{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:43:40Z","timestamp":1787755420407,"version":"build-2784847793"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec>\n                    <jats:title>Case:<\/jats:title>\n                    <jats:p>A 68-year-old woman underwent an anterior cervical discectomy and fusion for cervical radiculopathy and subsequently developed a severe contact hypersensitivity reaction in response to Dermabond Prineo, beginning 10 days postoperatively. The Dermabond Prineo mesh was removed, and the patient was treated symptomatically with diphenhydramine, systemic steroids, and oral antibiotics, with complete resolution of her symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This is the first reported contact hypersensitivity reaction to Dermabond Prineo in the context of spine surgery. Surgeons should be able to recognize this presentation and treat this appropriately.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2106\/jbjs.cc.22.00668","type":"journal-article","created":{"date-parts":[[2023,3,9]],"date-time":"2023-03-09T14:04:00Z","timestamp":1678370640000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":8,"title":["Severe Hypersensitivity Reaction to Dermabond Prineo After Anterior Cervical Discectomy and Fusion"],"prefix":"10.2106","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1799-8703","authenticated-orcid":false,"given":"Andrew S","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, Louisiana State University Health Sciences Center, Shreveport, Louisiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6094-8395","authenticated-orcid":false,"given":"Tara A.","family":"Saxena","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Louisiana State University Health Sciences Center, Shreveport, Louisiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2791-7225","authenticated-orcid":false,"given":"Tunde","family":"Abubakar","sequence":"additional","affiliation":[{"name":"Louisiana State University Health Shreveport School of Medicine, Shreveport, Louisiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8351-1302","authenticated-orcid":false,"given":"Phillip Garrett","family":"Fincher","sequence":"additional","affiliation":[{"name":"Louisiana State University Health Shreveport School of Medicine, Shreveport, Louisiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8637-0122","authenticated-orcid":false,"given":"Patrick Allan","family":"Massey","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Louisiana State University Health Sciences Center, Shreveport, Louisiana"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,1]]},"reference":[{"issue":"3","key":"bib1-20240731","first-page":"e14090","article-title":"Contact dermatitis and medical adhesives: a review","volume":"13","author":"Thornton","year":"2021","journal-title":"Cureus."},{"issue":"11","key":"bib2-20240731","doi-asserted-by":"crossref","first-page":"931","DOI":"10.5312\/wjo.v12.i11.931","article-title":"Allergic dermatitis after knee arthroscopy with repeated exposure to Dermabond Prineo in pediatric patients: two case reports","volume":"12","author":"Robinson","year":"2021","journal-title":"World J Orthop."},{"issue":"2","key":"bib3-20240731","doi-asserted-by":"crossref","first-page":"101","DOI":"10.7150\/jbji.42079","article-title":"Wound complications after 2-octyl skin closure systems for total joint arthroplasty","volume":"5","author":"Michalowitz","year":"2020","journal-title":"J Bone Jt Infect."},{"issue":"12","key":"bib4-20240731","doi-asserted-by":"crossref","first-page":"3742","DOI":"10.1016\/j.arth.2017.07.012","article-title":"Characterizing the diagnosis and treatment of allergic contact dermatitis to 2-octyl cyanoacrylate used for skin closure in elective orthopedic surgery","volume":"32","author":"Chalmers","year":"2017","journal-title":"J Arthroplasty."},{"issue":"2","key":"bib5-20240731","doi-asserted-by":"crossref","first-page":"e39","DOI":"10.2106\/JBJS.CC.17.00064","article-title":"Allergic dermatitis after total knee arthroplasty using the Prineo wound-closure device: a report of three cases","volume":"7","author":"Chan","year":"2017","journal-title":"JBJS Case Connect."},{"issue":"20","key":"bib6-20240731","doi-asserted-by":"crossref","first-page":"e26053","DOI":"10.1097\/MD.0000000000026053","article-title":"Postoperative contact dermatitis caused by skin adhesives used in orthopedic surgery: incidence, characteristics, and difference from surgical site infection","volume":"100","author":"So","year":"2021","journal-title":"Medicine (Baltimore)."},{"issue":"9","key":"bib7-20240731","doi-asserted-by":"crossref","first-page":"3141","DOI":"10.1016\/j.arth.2021.04.033","article-title":"2-Octyl cyanoacrylate topical adhesive as an alternative to subcuticular suture for skin closure after total knee arthroplasty: a randomized controlled trial in the same patient","volume":"36","author":"Choi","year":"2021","journal-title":"J Arthroplasty."},{"issue":"10","key":"bib8-20240731","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1016\/j.jse.2022.04.014","article-title":"Comparing Dermabond PRINEO versus Dermabond or staples for wound closure: a randomized control trial following total shoulder arthroplasty","volume":"31","author":"Eichinger","year":"2022","journal-title":"J Shoulder Elbow Surg."},{"issue":"1","key":"bib9-20240731","doi-asserted-by":"crossref","first-page":"e0306","DOI":"10.2106\/JBJS.CC.18.00306","article-title":"Severe wound complication due to Prineo surgical dressing in shoulder hemiarthroplasty: a case report","volume":"10","author":"Pate","year":"2020","journal-title":"JBJS Case Connect."},{"issue":"6","key":"bib10-20240731","doi-asserted-by":"crossref","first-page":"e515","DOI":"10.3928\/01477447-20200827-01","article-title":"Allergic contact dermatitis to Dermabond Prineo after elective orthopedic surgery","volume":"43","author":"Ricciardo","year":"2020","journal-title":"Orthopedics."},{"key":"bib11-20240731","doi-asserted-by":"crossref","first-page":"642595","DOI":"10.1155\/2015\/642595","article-title":"Rash with DERMABOND PRINEO skin closure system use in bilateral reduction mammoplasty: a case series","volume":"2015","author":"Knackstedt","year":"2015","journal-title":"Case Rep Med."},{"issue":"3","key":"bib12-20240731","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1177\/22925503211015448","article-title":"Type IV hypersensitivity reaction to dermabond (2-octyl cyanoacrylate) in plastic surgical patients: a retrospective study","volume":"30","author":"Alotaibi","year":"2022","journal-title":"Plast Surg (Oakv)."},{"issue":"2","key":"bib13-20240731","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1097\/DER.0000000000000163","article-title":"Severe allergic contact dermatitis to Dermabond Prineo, a topical skin adhesive of 2-octyl cyanoacrylate increasingly used in surgeries to close wounds","volume":"27","author":"Davis","year":"2016","journal-title":"Dermatitis."},{"issue":"1","key":"bib14-20240731","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1097\/DER.0b013e31823d1b81","article-title":"Acrylates in contact dermatitis","volume":"23","author":"Sasseville","year":"2012","journal-title":"Dermatitis."},{"issue":"1 suppl","key":"bib15-20240731","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.1016\/j.amjmed.2013.09.008","article-title":"Recognition and first-line treatment of anaphylaxis","volume":"127","author":"Lieberman","year":"2014","journal-title":"Am J Med."}],"container-title":["JBJS Case Connector"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.2106\/JBJS.CC.22.00668","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T13:42:31Z","timestamp":1787751751000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.2106\/JBJS.CC.22.00668"}},"subtitle":["A Case Report"],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":15,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.2106\/jbjs.cc.22.00668","relation":{},"ISSN":["2160-3251"],"issn-type":[{"value":"2160-3251","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1]]}}}