{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:42:39Z","timestamp":1787755359205,"version":"build-2784847793"},"reference-count":53,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec>\n                    <jats:title>Case:<\/jats:title>\n                    <jats:p>We present a 23-year-old man with acute-on-chronic shoulder pain with an aggressive-appearing, destructive lesion of the left proximal humerus and diffuse lung metastases. Biopsy revealed conventional giant cell tumor of bone (GCTB) without sarcomatous differentiation, treated with resection and proximal humerus reconstruction. Without systemic treatment, his pulmonary metastases demonstrated modest spontaneous regression, with no impairment of pulmonary function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Although GCTB is known to metastasize to lungs, these deposits most commonly follow local recurrence. We describe a young adult with diffuse pulmonary nodules at initial presentation, although still following an indolent clinical course without the need for additional systemic therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2106\/jbjs.cc.22.00496","type":"journal-article","created":{"date-parts":[[2023,2,23]],"date-time":"2023-02-23T11:00:09Z","timestamp":1677150009000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Diffuse Pulmonary Metastases at Presentation of Giant Cell Tumor of Bone"],"prefix":"10.2106","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8821-6866","authenticated-orcid":false,"given":"Christopher R.","family":"Leland","sequence":"first","affiliation":[{"name":"Division of Orthopaedic Oncology, Department of Orthopaedic Surgery, The Johns Hopkins Hospital, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7116-0605","authenticated-orcid":false,"given":"Christine A.","family":"Pratilas","sequence":"additional","affiliation":[{"name":"Division of Pediatric Oncology, Department of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4444-0297","authenticated-orcid":false,"given":"John M.","family":"Gross","sequence":"additional","affiliation":[{"name":"Division of Surgical Pathology, Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0450-7821","authenticated-orcid":false,"given":"Adam S.","family":"Levin","sequence":"additional","affiliation":[{"name":"Division of Orthopaedic Oncology, Department of Orthopaedic Surgery, The Johns Hopkins Hospital, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,1]]},"reference":[{"issue":"8","key":"bib1-20240731","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1001\/jama.1949.02910080034011","article-title":"Giant cell tumor of bone","volume":"141","author":"Hammond","year":"1949","journal-title":"J Am Med Assoc."},{"issue":"2","key":"bib2-20240731","doi-asserted-by":"crossref","first-page":"167","DOI":"10.2106\/00004623-197557020-00007","article-title":"Giant-cell tumor of bone. 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