{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T06:39:16Z","timestamp":1789713556966,"version":"4.0.1"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JBJS Case Connector"],"abstract":"<jats:sec>\n                    <jats:title>Case:<\/jats:title>\n                    <jats:p>\n                      A 22-year-old man sustained a laceration that measured 180 cm\n                      <jats:sup>2<\/jats:sup>\n                      , after debridement, over the anterolateral aspect of the right leg following a road traffic accident. The wound was treated with MyDerm (Universiti Kebangsaan Malaysia), a cell-based, bilayered, bioengineered dermal substitute that contains no animal-derived components and is fully autologous. For its construction, only a small area of skin was harvested from the left groin, which was closed primarily with absorbable sutures.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>MyDerm is an alternative option for the treatment of a massive skin defect in patients who desire removal of only a negligible amount of skin from the donor site and when use of an autograft is insufficient.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2106\/jbjs.cc.17.00250","type":"journal-article","created":{"date-parts":[[2018,6,13]],"date-time":"2018-06-13T13:15:52Z","timestamp":1528895752000},"page":"e38-e38","source":"Crossref","is-referenced-by-count":16,"title":["Massive Traumatic Skin Defect Successfully Treated with Autologous, Bilayered, Tissue-Engineered MyDerm Skin Substitute"],"prefix":"10.2106","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5408-3943","authenticated-orcid":false,"given":"Nor Hazla","family":"Mohamed Haflah","sequence":"first","affiliation":[{"name":"Department of Orthopaedics and Traumatology (N.H.M.H., A.S.N., O.H., and K.A.A.R.), Tissue Engineering Centre (M.H.N.), and Department of Physiology (M.H.M.Y. and R.I.), Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Hwei","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Traumatology (N.H.M.H., A.S.N., O.H., and K.A.A.R.), Tissue Engineering Centre (M.H.N.), and Department of Physiology (M.H.M.Y. and R.I.), Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohd Heikal","family":"Mohd Yunus","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Traumatology (N.H.M.H., A.S.N., O.H., and K.A.A.R.), Tissue Engineering Centre (M.H.N.), and Department of Physiology (M.H.M.Y. and R.I.), Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amaramalar Selvi","family":"Naicker","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Traumatology (N.H.M.H., A.S.N., O.H., and K.A.A.R.), Tissue Engineering Centre (M.H.N.), and Department of Physiology (M.H.M.Y. and R.I.), Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ohnmar","family":"Htwe","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Traumatology (N.H.M.H., A.S.N., O.H., and K.A.A.R.), Tissue Engineering Centre (M.H.N.), and Department of Physiology (M.H.M.Y. and R.I.), Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamarul Arifin","family":"Abdul Razak","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Traumatology (N.H.M.H., A.S.N., O.H., and K.A.A.R.), Tissue Engineering Centre (M.H.N.), and Department of Physiology (M.H.M.Y. and R.I.), Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruszymah","family":"Idrus","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Traumatology (N.H.M.H., A.S.N., O.H., and K.A.A.R.), Tissue Engineering Centre (M.H.N.), and Department of Physiology (M.H.M.Y. and R.I.), Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2018,6]]},"reference":[{"key":"bib1-20230712","first-page":"8","article-title":"Skin function and wound healing physiology","volume":"1","author":"Timmons","year":"2006","journal-title":"Wound Essentials."},{"issue":"3","key":"bib2-20230712","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.burns.2006.08.022","article-title":"Reconstruction of living bilayer human skin equivalent utilizing human fibrin as a scaffold","volume":"33","author":"Mazlyzam","year":"2007","journal-title":"Burns."},{"key":"bib3-20230712","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1745-6215-14-8","article-title":"Cellular versus acellular matrix devices in treatment of diabetic foot ulcers: study protocol for a comparative efficacy randomized controlled trial","volume":"14","author":"Lev-Tov","year":"2013","journal-title":"Trials."},{"key":"bib4-20230712","article-title":"The search for an ideal temporary skin substitute: AWBAT","volume":"9","author":"Woodroof","year":"2009","journal-title":"Eplasty."},{"issue":"3","key":"bib5-20230712","doi-asserted-by":"crossref","first-page":"547","DOI":"10.3390\/jfb6030547","article-title":"Advances in skin substitutes-potential of tissue engineered skin for facilitating anti-fibrotic healing","volume":"6","author":"Varkey","year":"2015","journal-title":"J Funct Biomater."},{"issue":"10","key":"bib6-20230712","first-page":"44","article-title":"Skin substitutes: an overview of the key players in wound management","volume":"7","author":"Nathoo","year":"2014","journal-title":"J Clin Aesthet Dermatol."},{"issue":"4","key":"bib7-20230712","doi-asserted-by":"crossref","first-page":"e789","DOI":"10.3390\/ijms18040789","article-title":"Advances in skin regeneration using tissue engineering","volume":"18","author":"Vig","year":"2017","journal-title":"Int J Mol Sci."},{"issue":"4","key":"bib8-20230712","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1097\/01.ASW.0000445199.26874.9d","article-title":"Full-thickness skin wound healing using autologous keratinocytes and dermal fibroblasts with fibrin: bilayered versus single-layered substitute","volume":"27","author":"Idrus","year":"2014","journal-title":"Adv Skin Wound Care."},{"issue":"1","key":"bib9-20230712","doi-asserted-by":"crossref","first-page":"e284","DOI":"10.1097\/GOX.0000000000000219","article-title":"Dermal matrices and bioengineered skin substitutes: a critical review of current options","volume":"3","author":"Debels","year":"2015","journal-title":"Plast Reconstr Surg Glob Open."},{"issue":"8","key":"bib10-20230712","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.arcmed.2008.09.001","article-title":"Human serum is an advantageous supplement for human dermal fibroblast expansion: clinical implications for tissue engineering of skin","volume":"39","author":"Mazlyzam","year":"2008","journal-title":"Arch Med Res."}],"container-title":["JBJS Case Connector"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/01709767-201806000-00017","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T13:43:23Z","timestamp":1787751803000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/01709767-201806000-00017"}},"subtitle":["A Case Report"],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":10,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.2106\/jbjs.cc.17.00250","relation":{},"ISSN":["2160-3251"],"issn-type":[{"value":"2160-3251","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6]]}}}