{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:44:25Z","timestamp":1787755465857,"version":"build-2784847793"},"reference-count":5,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:p>\n                    Case: A 64-year-old male patient sustained a fracture of the humeral diaphysis on falling from a bicycle. During surgery, pus drainage from the intramedullary canal indicated infection, and cultures were positive for pansensitive\n                    <jats:italic toggle=\"yes\">Clostridium perfringens<\/jats:italic>\n                    . After initial stabilization, imaging showed inadequate fragment contact, leading to referral to our bone infection unit. A revision surgery with plate osteosynthesis was performed. Intravenous and oral antibiotic therapy was administered. Oral antibiotics were continued until 12 weeks postoperatively. At the 26-month follow-up, the patient presented with a good functional outcome.\n                  <\/jats:p>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      Fracture-related infections (FRI) pose serious complications, requiring swift surgical intervention. Although\n                      <jats:italic toggle=\"yes\">C. perfringens<\/jats:italic>\n                      infections in FRIs are rare and literature is scarce, this case highlights the successful management and good functional outcome, offering valuable insights for clinicians dealing with such infections.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.2106\/jbjs.cc.23.00497","type":"journal-article","created":{"date-parts":[[2024,5,18]],"date-time":"2024-05-18T01:47:52Z","timestamp":1715996872000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["An Upper-Arm Clostridium perfringens Fracture-Related Infection"],"prefix":"10.2106","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-7817-8140","authenticated-orcid":false,"given":"An\u017ee","family":"Lamut","sequence":"first","affiliation":[{"name":"Valdoltra Orthopaedic Hospital, Ankaran, Slovenia"},{"name":"Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samo","family":"Ro\u0161kar","sequence":"additional","affiliation":[{"name":"Valdoltra Orthopaedic Hospital, Ankaran, Slovenia"},{"name":"Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rene","family":"Mihali\u010d","sequence":"additional","affiliation":[{"name":"Valdoltra Orthopaedic Hospital, Ankaran, Slovenia"},{"name":"Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rihard","family":"Treb\u0161e","sequence":"additional","affiliation":[{"name":"Valdoltra Orthopaedic Hospital, Ankaran, Slovenia"},{"name":"Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,4]]},"reference":[{"issue":"10","key":"bib1-20240805","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1302\/2058-5241.5.190072","article-title":"Definition and diagnosis of fracture-related infection","volume":"5","author":"McNally","year":"2020","journal-title":"EFORT Open Rev."},{"issue":"1","key":"bib2-20240805","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1080\/21505594.2021.1886777","article-title":"Pathogenicity and virulence of Clostridium perfringens","volume":"12","author":"Mehdizadeh Gohari","year":"2021","journal-title":"Virulence."},{"issue":"1","key":"bib3-20240805","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.idc.2020.10.004","article-title":"Necrotizing soft tissue infections","volume":"35","author":"Stevens","year":"2021","journal-title":"Infect Dis Clin North Am."},{"issue":"6","key":"bib4-20240805","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.otsr.2012.03.019","article-title":"Post-traumatic bone and\/or joint limb infections due to Clostridium spp","volume":"98","author":"Ibnoulkhatib","year":"2012","journal-title":"Orthop Traumatol Surg Res."},{"issue":"8","key":"bib5-20240805","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1007\/s00402-019-03287-4","article-title":"General treatment principles for fracture-related infection: recommendations from an international expert group","volume":"140","author":"Metsemakers","year":"2020","journal-title":"Arch Orthop Trauma Surg."}],"container-title":["JBJS Case Connector"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.2106\/JBJS.CC.23.00497","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T13:43:13Z","timestamp":1787751793000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.2106\/JBJS.CC.23.00497"}},"subtitle":["A Case Report"],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":5,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.2106\/jbjs.cc.23.00497","relation":{},"ISSN":["2160-3251"],"issn-type":[{"value":"2160-3251","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4]]}}}