{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:44:05Z","timestamp":1787755445134,"version":"build-2784847793"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec>\n                    <jats:title>Case:<\/jats:title>\n                    <jats:p>A 79-year-old woman presented with a periprosthetic fracture 8 years after a total knee arthroplasty (TKA). Radiographs demonstrated tibial implant loosening with severe osteolysis. A high-grade osteosarcoma around the prosthesis was diagnosed, and a supracondylar femoral amputation was performed. After 2 years, no complications have occurred.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>A malignant tumor around a TKA is extremely rare. Surgeons should remain vigilant with patients who present with rapidly progressive or very aggressive implant loosening with osteolysis. Owing to its complexity and potentially devastating prognosis, treatment should be guided by a specialist multidisciplinary team. Complex limb salvage procedures or amputation is usually required.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2106\/jbjs.cc.23.00633","type":"journal-article","created":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T14:06:37Z","timestamp":1715349997000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Osteosarcoma After Total Knee Arthroplasty"],"prefix":"10.2106","volume":"14","author":[{"given":"Pablo","family":"Mart\u00ednez-Collado","sequence":"first","affiliation":[{"name":"Orthopedic Surgery Department, Vall d'Hebron University Hospital, Universitat Aut\u00f3noma de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4760-2730","authenticated-orcid":false,"given":"Oriol","family":"Pujol","sequence":"additional","affiliation":[{"name":"Knee Surgery Unit, Orthopedic Surgery Department, Vall d'Hebron University Hospital, Universitat Aut\u00f3noma de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9s","family":"Bustos","sequence":"additional","affiliation":[{"name":"Orthopedic Surgery Department, Vall d'Hebron University Hospital, Universitat Aut\u00f3noma de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mart\u00ed","family":"Plomer","sequence":"additional","affiliation":[{"name":"Knee Surgery Unit, Orthopedic Surgery Department, Vall d'Hebron University Hospital, Universitat Aut\u00f3noma de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda G.","family":"Carrasco","sequence":"additional","affiliation":[{"name":"Orthopedic Oncologic Unit, Orthopedic Surgery Department, Vall d'Hebron University Hospital, Universitat Aut\u00f3noma de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tulio","family":"Silva","sequence":"additional","affiliation":[{"name":"Anatomopathological Department, Vall d'Hebron University Hospital, Universitat Aut\u00f3noma de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"V\u00e9lez","sequence":"additional","affiliation":[{"name":"Orthopedic Oncologic Unit, Orthopedic Surgery Department, Vall d'Hebron University Hospital, Universitat Aut\u00f3noma de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Minguell","sequence":"additional","affiliation":[{"name":"Knee Surgery Unit, Orthopedic Surgery Department, Vall d'Hebron University Hospital, Universitat Aut\u00f3noma de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,4]]},"reference":[{"issue":"8","key":"bib1-20240805","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.3390\/jcm12082785","article-title":"Osteosarcoma: current concepts and evolutions in management principles","volume":"12","author":"Pilavaki","year":"2023","journal-title":"J Clin Med."},{"issue":"4","key":"bib2-20240805","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1007\/s11914-023-00803-9","article-title":"Advances in osteosarcoma","volume":"21","author":"Panez-Toro","year":"2023","journal-title":"Curr Osteoporos Rep."},{"key":"bib3-20240805","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.knee.2020.11.019","article-title":"Angiosarcoma after revision total knee arthroplasty","volume":"28","author":"Fukuda","year":"2021","journal-title":"Knee."},{"key":"bib4-20240805","first-page":"324","article-title":"Malignant fibrous 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87,683 controls","volume":"93","author":"Hailer","year":"2022","journal-title":"Acta Orthop."},{"issue":"1","key":"bib11-20240805","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1002\/ijc.32711","article-title":"No generally increased risk of cancer after total hip arthroplasty performed due to osteoarthritis","volume":"147","author":"Hailer","year":"2020","journal-title":"Int J Cancer."},{"issue":"3","key":"bib12-20240805","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1302\/0301-620X.104B3.BJJ-2021-0397.R1","article-title":"The risk of all-cause mortality, heart outcomes, cancer, and neurodegenerative disorders with cobalt-chrome-containing total hip arthroplasty implants: an analysis of the National Joint Registry","volume":"104-B","author":"Deere","year":"2022","journal-title":"Bone Joint J."}],"container-title":["JBJS Case 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