{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:45:27Z","timestamp":1787755527334,"version":"build-2784847793"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec>\n                    <jats:title>Case:<\/jats:title>\n                    <jats:p>We describe a case of 2 individually rare diseases existing comorbidly in the form of congenital pseudarthrosis of the tibia (CPT) coincident with cleidocranial dysostosis and provide a review of the literature, including the sole preexisting documented coincidence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      Understanding, treatment, and surgical protocol of CPT have changed considerably since this comorbidity was last reported. Updates include synostosis, periosteal grafting, the use of bone morphogenetic protein, and bisphosphonates. Our case varies from the previous in associated disorder and family history. The relationship between\n                      <jats:italic toggle=\"yes\">CBFA1<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">RUNX2<\/jats:italic>\n                      genes may hold the key, but further study is needed.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.2106\/jbjs.cc.21.00451","type":"journal-article","created":{"date-parts":[[2021,11,4]],"date-time":"2021-11-04T15:00:07Z","timestamp":1636038007000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Congenital Pseudarthrosis of the Tibia Associated With Cleidocranial Dysostosis"],"prefix":"10.2106","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4379-7622","authenticated-orcid":false,"given":"Philip K.","family":"McClure","sequence":"first","affiliation":[{"name":"International Center for Limb Lengthening, Rubin Institute for Advanced Orthopedics, Sinai Hospital of Baltimore, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4076-6601","authenticated-orcid":false,"given":"Jeanne M.","family":"Franzone","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, AI Dupont Hospital for Children, Wilmington, Delaware"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6650-9251","authenticated-orcid":false,"given":"John E.","family":"Herzenberg","sequence":"additional","affiliation":[{"name":"International Center for Limb Lengthening, Rubin Institute for Advanced Orthopedics, Sinai Hospital of Baltimore, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2021,10]]},"reference":[{"issue":"1","key":"bib1-20240805","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1097\/01202412-200001000-00003","article-title":"Congenital pseudarthrosis of the tibia: history, etiology, classification, and epidemiologic data","volume":"9","author":"Hefti","year":"2000","journal-title":"J Pediatr Orthop B."},{"key":"bib3-20240805","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1097\/00003086-198707000-00031","article-title":"Congenital pseudarthrosis of the tibia associated with cleidocranial dysostosis and osteogenesis imperfecta. 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