{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:46:10Z","timestamp":1787755570760,"version":"build-2784847793"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:sec>\n                    <jats:title>Case:<\/jats:title>\n                    <jats:p>\n                      We describe the case of an 85-year-old woman who presented with worsening right hip pain after a conversion hip replacement. Subsequent imaging demonstrated a gas-containing collection in the lateral thigh. She was taken to the operating room for irrigation and debridement, where intraoperative cultures returned positive for\n                      <jats:italic toggle=\"yes\">Clostridium difficile.<\/jats:italic>\n                      Surgical management was followed by a prolonged course of antibiotics.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      <jats:italic toggle=\"yes\">Clostridium difficile<\/jats:italic>\n                      as the etiology of infection in a conversion arthroplasty is exceedingly rare. Orthopaedic surgeons and infectious disease specialists should consider\n                      <jats:italic toggle=\"yes\">C. diff<\/jats:italic>\n                      as a potential cause of infection in conversion hip arthroplasty because management options will need to be tailored.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.2106\/jbjs.cc.19.00226","type":"journal-article","created":{"date-parts":[[2020,3,24]],"date-time":"2020-03-24T00:10:53Z","timestamp":1585008653000},"page":"e0266-e0266","source":"Crossref","is-referenced-by-count":2,"title":["Clostridium difficile Infection of a Total Hip Arthroplasty"],"prefix":"10.2106","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4802-3354","authenticated-orcid":false,"given":"Justin","family":"Loloi","sequence":"first","affiliation":[{"name":"Penn State College of Medicine, Department of Internal Medicine, Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3860-1309","authenticated-orcid":false,"given":"Oliver","family":"Mrowczynski","sequence":"additional","affiliation":[{"name":"Penn State College of Medicine, Department of Internal Medicine, Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1492-3530","authenticated-orcid":false,"given":"Benjamin","family":"Claxton","sequence":"additional","affiliation":[{"name":"Penn State College of Medicine, Department of Internal Medicine, Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2506-2019","authenticated-orcid":false,"given":"Muhammad","family":"Abdulbasit","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4751-3060","authenticated-orcid":false,"given":"Meredith","family":"Schade","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Epidemiology, Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2020]]},"reference":[{"key":"bib1-20230720","first-page":"287","article-title":"Clostridium difficile infection","volume":"373","author":"Leffler","year":"2015","journal-title":"N Engl J Med United States."},{"issue":"4","key":"bib2-20230720","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1038\/ajg.2013.4","article-title":"Guidelines for diagnosis, treatment, and prevention of Clostridium difficile infections","volume":"108","author":"Surawicz","year":"2013","journal-title":"Am J Gastroenterol."},{"key":"bib3-20230720","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1146\/annurev.med.49.1.375","article-title":"Clostridium difficile infection","volume":"49","author":"Kelly","year":"1998","journal-title":"Annu Rev Med."},{"issue":"8","key":"bib4-20230720","first-page":"1746","article-title":"The impact of infection 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Orthop Relat Res."},{"issue":"2","key":"bib8-20230720","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1128\/JCM.01762-07","article-title":"Evaluation of quantitative analysis of cultures from sonicated retrieved orthopedic implants in diagnosis of orthopedic infection","volume":"46","author":"Esteban","year":"2008","journal-title":"J Clin Microbiol."},{"issue":"2","key":"bib9-20230720","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1128\/CMR.00111-13","article-title":"Prosthetic joint infection","volume":"27","author":"Tande","year":"2014","journal-title":"Clin Microbiol Rev."},{"issue":"6","key":"bib10-20230720","doi-asserted-by":"crossref","first-page":"e148","DOI":"10.1093\/cid\/cit392","article-title":"Extraintestinal Clostridium difficile infections","volume":"57","author":"Mattila","year":"2013","journal-title":"Clin Infect Dis."},{"issue":"11","key":"bib11-20230720","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1016\/j.mayocp.2014.07.012","article-title":"Extraintestinal Clostridium difficile infections: a single-center experience","volume":"89","author":"Gupta","year":"2014","journal-title":"Mayo Clin Proc."},{"key":"bib12-20230720","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.anaerobe.2014.03.007","article-title":"Early infection of hip joint prosthesis by Clostridium difficile in an HIV-1 infected patient","volume":"27","author":"Brassinne","year":"2014","journal-title":"Anaerobe."},{"issue":"7","key":"bib13-20230720","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1007\/BF01690732","article-title":"Chronic septic arthritis and osteomyelitis in a prosthetic knee joint due to Clostridium difficile","volume":"14","author":"Pron","year":"1995","journal-title":"Eur J Clin Microbiol Infect 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management of prosthetic joint infection: clinical practice guidelines by the Infectious Diseases Society of America","volume":"56","author":"Osmon","year":"2013","journal-title":"Clin Infect Dis."}],"container-title":["JBJS Case Connector"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.2106\/JBJS.CC.19.00226","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T13:45:14Z","timestamp":1787751914000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.2106\/JBJS.CC.19.00226"}},"subtitle":["Case Report and Review of the Literature"],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":20,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.2106\/jbjs.cc.19.00226","relation":{},"ISSN":["2160-3251"],"issn-type":[{"value":"2160-3251","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]}}}