{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:39:22Z","timestamp":1787755162906,"version":"build-2784847793"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec>\n                    <jats:title>Case:<\/jats:title>\n                    <jats:p>A 40-year-old man was admitted to our emergency department with a painful and swollen calf. There was no history of significant trauma, and the physical examination revealed a pulseless, swollen left lower leg. Clinical history revealed a diagnosis of primary myelofibrosis, and magnetic resonance imaging showed a rupture of the gastrocnemius medial head. The diagnosis of spontaneous acute extremity compartment syndrome (AECS) secondary to myelofibrosis was established. An open fasciotomy procedure was performed, and recombinant factor VIIa treatment was applied to control bleeding. Postoperatively, fasciotomy wounds were closed with skin grafts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>AECS may develop in patients with bleeding disorders, and recombinant factor VII may help control bleeding.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2106\/jbjs.cc.21.00337","type":"journal-article","created":{"date-parts":[[2021,7,28]],"date-time":"2021-07-28T15:00:29Z","timestamp":1627484429000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Use of Recombinant Factor VIIa for Bleeding Control in Treatment of Acute Extremity Compartment Syndrome Secondary to Primary Myelofibrosis"],"prefix":"10.2106","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1131-7719","authenticated-orcid":false,"given":"Mehmet","family":"Demirel","sequence":"first","affiliation":[{"name":"Department of Orthopedics and Traumatology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alper \u015e\u00fckr\u00fc","family":"Kendirci","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Traumatology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emre","family":"\u00d6zmen","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Traumatology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f6khan","family":"Polat","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Traumatology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2021,7]]},"reference":[{"issue":"4","key":"bib1-20240805","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1007\/s00264-010-1016-6","article-title":"Acute compartment syndrome in children: a case series in 24 patients and review of the literature","volume":"35","author":"Erd\u00f6s","year":"2011","journal-title":"Int Orthop."},{"issue":"4","key":"bib2-20240805","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/S0363-5023(87)80209-5","article-title":"Forearm compartment syndrome secondary to leukemic infiltrates","volume":"12","author":"Trumble","year":"1987","journal-title":"J Hand Surg Am."},{"issue":"4","key":"bib3-20240805","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1097\/00005131-199012000-00018","article-title":"Compartment syndrome as a presentation of non-Hodgkin's lymphoma","volume":"4","author":"Southworth","year":"1990","journal-title":"J Orthop Trauma."},{"issue":"11","key":"bib4-20240805","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1093\/qjmed\/hcq186","article-title":"Too many platelets to cause compartment syndrome","volume":"104","author":"Teng","year":"2011","journal-title":"QJM."},{"issue":"1","key":"bib5-20240805","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13256-016-0985-5","article-title":"Acute compartment syndrome as the initial manifestation of chronic-phase chronic myeloid leukemia: a case report and review of the literature","volume":"10","author":"Nagase","year":"2016","journal-title":"J Med Case Rep."},{"issue":"1","key":"bib6-20240805","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/S0140-6736(15)00277-9","article-title":"Diagnosis and treatment of acute extremity compartment syndrome","volume":"386","author":"Von Keudell","year":"2015","journal-title":"Lancet."},{"issue":"2","key":"bib7-20240805","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1302\/0301-620X.82B2 .9799","article-title":"Acute compartment syndrome. Who is at risk?","volume":"82","author":"McQueen","year":"2000","journal-title":"J Bone Joint Surg Br."},{"issue":"1","key":"bib8-20240805","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.jemermed.2016.04.001","article-title":"Spontaneous compartment syndrome of the thigh in the absence of trauma","volume":"51","author":"Javedani","year":"2016","journal-title":"J Emerg Med."},{"issue":"1","key":"bib9-20240805","first-page":"134","article-title":"Spontaneous thigh compartment syndrome","volume":"12","author":"Khan","year":"2011","journal-title":"West J Emerg Med."},{"issue":"3","key":"bib10-20240805","first-page":"262","article-title":"A rare case of acquired hemophilia A associated with myelodysplastic syndrome","volume":"5","author":"Raval","year":"2012","journal-title":"Int J Clin Exp Med."},{"issue":"1","key":"bib11-20240805","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1752-1947-8-132","article-title":"Illustrated operative management of spontaneous bleeding and compartment syndrome of the lower extremity in a patient with acquired hemophilia A: a case report","volume":"8","author":"Jentzsch","year":"2014","journal-title":"J Med Case Rep."},{"key":"bib12-20240805","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1016\/S0268-960X(03)90002-6","article-title":"Recombinant factor VIIa (rFVIIa) and its use in severe bleeding in surgery and trauma: a review","volume":"17","author":"Grounds","year":"2003","journal-title":"Blood Rev."},{"issue":"10","key":"bib13-20240805","first-page":"S7","article-title":"Recombinant activated factor VII: its mechanism of action and role in the control of hemorrhage","volume":"49","author":"Allen","year":"2002","journal-title":"Can J Anaesth."},{"issue":"10","key":"bib14-20240805","first-page":"S21","article-title":"A novel hemostatic agent: the potential role of recombinant activated factor VII (rFVIIa) in anesthetic practice","volume":"49","author":"Murkin","year":"2002","journal-title":"Can J Anaesth."},{"issue":"1","key":"bib15-20240805","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13256-016-0897-4","article-title":"Myelofibrosis and acquired hemophilia A: a case report","volume":"10","author":"Wrobel","year":"2016","journal-title":"J Med Case Rep."}],"container-title":["JBJS Case Connector"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.2106\/JBJS.CC.21.00337","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T13:38:33Z","timestamp":1787751513000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.2106\/JBJS.CC.21.00337"}},"subtitle":["A Case Report"],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":15,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.2106\/jbjs.cc.21.00337","relation":{},"ISSN":["2160-3251"],"issn-type":[{"value":"2160-3251","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7]]}}}