{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:45:04Z","timestamp":1787755504024,"version":"build-2784847793"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec>\n                    <jats:title>Case:<\/jats:title>\n                    <jats:p>We report the first case of a 21-year-old male patient with macrodystrophia lipomatosa (MDL), with local gigantism involving the thoracic spine and progressively worsening neurodeficit. Imaging studies revealed fatty infiltration and hypertrophied intercostal nerves, dextroscoliosis, osseous hypertrophy between C4 and T2, and severe canal stenosis at the T4 to T5 level secondary to lamino-facetal hypertrophy. He underwent debulking of the lesion and posterior instrumented decompression in a staged manner. His neurodeficit improved postoperatively and was ambulant without support at the end of the 2-year follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Surgery in patients with MDL is technically challenging and fraught with complications such as neurological deficit and significant blood loss.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2106\/jbjs.cc.20.00821","type":"journal-article","created":{"date-parts":[[2022,1,31]],"date-time":"2022-01-31T23:00:22Z","timestamp":1643670022000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Macrodystrophia Lipomatosa of Thoracic Spine Causing Progressive Neurodeficit"],"prefix":"10.2106","volume":"11","author":[{"given":"Sridhar","family":"Jakkepally","sequence":"first","affiliation":[{"name":"Department of Spine Surgery, Ganga Medical Centre and Hospital Pvt Ltd, Coimbatore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vibhu Krishnan","family":"Viswanathan","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery, Ganga Medical Centre and Hospital Pvt Ltd, Coimbatore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5885-7152","authenticated-orcid":false,"given":"Ajoy P.","family":"Shetty","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery, Ganga Medical Centre and Hospital Pvt Ltd, Coimbatore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pushpa","family":"B T","sequence":"additional","affiliation":[{"name":"Department of radiology, Ganga Medical Centre and Hospital Pvt Ltd, Coimbatore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5817-4909","authenticated-orcid":false,"given":"Rishi M.","family":"Kanna","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery, Ganga Medical Centre and Hospital Pvt Ltd, Coimbatore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6043-006X","authenticated-orcid":false,"given":"Rajasekaran","family":"S","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery, Ganga Medical Centre and Hospital Pvt Ltd, Coimbatore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2021,4]]},"reference":[{"issue":"5","key":"bib1-20240805","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.3171\/2013.12.JNS13174","article-title":"Segmental thoracic lipomatosis of nerve with nerve territory overgrowth: case report","volume":"120","author":"Mahan","year":"2014","journal-title":"J Neurosurg."},{"issue":"4","key":"bib2-20240805","doi-asserted-by":"crossref","first-page":"934","DOI":"10.3171\/2013.7.JNS13537","article-title":"Sciatic nerve lipomatosis and knee osteochondroma: case illustration","volume":"119","author":"Mahan","year":"2013","journal-title":"J Neurosurg."},{"issue":"3","key":"bib3-20240805","doi-asserted-by":"crossref","first-page":"347","DOI":"10.4103\/0019-5154.182469","article-title":"Macrodystrophia lipomatosa: an unusual cause of localized gigantism","volume":"61","author":"Maheswari","year":"2016","journal-title":"Indian J Dermatol."},{"issue":"4","key":"bib4-20240805","doi-asserted-by":"crossref","first-page":"293","DOI":"10.4103\/2229-5178.185465","article-title":"Macrodyastrophia lipomatosa: review of clinico-radio-histopathological features","volume":"7","author":"Majumdar","year":"2016","journal-title":"Indian Dermatol."},{"issue":"4","key":"bib5-20240805","doi-asserted-by":"crossref","first-page":"559","DOI":"10.4103\/ijmpo.ijmpo_65_16","article-title":"Macrodystrophia lipomatosa: clinico-patho-radiological correlation","volume":"38","author":"Mehra","year":"2017","journal-title":"Indian J Med Paediatr Oncol."},{"issue":"4","key":"bib6-20240805","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/s00586-014-3506-5","article-title":"Hyperplasia of rib and vertebra, associated with infiltrating lipoma: a rare case of focal overgrowth","volume":"24","author":"de Poorter","year":"2015","journal-title":"Eur Spine J."},{"issue":"3","key":"bib7-20240805","doi-asserted-by":"crossref","first-page":"933","DOI":"10.3171\/2016.2.JNS151051","article-title":"A new pattern of lipomatosis of nerve: case report","volume":"126","author":"Prasad","year":"2017","journal-title":"J 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Macrodystrophia lipomatosa","volume":"47","author":"Ly","year":"2003","journal-title":"Eur J Radiol."},{"issue":"7","key":"bib13-20240805","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.2106\/00004623-196749070-00001","article-title":"Macrodactyly","volume":"49","author":"Barsky","year":"1967","journal-title":"J Bone Joint Surg Am."}],"container-title":["JBJS Case Connector"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.2106\/JBJS.CC.20.00821","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T13:44:10Z","timestamp":1787751850000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.2106\/JBJS.CC.20.00821"}},"subtitle":["A Case Report and Review of Literature"],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":12,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.2106\/jbjs.cc.20.00821","relation":{},"ISSN":["2160-3251"],"issn-type":[{"value":"2160-3251","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4]]}}}