{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:45:55Z","timestamp":1787755555538,"version":"build-2784847793"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec>\n                    <jats:title>Case:<\/jats:title>\n                    <jats:p>Gorham-Stout disease (GSD) is a rare disorder characterized by progressive localized osteolysis and lymphatic malformation. A 26-year-old woman with GSD presented to our hospital with a Cobb angle of 100\u00b0 and a kyphosis angle of 88\u00b0. Everolimus therapy was initiated to control the disease prior to surgery. After halo-gravity traction for 4 weeks, we performed anterior and posterior spinal fusion. Postoperative computed tomography revealed satisfactory bone union and no significant loss of correction 1 year post-surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This case suggests that anterior and posterior spinal fusion combined with everolimus therapy can be a therapeutic option for GSD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2106\/jbjs.cc.20.00296","type":"journal-article","created":{"date-parts":[[2021,3,3]],"date-time":"2021-03-03T14:14:55Z","timestamp":1614780895000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":7,"title":["Gorham-Stout Disease Resulting in Spinal Deformity Treated by Fusion Surgery Combined With Everolimus Therapy"],"prefix":"10.2106","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5692-768X","authenticated-orcid":false,"given":"Akira","family":"Toga","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery, Keio University School of Medicine, Shinjuku, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4830-4690","authenticated-orcid":false,"given":"Kota","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Keio University School of Medicine, Shinjuku, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1977-2698","authenticated-orcid":false,"given":"Satoshi","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Keio University School of Medicine, Shinjuku, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6406-1836","authenticated-orcid":false,"given":"Satoshi","family":"Nori","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Keio University School of Medicine, Shinjuku, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osahiko","family":"Tsuji","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Keio University School of Medicine, Shinjuku, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2865-3655","authenticated-orcid":false,"given":"Narihito","family":"Nagoshi","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Keio University School of Medicine, Shinjuku, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0402-0389","authenticated-orcid":false,"given":"Eijiro","family":"Okada","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Keio University School of Medicine, Shinjuku, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2324-3780","authenticated-orcid":false,"given":"Mitsuru","family":"Yagi","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Keio University School of Medicine, Shinjuku, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8658-2088","authenticated-orcid":false,"given":"Nobuyuki","family":"Fujita","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Keio University School of Medicine, Shinjuku, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7916-5497","authenticated-orcid":false,"given":"Masaya","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Keio University School of Medicine, Shinjuku, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1934-6998","authenticated-orcid":false,"given":"Morio","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Keio University School of Medicine, Shinjuku, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2021,1]]},"reference":[{"issue":"4","key":"bib1-20240807","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1089\/lrb.2011.0020","article-title":"Lymphangiomatosis: clinical overview","volume":"9","author":"Blei","year":"2011","journal-title":"Lymphat Res Biol."},{"key":"bib2-20240807","first-page":"368","article-title":"A singular case of absorption of bone (a boneless arm)","volume":"18","author":"Jackson","year":"1838","journal-title":"Boston Med Surg J."},{"key":"bib3-20240807","first-page":"245","article-title":"Absorption of the humerus after fracture","volume":"10","author":"Jackson","year":"1872","journal-title":"Boston Med Surg J."},{"issue":"5","key":"bib4-20240807","doi-asserted-by":"crossref","first-page":"985","DOI":"10.2106\/00004623-195537050-00008","article-title":"Massive osteolysis (acute spontaneous absorption of bone, phantom bone, disappearing bone); its relation to hemangiomatosis","volume":"37","author":"Gorham","year":"1955","journal-title":"J Bone Joint Surg Am."},{"issue":"5","key":"bib5-20240807","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/0002-9343(54)90027-3","article-title":"Disappearing bones: a rare form of massive osteolysis; report of two cases, one with autopsy findings","volume":"17","author":"Gorham","year":"1954","journal-title":"Am J Med."},{"issue":"5","key":"bib6-20240807","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1002\/pbc.25914","article-title":"Clinical features and prognosis of generalized lymphatic anomaly, kaposiform lymphangiomatosis, and Gorham-Stout disease","volume":"63","author":"Ozeki","year":"2016","journal-title":"Pediatr Blood Cancer."},{"issue":"6","key":"bib7-20240807","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1089\/wound.2018.0850","article-title":"Generalized lymphatic anomaly and Gorham-Stout disease: overview and recent insights","volume":"8","author":"Ozeki","year":"2019","journal-title":"Adv Wound Care (New Rochelle)."},{"issue":"5","key":"bib8-20240807","doi-asserted-by":"crossref","first-page":"694","DOI":"10.5312\/wjo.v5.i5.694","article-title":"Vanishing bone disease (Gorham-Stout syndrome): a review of a rare entity","volume":"5","author":"Nikolaou","year":"2014","journal-title":"World J Orthop."},{"key":"bib9-20240807","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1148\/82.4.637","article-title":"Massive osteolysis and angiomatosis","volume":"82","author":"Halliday","year":"1964","journal-title":"Radiology."},{"issue":"12","key":"bib10-20240807","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1016\/j.crad.2006.04.014","article-title":"Gorham disease of bone: three cases and review of radiological features","volume":"61","author":"Kai","year":"2006","journal-title":"Clin Radiol."},{"issue":"1","key":"bib11-20240807","doi-asserted-by":"crossref","first-page":"121","DOI":"10.3233\/NRE-130935","article-title":"Gorham's disease of the spine","volume":"33","author":"Barman","year":"2013","journal-title":"NeuroRehabilitation."},{"issue":"1","key":"bib12-20240807","doi-asserted-by":"crossref","first-page":"e5","DOI":"10.1016\/j.spinee.2013.07.451","article-title":"Gorham disease of the lumbar spine with an abdominal aortic aneurysm: a case report","volume":"14","author":"Kakuta","year":"2014 Jan","journal-title":"Spine J."},{"issue":"4","key":"bib13-20240807","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1620\/tjem.241.249","article-title":"Successful management of Gorham-Stout disease in the cervical spine by combined conservative and surgical treatments: a case report","volume":"241","author":"Tateda","year":"2017","journal-title":"Tohoku J Exp Med."},{"issue":"1","key":"bib14-20240807","doi-asserted-by":"crossref","first-page":"107","DOI":"10.4103\/0019-5413.197559","article-title":"Vanishing bone disease of chest wall and spine with kyphoscoliosis and neurological deficit: a case report and review of literature","volume":"51","author":"Srivastava","year":"2017","journal-title":"Indian J Orthop."},{"issue":"4","key":"bib15-20240807","doi-asserted-by":"crossref","first-page":"448","DOI":"10.2340\/00015555-2300","article-title":"Efficacy and safety of mammalian target of rapamycin inhibitors in vascular anomalies: a systematic review","volume":"96","author":"Nadal","year":"2016","journal-title":"Acta Derm Venereol."},{"issue":"3","key":"bib16-20240807","doi-asserted-by":"crossref","first-page":"e70","DOI":"10.2106\/JBJS.CC.17.00287","article-title":"Sirolimus therapy as perioperative treatment of gorham-stout disease in the thoracic spine: a case report","volume":"8","author":"Mo","year":"2018","journal-title":"JBJS Case Connect."},{"issue":"24","key":"bib17-20240807","doi-asserted-by":"crossref","first-page":"3011","DOI":"10.4161\/cc.6.24.5085","article-title":"All roads lead to mTOR: integrating inflammation and tumor angiogenesis","volume":"6","author":"Lee","year":"2007","journal-title":"Cell Cycle."},{"issue":"7","key":"bib18-20240807","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1007\/s00256-012-1565-4","article-title":"Gorham-Stout disease and generalized lymphatic anomaly\u2014clinical, radiologic, and histologic differentiation","volume":"42","author":"Lala","year":"2013","journal-title":"Skeletal Radiol."}],"container-title":["JBJS Case Connector"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.2106\/JBJS.CC.20.00296","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T13:44:16Z","timestamp":1787751856000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.2106\/JBJS.CC.20.00296"}},"subtitle":["A Case Report"],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":18,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.2106\/jbjs.cc.20.00296","relation":{},"ISSN":["2160-3251"],"issn-type":[{"value":"2160-3251","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1]]}}}