{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:46:33Z","timestamp":1787755593940,"version":"build-2784847793"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:sec>\n                    <jats:title>Case:<\/jats:title>\n                    <jats:p>\n                      We report the case of a 78-year-old woman with undifferentiated pleomorphic sarcoma (UPS) of the proximal femur arising in a previous site of fibrous dysplasia (i.e., a liposclerosing myxofibrous tumor) that had been treated 4 years earlier with curetted surgery.\n                      <jats:italic toggle=\"yes\">GNAS<\/jats:italic>\n                      mutation was detected in both the previous benign lesion and the UPS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Genetic analysis is useful in demonstrating the origin of the tumor especially in fibrous dysplasia with severe degeneration that have undergone malignant transformation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2106\/jbjs.cc.20.00157","type":"journal-article","created":{"date-parts":[[2020,10,16]],"date-time":"2020-10-16T14:15:16Z","timestamp":1602857716000},"page":"e20.00157-e20.00157","source":"Crossref","is-referenced-by-count":3,"title":["Undifferentiated Pleomorphic Sarcoma Arising in a Fibrous Dysplasia Confirmed by GNAS Mutation Analysis"],"prefix":"10.2106","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7882-4902","authenticated-orcid":false,"given":"Miho","family":"Okuda","sequence":"first","affiliation":[{"name":"Department of Radiology, Kanazawa University Hospital, Kanazawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7759-399X","authenticated-orcid":false,"given":"Satoshi","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Quantum Medical Technology, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9413-3431","authenticated-orcid":false,"given":"Toshifumi","family":"Gabata","sequence":"additional","affiliation":[{"name":"Department of Radiology, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7250-625X","authenticated-orcid":false,"given":"Norio","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Advanced and Innovative Musculoskeletal Medicine, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1236-4162","authenticated-orcid":false,"given":"Takayuki","family":"Nojima","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology, Kanazawa University Hospital, Kanazawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2020]]},"reference":[{"issue":"11","key":"bib3-20230719","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/S0046-8177(03)00430-1","article-title":"Activating Gs alpha mutation at the Arg201 codon in liposclerosing myxofibrous tumor","volume":"34","author":"Matsuba","year":"2003","journal-title":"Hum Pathol."},{"key":"bib4-20230719","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1359\/jbmr.060818","article-title":"Monostotic fibrous dysplasia of the proximal femur and liposclerosing myxofibrous tumor: which one is 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