{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T15:07:20Z","timestamp":1788793640696,"version":"build-2803163510"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","funder":[{"name":"NIH\/NCI","award":["P30 CA008748"],"award-info":[{"award-number":["P30 CA008748"]}]}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec>\n                    <jats:title>Case:<\/jats:title>\n                    <jats:p>We present 2 cases of severe hemodynamic collapse during prophylactic stabilization of impending pathologic humerus fractures using a photodynamic bone stabilization device. Both events occurred when the monomer was infused under pressure into a balloon catheter.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>We suspect that an increase in intramedullary pressure during balloon expansion may cause adverse systemic effects similar to fat embolism or bone cement implantation syndrome. Appropriate communication with the anesthesia team, invasive hemodynamic monitoring, and prophylactic vent hole creation may help mitigate or manage these adverse systemic effects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2106\/jbjs.cc.23.00634","type":"journal-article","created":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T14:04:50Z","timestamp":1713449090000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Severe Hemodynamic Collapse During Humerus Stabilization with Photodynamic Implant"],"prefix":"10.2106","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3250-6615","authenticated-orcid":false,"given":"Samir","family":"Sabharwal","sequence":"first","affiliation":[{"name":"Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8201-5091","authenticated-orcid":false,"given":"Patrick J.","family":"Boland","sequence":"additional","affiliation":[{"name":"Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7364-3259","authenticated-orcid":false,"given":"Max","family":"Vaynrub","sequence":"additional","affiliation":[{"name":"Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,4]]},"reference":[{"issue":"4 Suppl 2","key":"bib1-20240805","doi-asserted-by":"crossref","first-page":"e27","DOI":"10.1016\/j.jamcollsurg.2016.08.073","article-title":"Lightfix: a prospective, multi-center study of the photodynamic bone stabilization system for the treatment of impending and actual pathological fractures from metastatic bone disease in the humerus","volume":"223","author":"Golub","year":"2016","journal-title":"J Am Coll Surgeons."},{"issue":"4","key":"bib2-20240805","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.injury.2020.02.124","article-title":"Evaluating the reoperation rate and hardware durability of three stabilizing implants for 105 malignant pathologic humerus fractures","volume":"51","author":"Hoellwarth","year":"2020","journal-title":"Injury."},{"issue":"9","key":"bib3-20240805","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1097\/COC.0000000000000937","article-title":"Intramedullary nailing versus compound plate osteosynthesis in pathologic diaphyseal humerus fractures: a retrospective cohort study","volume":"45","author":"Koob","year":"2022","journal-title":"Am J Clin 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The role of intramedullary pressure","volume":"69","author":"Orsini","year":"1987","journal-title":"J Bone Joint Surg Am."},{"issue":"5","key":"bib12-20240805","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1097\/00005373-199705000-00028","article-title":"Intramedullary pressure and bone marrow fat intravasation in unreamed femoral nailing","volume":"42","author":"Kr\u00f6pfl","year":"1997","journal-title":"J Trauma."},{"issue":"2","key":"bib13-20240805","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/BF03012996","article-title":"Cement implantation syndrome: a time limited embolic phenomenon","volume":"44","author":"Byrick","year":"1997","journal-title":"Can J Anaesth."},{"issue":"2","key":"bib14-20240805","doi-asserted-by":"crossref","first-page":"271","DOI":"10.2106\/00004623-199173020-00015","article-title":"Cardiac arrest during hip arthroplasty with a cemented long-stem component. 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