{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:46:52Z","timestamp":1787755612834,"version":"build-2784847793"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:sec>\n                    <jats:title>Case:<\/jats:title>\n                    <jats:p>An 11-year-old child who presented with a postseptic gap nonunion of 4 cm in the proximal humerus was treated with a customized hydroxyapatite-tricalcium phosphate-tricalcium silicate composite (HASi) scaffold loaded with culture-expanded autologous bone marrow\u2013derived mesenchymal stem cells (MSCs) primed into osteogenic lineage. Union occurred at 3 months, and at 3 years, the child had improved joint mobility, with radiographic and computed tomographic imaging evidence of incorporation of the graft.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>This case demonstrated the feasibility of MSC directed into osteogenic lineage on HASi to repair a long bone defect owing to postseptic osteomyelitis, a condition notorious for a high failure rate.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2106\/jbjs.cc.19.00031","type":"journal-article","created":{"date-parts":[[2020,3,20]],"date-time":"2020-03-20T06:14:20Z","timestamp":1584684860000},"page":"e0031-e0031","source":"Crossref","is-referenced-by-count":4,"title":["First Report of a Tissue-Engineered Graft for Proximal Humerus Gap Non-union After Chronic Pyogenic Osteomyelitis in a Child"],"prefix":"10.2106","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4494-222X","authenticated-orcid":false,"given":"Vrisha","family":"Madhuri","sequence":"first","affiliation":[{"name":"Paediatric Orthopaedics unit, Christian Medical College Hospital, Vellore, Tamil Nadu, India"},{"name":"Centre for Stem Cell Research, a unit of inStem, Bengaluru, Christian Medical College, Bagayam, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4086-9603","authenticated-orcid":false,"given":"Sowmya","family":"Ramesh","sequence":"additional","affiliation":[{"name":"Paediatric Orthopaedics unit, Christian Medical College Hospital, Vellore, Tamil Nadu, India"},{"name":"Centre for Stem Cell Research, a unit of inStem, Bengaluru, Christian Medical College, Bagayam, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9611-2482","authenticated-orcid":false,"given":"Harikrishna","family":"Varma","sequence":"additional","affiliation":[{"name":"Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences & Technology, Thiruvananthapuram, Kerala"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7430-4945","authenticated-orcid":false,"given":"Suresh Babu","family":"Sivadasan","sequence":"additional","affiliation":[{"name":"Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences & Technology, Thiruvananthapuram, Kerala"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2339-3738","authenticated-orcid":false,"given":"Bibhudatta","family":"Sahoo","sequence":"additional","affiliation":[{"name":"Paediatric Orthopaedics unit, Christian Medical College Hospital, Vellore, Tamil 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