{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:46:09Z","timestamp":1787755569526,"version":"build-2784847793"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:sec>\n                    <jats:title>Case:<\/jats:title>\n                    <jats:p>Stiff-person syndrome (SPS) presents with progressive muscle rigidity, postural instability, and periodic debilitating spasms. Reports of axial hyperextension exist, but kyphotic deformities have not been described. We surgically treated a patient with debilitating SPS and severe cervicothoracic hyperkyphosis with posterior spinal fusion and instrumentation. At 1-year follow-up, the patient displayed better upright gait and forward gaze, 18\u00b0 cervical lordosis, and improved patient-reported outcome scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>SPS can lead to extreme spinal deformity and disease, including hyperkyphosis of the cervicothoracic spine, and can successfully be managed with a multidisciplinary team and a posterior-only correction with spinal instrumentation and fusion.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2106\/jbjs.cc.20.00378","type":"journal-article","created":{"date-parts":[[2020,12,10]],"date-time":"2020-12-10T18:05:01Z","timestamp":1607623501000},"page":"e20.00378-e20.00378","source":"Crossref","is-referenced-by-count":1,"title":["Severe Chin-on-Chest Cervical Spine Deformity in the Setting of Stiff-Person Syndrome"],"prefix":"10.2106","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2079-8657","authenticated-orcid":false,"given":"Stephen R.","family":"Stephan","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, Cedars-Sinai Medical Center, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4860-2281","authenticated-orcid":false,"given":"Derek G.","family":"Ju","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Cedars-Sinai Medical Center, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1685-6893","authenticated-orcid":false,"given":"Lindsey B.","family":"Ross","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4328-9943","authenticated-orcid":false,"given":"Robert T.","family":"Naruse","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, Cedars-Sinai Medical Center, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7855-6346","authenticated-orcid":false,"given":"Terrence T.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Cedars-Sinai Medical Center, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5690-5982","authenticated-orcid":false,"given":"J. Patrick","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2020]]},"reference":[{"issue":"2","key":"bib1-20230719","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1007\/s11940-009-0013-9","article-title":"Stiff person syndrome: advances in pathogenesis and therapeutic interventions","volume":"11","author":"Dalakas","year":"2009","journal-title":"Curr Treat Options Neurol."},{"key":"bib2-20230719","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.jns.2019.06.021","article-title":"SPS: understanding the complexity","volume":"404","author":"El-Abassi","year":"2019","journal-title":"J Neurol Sci."},{"key":"bib3-20230719","doi-asserted-by":"crossref","first-page":"116624","DOI":"10.1016\/j.jns.2019.116624","article-title":"Molecular mechanisms responsible for stiff-person syndrome","volume":"409","author":"Ahmed","year":"2020","journal-title":"J Neurol Sci."},{"issue":"5","key":"bib4-20230719","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1111\/j.1528-1167.2009.02325.x","article-title":"Clinical significance of glutamic acid decarboxylase antibodies in patients with epilepsy","volume":"51","author":"Liimatainen","year":"2010","journal-title":"Epilepsia."},{"issue":"3","key":"bib5-20230719","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1002\/mds.870080323","article-title":"Significant improvement of stiff-person syndrome after paraspinal injection of botulinum toxin A","volume":"8","author":"Davis","year":"1993","journal-title":"Mov Disord."},{"issue":"8","key":"bib6-20230719","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/ncpneuro0259","article-title":"Sudden spasms following gradual lordosis: the stiff-person syndrome","volume":"2","author":"Wilson","year":"2006","journal-title":"Nat Clin Pract Neurol."},{"issue":"2","key":"bib7-20230719","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/S1297-319X(02)00374-3","article-title":"Atypical low back pain: stiff-person syndrome","volume":"69","author":"Gallien","year":"2002","journal-title":"Joint Bone Spine."},{"issue":"15","key":"bib8-20230719","first-page":"421","article-title":"Progressive fluctuating muscular rigidity and spasm (\u201cstiff-man\u201d syndrome); report of a case and some observations in 13 other cases","volume":"31","author":"Moersch","year":"1956","journal-title":"Proc Staff Meet Mayo Clin."},{"key":"bib9-20230719","doi-asserted-by":"crossref","first-page":"577192","DOI":"10.1016\/j.jneuroim.2020.577192","article-title":"Stiff person spectrum disorders: an illustrative case series of their phenotypic and antibody diversity","volume":"341","author":"Bernardo","year":"2020","journal-title":"J Neuroimmunol."},{"issue":"8","key":"bib10-20230719","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1136\/jnnp-2014-309201","article-title":"Stiff-person syndrome: insights into a complex autoimmune disorder","volume":"86","author":"Baizabal-Carvallo","year":"2015","journal-title":"J Neurol Neurosurg Psychiatry."}],"container-title":["JBJS Case Connector"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.2106\/JBJS.CC.20.00378","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T13:44:42Z","timestamp":1787751882000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.2106\/JBJS.CC.20.00378"}},"subtitle":["A Case Report"],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":10,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.2106\/jbjs.cc.20.00378","relation":{},"ISSN":["2160-3251"],"issn-type":[{"value":"2160-3251","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]}}}