{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:39:34Z","timestamp":1787755174706,"version":"build-2784847793"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec>\n                    <jats:title>Case:<\/jats:title>\n                    <jats:p>Our patient was a 31-year-old woman with previously undiagnosed panhypopituitarism who presented with bilateral slipped capital femoral epiphysis (SCFE). Together with endocrinology, her treatment plan involved medical management of her panhypopituitarism and surgical correction with femoral neck osteotomy. Hormone deficiencies were corrected 6 weeks after replacement therapy began, and the patient was cleared for surgery. By 5 months after osteotomy, examination revealed delayed union and prominent screws bilaterally. Hardware exchange and repeat internal fixation were then performed. At 8 weeks after revision, she presented with avascular necrosis, and the decision was made to proceed with total hip arthroplasty. A 5-year follow-up period was documented.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This case presented a rare look at SCFE in an adult patient with panhypopituitarism. Other systemic illnesses that can contribute to SCFE or other orthopaedic issues include, but are not limited to, multiple endocrine neoplasia syndromes, vitamin D deficiency, renal osteodystrophy, Kallmann syndrome, Klinefelter syndrome, and pathologies affecting the thyroid and pituitary gland.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2106\/jbjs.cc.20.00940","type":"journal-article","created":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T14:18:45Z","timestamp":1627654725000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Slipped Capital Femoral Epiphysis in an Adult with Panhypopituitarism"],"prefix":"10.2106","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7045-2956","authenticated-orcid":false,"given":"Matthew","family":"Rosen","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, The Florida State University, Tallahassee, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8033-6476","authenticated-orcid":false,"given":"Andrew","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, The Florida State University, Tallahassee, Florida"},{"name":"Tallahassee Orthopaedic Clinic, Tallahassee, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5571-5404","authenticated-orcid":false,"given":"Phillip","family":"Worts","sequence":"additional","affiliation":[{"name":"Tallahassee Orthopaedic Clinic, Tallahassee, Florida"},{"name":"Department of Nutrition, Food and Exercise Sciences, The Florida State University, Tallahassee, Florida"},{"name":"FSU Institute of Sports Sciences and Medicine, Tallahassee, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7417-6581","authenticated-orcid":false,"given":"Hank","family":"Hutchinson","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, The Florida State University, Tallahassee, Florida"},{"name":"Tallahassee Orthopaedic Clinic, Tallahassee, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3017-5912","authenticated-orcid":false,"given":"Kristin","family":"Harmon","sequence":"additional","affiliation":[{"name":"Tallahassee Primary Care Associates, Tallahassee, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2021,7]]},"reference":[{"issue":"2","key":"bib1-20240805","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1302\/1863-2548-11-170025","article-title":"SCFE: clinical aspects, diagnosis, and classification","volume":"11","author":"Millis","year":"2017","journal-title":"J Child Orthop."},{"issue":"1","key":"bib2-20240805","doi-asserted-by":"crossref","first-page":"40","DOI":"10.4081\/reumatismo.2016.860","article-title":"Slipped capital femoral epiphysis in adults: case report and review of literature","volume":"68","author":"Mac\u00eda-Villa","year":"2016","journal-title":"Reumatismo."},{"issue":"10","key":"bib3-20240805","first-page":"e19.00084","article-title":"Slipped capital femoral epiphysis in an adult patient with panhypopitutarism","volume":"3","author":"Gupta","year":"2019","journal-title":"J Am Acad Orthop Surg Glob Res Rev."},{"issue":"3","key":"bib4-20240805","doi-asserted-by":"crossref","first-page":"e13997","DOI":"10.1097\/MD.0000000000013997","article-title":"Slipped capital femoral epiphysis in an adult with congenital hypopituitarism: a case report","volume":"98","author":"Huang","year":"2019","journal-title":"Medicine (Baltimore)."},{"issue":"5","key":"bib6-20240805","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/0022-3468(74)90165-1","article-title":"Epidemiology of slipped capital femoral epiphysis: a review of the literature","volume":"9","author":"Rubin","year":"1974","journal-title":"J Pediatr Surg."},{"issue":"12","key":"bib7-20240805","doi-asserted-by":"crossref","first-page":"3432","DOI":"10.1007\/s11999-012-2452-y","article-title":"Slipped capital femoral epiphysis: prevalence, pathogenesis, and natural history","volume":"470","author":"Novais","year":"2012","journal-title":"Clin Orthop Relat Res."},{"key":"bib8-20240805","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.metabol.2017.10.012","article-title":"Kallmann syndrome: phenotype and genotype of hypogonadotropic hypogonadism","volume":"86","author":"Stamou","year":"2018","journal-title":"Metabolism."},{"issue":"suppl 1","key":"bib9-20240805","doi-asserted-by":"crossref","first-page":"S31","DOI":"10.1007\/s40520-015-0421-5","article-title":"Bone involvement in males with Kallmann disease","volume":"27","author":"Iolascon","year":"2015","journal-title":"Aging Clin Exp Res."},{"issue":"1","key":"bib10-20240805","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1007\/s00776-014-0660-x","article-title":"Delayed-onset of slipped capital femoral epiphysis","volume":"20","author":"Song","year":"2015","journal-title":"J Orthop Sci."},{"issue":"2","key":"bib11-20240805","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.ocl.2015.09.013","article-title":"Complications related to the treatment of slipped capital femoral epiphysis","volume":"47","author":"Roaten","year":"2016","journal-title":"Orthop Clin North Am."},{"issue":"2","key":"bib12-20240805","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1302\/1863-2548-11-170023","article-title":"Histological, histochemical and ultrastructural study of slipped capital femoral epiphysis","volume":"11","author":"Tresoldi","year":"2017","journal-title":"J Child Orthop."},{"issue":"2","key":"bib13-20240805","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/0736-4679(94)00139-1","article-title":"Missed slipped capital femoral epiphysis: illustrative cases and a review","volume":"13","author":"Causey","year":"1995","journal-title":"J Emerg Med."},{"issue":"2","key":"bib14-20240805","first-page":"84","article-title":"Slipped capital femoral epiphysis as manifestation of a rare endocrinological disease","volume":"69","author":"Beukhof","year":"2011","journal-title":"Neth J Med."},{"key":"bib15-20240805","first-page":"567060","article-title":"Painful hip leading to the diagnosis of MEN 2B syndrome","volume":"2012","author":"Ahmad","year":"2012","journal-title":"Case Rep Endocrinol."},{"issue":"4","key":"bib16-20240805","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1210\/er.2018-00126","article-title":"Skeletal and extraskeletal actions of vitamin D: current evidence and outstanding questions","volume":"40","author":"Bouillon","year":"2018","journal-title":"Endocr Rev."},{"issue":"6","key":"bib17-20240805","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1302\/0301-620X.95B6.30806","article-title":"Slipped capital femoral epiphysis associated with vitamin D deficiency","volume":"95-B","author":"Madhuri","year":"2013","journal-title":"Bone Joint J."},{"issue":"3","key":"bib18-20240805","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1097\/BPO.0000000000000435","article-title":"Vitamin D deficiency in slipped upper femoral epiphysis: time to physeal fusion","volume":"36","author":"Judd","year":"2016","journal-title":"J Pediatr Orthop."},{"issue":"6","key":"bib19-20240805","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1097\/MED.0b013e3283400945","article-title":"Renal bone disease","volume":"17","author":"Sprague","year":"2010","journal-title":"Curr Opin Endocrinol Diabetes Obes."},{"issue":"2","key":"bib20-20240805","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1097\/01241398-200303000-00007","article-title":"Outcome of slipped capital femoral epiphysis in renal osteodystrophy","volume":"23","author":"Oppenheim","year":"2003","journal-title":"J Pediatr Orthop."},{"issue":"11","key":"bib21-20240805","doi-asserted-by":"crossref","first-page":"3851","DOI":"10.1210\/jc.2012-2739","article-title":"Metaphyseal bone collapse mimicking slipped capital femoral epiphysis in severe renal osteodystrophy","volume":"97","author":"Takao","year":"2012","journal-title":"J Clin Endocrinol Metab."},{"issue":"2","key":"bib22-20240805","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1097\/00004694-199703000-00013","article-title":"Slipped capital femoral epiphysis associated with renal failure osteodystrophy","volume":"17","author":"Loder","year":"1997","journal-title":"J Pediatr Orthop."},{"issue":"4","key":"bib23-20240805","first-page":"e7718","article-title":"Causes of delayed diagnosis of slipped capital femoral epiphysis: the importance of the frog lateral pelvis projection","volume":"12","author":"Samelis","year":"2020","journal-title":"Cureus."},{"key":"bib24-20240805","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.jpeds.2019.11.037","article-title":"Slipped capital femoral epiphysis in children without obesity","volume":"218","author":"Obana","year":"2020","journal-title":"J Pediatr."},{"issue":"7","key":"bib25-20240805","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1097\/BPO.0000000000000968","article-title":"Comparison of surgical outcomes between a triplane proximal femoral osteotomy and the modified Dunn procedure for stable, moderate to severe slipped capital femoral epiphysis","volume":"39","author":"Sikora-Klak","year":"2019","journal-title":"J Pediatr Orthop."},{"issue":"4","key":"bib26-20240805","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1302\/1863-2548.11.160259","article-title":"Treatment of chronic, stable slipped capital femoral epiphysis via surgical hip dislocation with combined osteochondroplasty and Imhauser osteotomy","volume":"11","author":"Erickson","year":"2017","journal-title":"J Child Orthop."},{"issue":"2","key":"bib27-20240805","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1080\/17453674.2018.1439238","article-title":"Comparison between modified Dunn procedure and in situ fixation for severe stable slipped capital femoral epiphysis","volume":"89","author":"Trisolino","year":"2018","journal-title":"Acta Orthop."},{"key":"bib28-20240805","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1186\/s13018-019-1433-1","article-title":"Outcome of the modified Dunn procedure in severe chronic or acute on chronic slipped capital femoral epiphysis","volume":"14","author":"Ebert","year":"2019","journal-title":"J Orthop Surg Res."},{"issue":"9","key":"bib29-20240805","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1007\/s00132-002-0376-z","article-title":"Results of treating slipped capital femoral epiphysis by pinning in situ [in German]","volume":"31","author":"Arnold","year":"2002","journal-title":"Orthopade."},{"issue":"11","key":"bib30-20240805","doi-asserted-by":"crossref","first-page":"667","DOI":"10.5435\/00124635-201111000-00003","article-title":"Surgical management of healed slipped capital femoral epiphysis","volume":"19","author":"Kuzyk","year":"2011","journal-title":"J Am Acad Orthop Surg."},{"issue":"4","key":"bib31-20240805","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1097\/BPO.0b013e31827d7e06","article-title":"Subcapital correction osteotomy for malunited slipped capital femoral epiphysis","volume":"33","author":"Anderson","year":"2013","journal-title":"J Pediatr Orthop."},{"issue":"11","key":"bib32-20240805","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1302\/0301-620X.96B11.33519","article-title":"Subcapital osteotomy of the femoral neck for patients with healed slipped capital femoral epiphysis","volume":"96-B","author":"Bali","year":"2014","journal-title":"Bone Joint J."}],"container-title":["JBJS Case Connector"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.2106\/JBJS.CC.20.00940","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T13:38:34Z","timestamp":1787751514000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.2106\/JBJS.CC.20.00940"}},"subtitle":["A Case Report"],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":31,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.2106\/jbjs.cc.20.00940","relation":{},"ISSN":["2160-3251"],"issn-type":[{"value":"2160-3251","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7]]}}}