{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:44:44Z","timestamp":1787755484538,"version":"build-2784847793"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec>\n                    <jats:title>Case:<\/jats:title>\n                    <jats:p>Malignant granular cell tumors are uncommon soft-tissue tumors. We describe a granular cell tumor that presented as a benign hand nodule diagnosed by biopsy and image. The patient refused local excision. After 15 years, the patient came back because of symptomatic growth, and a malignant granular cell tumor was diagnosed, with metastatic disease. Despite surgical disarticulation and adjuvant treatment, she died after 8 months. The pathological examination revealed the tumor had progressed to malignant behavior.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Our findings highlight the importance of a closer follow-up. Although unusual, we must be aware of the possibility of a change of behavior from benign to malignant granular cell tumor.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2106\/jbjs.cc.20.00503","type":"journal-article","created":{"date-parts":[[2022,1,31]],"date-time":"2022-01-31T23:00:58Z","timestamp":1643670058000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Granular Cell Tumor of the Hand: Unusual Malignancy of a Previous Benign Lesion"],"prefix":"10.2106","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3343-8485","authenticated-orcid":false,"given":"Cristina","family":"Dauder Gallego","sequence":"first","affiliation":[{"name":"Department of Hand Orthopaedic Surgery, Hospital Universitario Fundaci\u00f3n Alcorc\u00f3n, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1033-0412","authenticated-orcid":false,"given":"Jorge","family":"Ruiz Zafra","sequence":"additional","affiliation":[{"name":"Department of Hand Orthopaedic Surgery, Hospital Universitario Fundaci\u00f3n Alcorc\u00f3n, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3754-519X","authenticated-orcid":false,"given":"Ramona Ionela","family":"Stanescu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hospital Universitario Fundaci\u00f3n Alcorc\u00f3n, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2857-436X","authenticated-orcid":false,"given":"Mar\u00eda","family":"Trujillo Coronado","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hospital Universitario Fundaci\u00f3n Alcorc\u00f3n, Madrid, 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