{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:40:27Z","timestamp":1787755227720,"version":"build-2784847793"},"reference-count":6,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JBJS Case Connector"],"abstract":"<jats:sec>\n                    <jats:title>Case:<\/jats:title>\n                    <jats:p>A 38-year-old man presented with multifocal, partially confluent osteolytic lesions in the proximal dia-meta-epiphyseal region of the proximal aspect of the left tibia, which had been found incidentally when a radiograph was made after a rotational knee injury. When the results of a percutaneous core needle biopsy proved inconclusive, an open biopsy was performed. Osteofibrous dysplasia (OFD) with scattered groups of plump cells with a rhabdoid phenotype, shown to express both vimentin and pan-cytokeratin, was found. Because the lesion was an incidental finding, we decided to proceed with observation. Three months after the open biopsy, imaging showed marked regression of the lesion; there was nearly complete normalization 5 years later.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>To our knowledge, there has been only 1 prior reported case with these pathologic features, and there have been no reports of complete spontaneous regression in an adult patient with OFD. Treatment recommendations for OFD and for OFD-like adamantinoma range from observation to aggressive resection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2106\/jbjs.cc.17.00294","type":"journal-article","created":{"date-parts":[[2018,7,11]],"date-time":"2018-07-11T11:49:23Z","timestamp":1531309763000},"page":"e51-e51","source":"Crossref","is-referenced-by-count":3,"title":["Osteofibrous Dysplasia with Rhabdoid Elements in a 38-Year-Old Man with Spontaneous Regression Over Five Years"],"prefix":"10.2106","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7553-7123","authenticated-orcid":false,"given":"G. Ulrich","family":"Exner","sequence":"first","affiliation":[{"name":"Orthopaedie Zentrum Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur R.","family":"von Hochstetter","sequence":"additional","affiliation":[{"name":"Pathologie Institut Enge, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian W.A.","family":"Pfirrmann","sequence":"additional","affiliation":[{"name":"Department of Radiology, Universitaetsklinik Balgrist, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2018,9]]},"reference":[{"issue":"3","key":"bib1-20230811","doi-asserted-by":"crossref","first-page":"367","DOI":"10.2106\/00004623-198163030-00007","article-title":"Osteofibrous dysplasia of the tibia and fibula","volume":"63","author":"Campanacci","year":"1981","journal-title":"J Bone Joint Surg Am."},{"issue":"6","key":"bib3-20230811","doi-asserted-by":"crossref","first-page":"358","DOI":"10.5435\/00124635-201006000-00008","article-title":"Osteofibrous dysplasia and adamantinoma","volume":"18","author":"Most","year":"2010","journal-title":"J Am Acad Orthop Surg."},{"issue":"5","key":"bib4-20230811","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1302\/0301-620X.88B5.17358","article-title":"Osteofibrous dysplasia of the tibia. Is there a need for a radical surgical approach?","volume":"88","author":"Lee","year":"2006","journal-title":"J Bone Joint Surg Br."},{"issue":"3","key":"bib5-20230811","first-page":"409","article-title":"Does osteofibrous dysplasia progress to adamantinoma and how should they be treated? Bone Joint J","volume":"99-B","author":"Scholfield","year":"2017"},{"issue":"8","key":"bib6-20230811","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1007\/s00256-004-0755-0","article-title":"Differentiated adamantinoma of the fibula: a rhabdoid variant","volume":"33","author":"Pov\u00fdsil","year":"2004","journal-title":"Skeletal Radiol."},{"issue":"5","key":"bib7-20230811","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s00256-003-0624-2","article-title":"Adamantinoma, osteofibrous dysplasia and differentiated adamantinoma","volume":"32","author":"Kahn","year":"2003","journal-title":"Skeletal Radiol."}],"container-title":["JBJS Case Connector"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/01709767-201809000-00007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T13:39:42Z","timestamp":1787751582000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/01709767-201809000-00007"}},"subtitle":["A Case Report"],"short-title":[],"issued":{"date-parts":[[2018,7,11]]},"references-count":6,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.2106\/jbjs.cc.17.00294","relation":{},"ISSN":["2160-3251"],"issn-type":[{"value":"2160-3251","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,11]]}}}