{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:45:19Z","timestamp":1787755519161,"version":"build-2784847793"},"reference-count":14,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec>\n                    <jats:title>Case:<\/jats:title>\n                    <jats:p>A 47-year-old Japanese woman with a medical history of xanthoma disseminatum (XD) presented with posterior neck pain and abnormal gait without a history of trauma. Imaging studies revealed odontoid process thinning resulting in its fracture due to XD involvement in the atlantoaxial joint and subsequent cervical myelopathy. Posterior C1-C2 fusion surgery improved the patient's symptoms. An XD lesion around the odontoid process was confirmed intraoperatively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>We report cervical myelopathy caused by XD involvement in the C1-C2 joint, showing that early fusion surgery is critical for treating pathological fractures in patients with XD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2106\/jbjs.cc.21.00676","type":"journal-article","created":{"date-parts":[[2022,7,9]],"date-time":"2022-07-09T08:01:06Z","timestamp":1657353666000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Cervical Myelopathy due to Odontoid Fracture Induced by Spinal Involvement of Xanthoma Disseminatum"],"prefix":"10.2106","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3470-5546","authenticated-orcid":false,"given":"Tomoyuki","family":"Asada","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0982-5386","authenticated-orcid":false,"given":"Masao","family":"Koda","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4936-5014","authenticated-orcid":false,"given":"Shin","family":"Teramura","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shohei","family":"Sugita","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8887-1593","authenticated-orcid":false,"given":"Ryota","family":"Matsuoka","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9293-3531","authenticated-orcid":false,"given":"Masashi","family":"Yamazaki","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,7]]},"reference":[{"issue":"8","key":"bib1-20240805","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1001\/archderm.1977.01640080096018","article-title":"Xanthoma disseminatum. Clinical, metabolic, pathologic, and radiologic aspects","volume":"113","author":"Mishkel","year":"1977","journal-title":"Arch Dermatol."},{"issue":"3","key":"bib2-20240805","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1001\/archderm.1938.01480090002001","article-title":"Xanthomatosis: correlation of clinical, histopathologic and chemical studies of cutaneous xanthoma","volume":"37","author":"Montgomery","year":"1938","journal-title":"Arch Derm Syphilol."},{"issue":"1","key":"bib3-20240805","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/s13000-016-0531-1","article-title":"Disseminated intracranial xanthoma disseminatum: a rare case report and review of literature","volume":"11","author":"Yang","year":"2016","journal-title":"Diagn Pathol."},{"issue":"2 pt 2","key":"bib4-20240805","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/0190-9622(90)70218-7","article-title":"Xanthoma disseminatum with progressive involvement of the central nervous and hepatobiliary systems","author":"Knobler","year":"1990","journal-title":"J Am Acad Dermatol."},{"issue":"1","key":"bib5-20240805","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s13256-019-2005-z","article-title":"Osteoarticular lesion in xanthoma disseminatum treated with total hip arthroplasty: a case report","volume":"13","author":"Taniguchi","year":"2019","journal-title":"J Med Case Rep."},{"issue":"1","key":"bib6-20240805","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1111\/pde.12388","article-title":"Xanthoma disseminatum associated with inflammatory arthritis and synovitis\u2014a rare association","volume":"32","author":"Gupta","year":"2015","journal-title":"Pediatr Dermatol."},{"issue":"10","key":"bib7-20240805","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1001\/archderm.1985.01660100093023","article-title":"Bone lesions in xanthoma disseminatum","volume":"121","author":"Blobstein","year":"1985","journal-title":"Arch Dermatol."},{"key":"bib8-20240805","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1046\/j.1440-0960.2003.00676.x","article-title":"Rare association of xanthoma disseminatum with skeletal involvement","volume":"44","author":"Khandpur","year":"2003","journal-title":"Australas J Dermatol."},{"issue":"1","key":"bib9-20240805","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1097\/00043426-199502000-00011","article-title":"Xanthoma disseminatum in an infant with skeletal and marrow involvement","volume":"17","author":"Calverly","year":"1995","journal-title":"J Pediatr Hematol Oncol."},{"issue":"1","key":"bib10-20240805","doi-asserted-by":"crossref","first-page":"208","DOI":"10.4103\/ajns.AJNS_480_20","article-title":"Primary intraosseous xanthogranuloma in adult cervical spine: a case report of benign Cause of lytic bone lesion","volume":"16","author":"Ali","year":"2021","journal-title":"Asian J Neurosurg."},{"issue":"17","key":"bib11-20240805","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1097\/00007632-199509000-00018","article-title":"Primary xanthoma of thoracic spine presenting with myelopathy","volume":"20","author":"Robertson","year":"1995","journal-title":"Spine (Phila Pa 1976)."},{"issue":"3","key":"bib12-20240805","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.bbrc.2004.11.070","article-title":"Crosstalk between cancer cells and bone microenvironment in bone metastasis","volume":"328","author":"Yoneda","year":"2005","journal-title":"Biochem Biophys Res Commun."},{"issue":"1","key":"bib13-20240805","first-page":"1","article-title":"Posterior fusion for fragility type 2 odontoid fractures","volume":"13","author":"Traynelis","year":"2021","journal-title":"J Neurosurg Spine."},{"key":"bib14-20240805","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.wneu.2016.08.100","article-title":"Posterior fixation with C1 lateral mass screws and C2 pars screws for type II odontoid fracture in the elderly: long-term follow-up","volume":"96","author":"Dobran","year":"2016","journal-title":"World Neurosurg."}],"container-title":["JBJS Case Connector"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.2106\/JBJS.CC.21.00676","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T13:44:11Z","timestamp":1787751851000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.2106\/JBJS.CC.21.00676"}},"subtitle":["A Case Report"],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":14,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.2106\/jbjs.cc.21.00676","relation":{},"ISSN":["2160-3251"],"issn-type":[{"value":"2160-3251","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7]]}}}