{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:42:59Z","timestamp":1787755379249,"version":"build-2784847793"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JBJS Case Connector"],"abstract":"<jats:sec>\n                    <jats:title>Case:<\/jats:title>\n                    <jats:p>We describe the first reported case of scurvy developing secondary to behavioral traits of Jacobsen syndrome. The diagnosis of scurvy was significantly delayed because bleeding symptoms were initially attributed to baseline thrombocytopenia and platelet dysfunction associated with Jacobsen syndrome and patient's medication. Following vitamin C supplementation, signs and symptoms of the patient's disease quickly resolved.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>We aim to reinforce the need to consider nutritional deficiencies in patients with complex medical histories and behavioral issues, especially when presenting with new complaints.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2106\/jbjs.cc.18.00352","type":"journal-article","created":{"date-parts":[[2019,9,20]],"date-time":"2019-09-20T05:09:49Z","timestamp":1568956189000},"page":"e0352-e0352","source":"Crossref","is-referenced-by-count":1,"title":["Scurvy Findings in a Child with Jacobsen Syndrome"],"prefix":"10.2106","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0621-5446","authenticated-orcid":false,"given":"Alan C.","family":"Puddy","sequence":"first","affiliation":[{"name":"United States Air Force Medical Corps, San Antonio Military Medical Center, Fort Sam Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8147-6638","authenticated-orcid":false,"given":"Jessica L.","family":"Hughes","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Baylor Scott and White, Temple, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3261-3824","authenticated-orcid":false,"given":"Avrum L.","family":"Joffe","sequence":"additional","affiliation":[{"name":"North Jersey Pediatric Orthopedics, Ridgewood, New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7819-953X","authenticated-orcid":false,"given":"Paritosh C.","family":"Khanna","sequence":"additional","affiliation":[{"name":"Division of Radiology, Rady Children's Hospital-San Diego, San Diego, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5665-8958","authenticated-orcid":false,"given":"Courtney D.","family":"Thornburg","sequence":"additional","affiliation":[{"name":"Division of Hematology-Oncology, Rady Children's Hospital-San Diego, San Diego, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4582-1297","authenticated-orcid":false,"given":"Scott J.","family":"Mubarak","sequence":"additional","affiliation":[{"name":"Division of Orthopedic Surgery, Rady Children's Hospital-San Diego, San Diego, California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2019]]},"reference":[{"issue":"2","key":"bib1-20230712","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.ejim.2010.10.006","article-title":"Scurvy: past, present and future","volume":"22","author":"Magiorkinis","year":"2011","journal-title":"Eur J Intern Med."},{"issue":"11","key":"bib2-20230712","doi-asserted-by":"crossref","first-page":"E752","DOI":"10.1503\/cmaj.091938","article-title":"Scurvy in the developed world","volume":"183","author":"Smith","year":"2011","journal-title":"Can Med Assoc J."},{"issue":"6","key":"bib3-20230712","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1097\/MPH.0b013e318236c519","article-title":"Scurvy in a child with autism","volume":"34","author":"Niwa","year":"2012","journal-title":"J Pediatr Hematol Oncol."},{"issue":"3","key":"bib4-20230712","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/s00256-011-1350-9","article-title":"Magnetic resonance imaging appearance of scurvy with gelatinous bone marrow transformation","volume":"41","author":"Brennan","year":"2012","journal-title":"Skeletal Radiol."},{"issue":"5","key":"bib5-20230712","doi-asserted-by":"crossref","first-page":"443","DOI":"10.3348\/kjr.2007.8.5.443","article-title":"MR imaging in a child with scurvy: a case report","volume":"8","author":"Choi","year":"2007","journal-title":"Korean J Radiol."},{"issue":"10","key":"bib6-20230712","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1007\/s00247-013-2688-z","article-title":"Scurvy in an autistic child: MRI findings","volume":"43","author":"Gongidi","year":"2013","journal-title":"Pediatr Radiol."},{"issue":"6","key":"bib7-20230712","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1159\/000152624","article-title":"An (11;21) translocation in four generations with chromosome 11 abnormalities in the offspring: a clinical, cytogenetical, and gene marker study","volume":"23","author":"Jacobsen","year":"1973","journal-title":"Hum Hered."},{"issue":"5","key":"bib8-20230712","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.3945\/ajcn.2008.27016","article-title":"Serum vitamin C and the prevalence of vitamin C deficiency in the United States: 2003-2004 National Health and Nutrition Examination Survey (NHANES)","volume":"90","author":"Schleicher","year":"2009","journal-title":"Am J Clin Nutr."},{"issue":"7","key":"bib9-20230712","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1080\/09537100701280670","article-title":"Platelet storage pool deficiency in Jacobsen syndrome","volume":"18","author":"White","year":"2007","journal-title":"Platelets."},{"issue":"4","key":"bib10-20230712","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1056\/NEJMcpc079017","article-title":"Case records of the Massachusetts General Hospital. Case 23-2007: a 9-year-old boy with bone pain, rash, and gingival hypertrophy","volume":"357","author":"Duggan","year":"2007","journal-title":"N Engl J Med."},{"issue":"1","key":"bib11-20230712","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1750-1172-4-9","article-title":"Jacobsen syndrome","volume":"4","author":"Mattina","year":"2009","journal-title":"Orphanet J Rare Dis."},{"issue":"3","key":"bib13-20230712","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.clindermatol.2012.08.001","article-title":"Albert Szent-Gy\u00f6rgyi (1893-1986): the scientist who discovered vitamin C","volume":"31","author":"Grzybowski","year":"2013","journal-title":"Clin Dermatol."},{"issue":"2","key":"bib14-20230712","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1080\/02724936.1989.11748611","article-title":"Scurvy\u2014the eternal masquerader","volume":"9","author":"Gupta","year":"1989","journal-title":"Ann Trop Paediatr."},{"issue":"1","key":"bib15-20230712","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1177\/1533210110392951","article-title":"Vitamin C: overview and update","volume":"16","author":"Schlueter","year":"2011","journal-title":"Evidence Based Complement Altern Med."},{"issue":"2","key":"bib16-20230712","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.jcot.2014.12.003","article-title":"Scurvy in pediatric age group\u2014a disease often forgotten?","volume":"6","author":"Agarwal","year":"2015","journal-title":"J Clin Orthop Trauma."},{"key":"bib17-20230712","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1097\/00003086-198011000-00022","article-title":"Epiphyseometaphyseal cupping of the distal femoral epiphysis following scurvy in infancy","volume":"153","author":"Hallel","year":"1980","journal-title":"Clin Orthop Relat Res."},{"issue":"2","key":"bib18-20230712","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1097\/01241398-198808020-00018","article-title":"Epiphyseal separation in scurvy","volume":"8","author":"Quiles","year":"1988","journal-title":"J Pediatr Orthop."},{"issue":"5","key":"bib19-20230712","doi-asserted-by":"crossref","first-page":"870","DOI":"10.2105\/AJPH.94.5.870","article-title":"Vitamin C deficiency and depletion in the United States: the Third National Health and Nutrition Examination Survey, 1988 to 1994 [corrected] [published erratum appears in Am J Public HEALTH 2004 Jul;94(7):1078]","volume":"94","author":"Hampl","year":"2004","journal-title":"Am J Public Health."},{"issue":"2","key":"bib20-20230712","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.jada.2009.10.032","article-title":"Food selectivity and sensory sensitivity in children with autism spectrum disorders","volume":"110","author":"Cermak","year":"2010","journal-title":"J Am Diet Assoc."}],"container-title":["JBJS Case Connector"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.2106\/JBJS.CC.18.00352","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T13:42:02Z","timestamp":1787751722000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.2106\/JBJS.CC.18.00352"}},"subtitle":["A Case Report"],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":19,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2019]]}},"URL":"https:\/\/doi.org\/10.2106\/jbjs.cc.18.00352","relation":{},"ISSN":["2160-3251"],"issn-type":[{"value":"2160-3251","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]}}}