{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:39:06Z","timestamp":1787755146185,"version":"build-2784847793"},"reference-count":14,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec>\n                    <jats:title>Case:<\/jats:title>\n                    <jats:p>A 37-year-old man presented with pain and macrodactyly of a toe. Imaging and histology demonstrated findings consistent with macrodystrophia lipomatosa (MDL). We compared our findings with control tissue obtained from an identical site of a fresh-frozen cadaveric foot from the same anatomical site. Pacinian corpuscles (PCs) in the MDL tissue were increased in number, size, and shape compared with the control tissue and demonstrated edematous interstitial lamellae and vacuolar degenerative change. We also document the magnetic resonance imaging findings of the PCs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Peculiar abnormalities of PCs in MDL underline nerve damage and may be a contributing factor in the pain associated with this unusual condition.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2106\/jbjs.cc.20.00785","type":"journal-article","created":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T15:39:50Z","timestamp":1623771590000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Macrodystrophia Lipomatosa of the Foot"],"prefix":"10.2106","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1311-343X","authenticated-orcid":false,"given":"Edward J.","family":"Southard","sequence":"first","affiliation":[{"name":"Departments of Orthopaedic Surgery and Radiology, New York Presbyterian Lower Manhattan Hospital, New York, New York"},{"name":"Kingsbrook Jewish Medical Center, Brooklyn, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6781-9868","authenticated-orcid":false,"given":"Andrew K.","family":"Sands","sequence":"additional","affiliation":[{"name":"Departments of Orthopaedic Surgery and Radiology, New York Presbyterian Lower Manhattan Hospital, New York, New York"},{"name":"Kingsbrook Jewish Medical Center, Brooklyn, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9156-7229","authenticated-orcid":false,"given":"David A.","family":"Boyajian","sequence":"additional","affiliation":[{"name":"Departments of Orthopaedic Surgery and Radiology, New York Presbyterian Lower Manhattan Hospital, New York, New York"},{"name":"Kingsbrook Jewish Medical Center, Brooklyn, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3874-9976","authenticated-orcid":false,"given":"Elizabeth","family":"Sieczka","sequence":"additional","affiliation":[{"name":"Departments of Orthopaedic Surgery and Radiology, New York Presbyterian Lower Manhattan Hospital, New York, New York"},{"name":"Kingsbrook Jewish Medical Center, Brooklyn, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3336-0999","authenticated-orcid":false,"given":"Eli","family":"Bryk","sequence":"additional","affiliation":[{"name":"Departments of Orthopaedic Surgery and Radiology, New York Presbyterian Lower Manhattan Hospital, New York, New York"},{"name":"Kingsbrook Jewish Medical Center, Brooklyn, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5648-6199","authenticated-orcid":false,"given":"Vincent J.","family":"Vigorita","sequence":"additional","affiliation":[{"name":"Departments of Orthopaedic Surgery and Radiology, New York Presbyterian Lower Manhattan Hospital, New York, New York"},{"name":"Kingsbrook Jewish Medical Center, Brooklyn, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2021,4]]},"reference":[{"issue":"10","key":"bib1-20240805","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1302\/0301-620X.97B10.35660","article-title":"Ray amputation for the treatment of foot macrodactyly in children","volume":"97-B","author":"Kim","year":"2015","journal-title":"Bone Joint J."},{"issue":"3","key":"bib2-20240805","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s00256-007-0431-2","article-title":"Progressive enlargement of the great toe: presentation, diagnosis and discussion","volume":"37","author":"van Rensburg","year":"2008","journal-title":"Skeletal Radiol."},{"key":"bib3-20240805","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/1824-7288-36-69","article-title":"Macrodystrophia lipomatosa: four case reports","volume":"36","author":"Khan","year":"2010","journal-title":"Ital J Pediatr."},{"issue":"3","key":"bib4-20240805","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1007\/s00256-005-0034-8","article-title":"Lipomatosis of the sciatic nerve: typical and atypical MRI features","volume":"35","author":"Wong","year":"2006","journal-title":"Skeletal Radiol."},{"issue":"3","key":"bib5-20240805","doi-asserted-by":"crossref","first-page":"432","DOI":"10.2106\/00004623-200203000-00015","article-title":"Fibrolipomatous hamartoma in the foot: magnetic resonance imaging and surgical treatment: a report of two cases","volume":"84","author":"Ogose","year":"2002","journal-title":"J Bone Joint Surg Am."},{"issue":"1","key":"bib6-20240805","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1097\/00000478-198501000-00004","article-title":"Fibrolipomatous hamartoma of nerve. A clinicopathologic analysis of 26 cases","volume":"9","author":"Silverman","year":"1985","journal-title":"Am J Surg Pathol."},{"issue":"2","key":"bib7-20240805","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1053\/j.jfas.2006.11.007","article-title":"Lipofibromatous hamartoma of nerve","volume":"46","author":"Taddie","year":"2007","journal-title":"J Foot Ankle Surg."},{"issue":"11","key":"bib8-20240805","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1007\/s00256-003-0684-3","article-title":"Fibrolipomatous hamartoma in the foot: atypical MR imaging findings","volume":"32","author":"Van Breuseghem","year":"2003","journal-title":"Skeletal Radiol."},{"issue":"4","key":"bib10-20240805","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1046\/j.1525-1470.2000.01773.x","article-title":"Macrodactyly: report of eight cases and review of the literature","volume":"17","author":"Krengel","year":"2000","journal-title":"Pediatr Dermatol."},{"issue":"8","key":"bib11-20240805","doi-asserted-by":"crossref","first-page":"e100","DOI":"10.1097\/DAD.0000000000000162","article-title":"Hyperplasia and hypertrophy of pacinian corpuscles: a case report","volume":"37","author":"Garc\u00eda","year":"2015","journal-title":"Am J Dermatopathol."},{"issue":"11","key":"bib12-20240805","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1007\/s00256-018-2934-4","article-title":"Pacinian corpuscles: an explanation for subcutaneous palmar nodules routinely encountered on MR examinations","volume":"47","author":"Rhodes","year":"2018","journal-title":"Skeletal Radiol."},{"issue":"2","key":"bib13-20240805","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1097\/00000372-199804000-00019","article-title":"Painful hyperplasia and hypertrophy of pacinian corpuscles in the hand: report of two cases with immunohistochemical and ultrastructural studies, and a review of the literature","volume":"20","author":"Reznik","year":"1998","journal-title":"Am J Dermatopathol."},{"issue":"9","key":"bib14-20240805","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1097\/DAD.0000000000000374","article-title":"An extraordinary association of glomus tumor and pacinian hyperplasia in the hand of a female patient","volume":"37","author":"Komforti","year":"2015","journal-title":"Am J Dermatopathol."},{"issue":"1","key":"bib15-20240805","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1097\/00007611-197501000-00023","article-title":"Pacinian corpuscle neuroma of digital nerves","volume":"68","author":"Rhode","year":"1975","journal-title":"South Med J."}],"container-title":["JBJS Case Connector"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.2106\/JBJS.CC.20.00785","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T13:38:19Z","timestamp":1787751499000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.2106\/JBJS.CC.20.00785"}},"subtitle":["A Case Report of MRI and Histologic Findings Including Pacinian Corpuscle Abnormalities"],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":14,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.2106\/jbjs.cc.20.00785","relation":{},"ISSN":["2160-3251"],"issn-type":[{"value":"2160-3251","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4]]}}}