-orcid":false,"given":"Karen L.","family":"de Mesy Bentley","sequence":"first","affiliation":[{"name":"Center for Musculoskeletal Research (K.L.d.M.B., A.M., E.M.S., and I.O.) and Departments of Pathology and Laboratory Medicine (K.L.d.M.B. and E.M.S.) and Orthopaedics (K.L.d.M.B., A.M., E.M.S., and I.O.), University of Rochester School of Medicine and Dentistry, Rochester, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashlee","family":"MacDonald","sequence":"additional","affiliation":[{"name":"Center for Musculoskeletal Research (K.L.d.M.B., A.M., E.M.S., and I.O.) and Departments of Pathology and Laboratory Medicine (K.L.d.M.B. and E.M.S.) and Orthopaedics (K.L.d.M.B., A.M., E.M.S., and I.O.), University of Rochester School of Medicine and Dentistry, Rochester, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward M.","family":"Schwarz","sequence":"additional","affiliation":[{"name":"Center for Musculoskeletal Research (K.L.d.M.B., A.M., E.M.S., and I.O.) and Departments of Pathology and Laboratory Medicine (K.L.d.M.B. and E.M.S.) and Orthopaedics (K.L.d.M.B., A.M., E.M.S., and I.O.), University of Rochester School of Medicine and Dentistry, Rochester, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2648-5849","authenticated-orcid":false,"given":"Irvin","family":"Oh","sequence":"additional","affiliation":[{"name":"Center for Musculoskeletal Research (K.L.d.M.B., A.M., E.M.S., and I.O.) and Departments of Pathology and Laboratory Medicine (K.L.d.M.B. and E.M.S.) and Orthopaedics (K.L.d.M.B., A.M., E.M.S., and I.O.), University of Rochester School of Medicine and Dentistry, Rochester, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2018,2,14]]},"reference":[{"issue":"3","key":"bib1-20230713","doi-asserted-by":"crossref","first-page":"651","DOI":"10.2337\/dc13-2176","article-title":"Burden of diabetic foot ulcers for Medicare and private insurers","volume":"37","author":"Rice","year":"2014","journal-title":"Diabetes Care."},{"issue":"Suppl 2","key":"bib2-20230713","doi-asserted-by":"crossref","first-page":"S104","DOI":"10.1086\/383271","article-title":"Medical treatment of diabetic foot infections","volume":"39","author":"Lipsky","year":"2004","journal-title":"Clin Infect Dis."},{"issue":"6","key":"bib3-20230713","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1006\/mpat.1995.0075","article-title":"Internalization of Staphylococcus aureus by cultured osteoblasts","volume":"19","author":"Hudson","year":"1995","journal-title":"Microb Pathog."},{"issue":"6","key":"bib4-20230713","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1302\/0301-620X.85B6.13509","article-title":"Intracellular Staphylococcus aureus. A mechanism for the indolence of osteomyelitis","volume":"85","author":"Ellington","year":"2003","journal-title":"J Bone Joint Surg Br."},{"issue":"1","key":"bib5-20230713","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S8756-3282(99)00239-2","article-title":"In vivo internalization of Staphylococcus aureus by embryonic chick osteoblasts","volume":"26","author":"Reilly","year":"2000","journal-title":"Bone."},{"issue":"6","key":"bib6-20230713","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.2106\/00004623-200506000-00022","article-title":"Internalization of bacteria by osteoblasts in a patient with recurrent, long-term osteomyelitis. A case report","volume":"87","author":"Bosse","year":"2005","journal-title":"J Bone Joint Surg Am."},{"issue":"5","key":"bib7-20230713","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1002\/jbmr.3055","article-title":"Evidence of Staphylococcus aureus deformation, proliferation, and migration in canaliculi of live cortical bone in murine models of osteomyelitis","volume":"32","author":"de Mesy Bentley","year":"2017","journal-title":"J Bone Miner Res."},{"issue":"6","key":"bib8-20230713","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1093\/jac\/dkp107","article-title":"One hundred and twelve infected arthroplasties treated with \u2018DAIR\u2019 (debridement, antibiotics and implant retention): antibiotic duration and outcome","volume":"63","author":"Byren","year":"2009","journal-title":"J Antimicrob Chemother."},{"issue":"5","key":"bib9-20230713","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1056\/NEJMc1111493","article-title":"Staphylococcus aureus reactivation osteomyelitis after 75 years","volume":"366","author":"Libraty","year":"2012","journal-title":"N Engl J Med."},{"issue":"8","key":"bib10-20230713","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1111\/j.1532-5415.1999.tb01305.x","article-title":"Reactivation of osteomyelitis caused by Staphylococcus aureus after 50 years","volume":"47","author":"Donati","year":"1999","journal-title":"J Am Geriatr Soc."},{"issue":"5","key":"bib11-20230713","doi-asserted-by":"crossref","first-page":"403","DOI":"10.3928\/01477447-20070501-12","article-title":"Recurrence of chronic osteomyelitis in a regenerated fibula after 65 years","volume":"30","author":"Al-Maiyah","year":"2007","journal-title":"Orthopedics."}],"container-title":["JBJS Case Connector"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/01709767-201803000-00010","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T13:42:22Z","timestamp":1787751742000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/01709767-201803000-00010"}},"subtitle":["A Case Report"],"short-title":[],"issued":{"date-parts":[[2018,2,14]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.2106\/jbjs.cc.17.00154","relation":{},"ISSN":["2160-3251"],"issn-type":[{"value":"2160-3251","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,14]]}}}