{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:43:20Z","timestamp":1787755400717,"version":"build-2784847793"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec>\n                    <jats:title>Case:<\/jats:title>\n                    <jats:p>A 43-year-old healthy man developed hip pain post\u2013coronavirus disease 2019 (COVID-19) immobilization. Imaging confirmed bilateral bridging heterotopic ossification (HO) of the hips, Brooker Class IV. Bilateral HO caused functional arthrodesis (45\u00b0 flexion: \u221220\u00b0 internal rotation). Bilateral HO resection resulted in almost full mobility at 1-year follow-up (90\u00b0 flexion; 30\u00b0 internal rotation).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Many cases of HO after immobilization for COVID-19 have been reported, but as far as we know, this is the first case report describing surgical intervention as an adequate treatment option for severe restricted mobility caused by HO due to COVID-19\u2013induced prolonged immobilization. Caution and preoperative 3D planning are recommended of HO formation near neurovascular structures.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2106\/jbjs.cc.23.00761","type":"journal-article","created":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T14:03:29Z","timestamp":1710425009000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Heterotopic Ossification of Bilateral Hips Post\u2013COVID-19 and Prolonged Immobilization"],"prefix":"10.2106","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2189-646X","authenticated-orcid":false,"given":"Olaf N.","family":"van de Langerijt","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, Cura\u00e7ao Medical Center, Willemstad, Cura\u00e7ao"},{"name":"Department of Orthopaedic Surgery, University Medical Center Utrecht, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5091-3110","authenticated-orcid":false,"given":"Olivier Q.","family":"Groot","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Cura\u00e7ao Medical Center, Willemstad, Cura\u00e7ao"},{"name":"Department of Orthopaedic Surgery, University Medical Center Utrecht, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3099-8831","authenticated-orcid":false,"given":"Michiel M.A.","family":"Janssen","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Cura\u00e7ao Medical Center, Willemstad, Cura\u00e7ao"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,1]]},"reference":[{"issue":"4","key":"bib1-20240805","doi-asserted-by":"crossref","first-page":"e10172","DOI":"10.1002\/jbm4.10172","article-title":"Heterotopic ossification: a comprehensive review","volume":"3","author":"Meyers","year":"2019","journal-title":"JBMR Plus."},{"issue":"7","key":"bib2-20240805","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/j.cmi.2020.12.037","article-title":"High prevalence of heterotopic ossification in critically ill patients with severe COVID-19","volume":"27","author":"Stoira","year":"2021","journal-title":"Clin Microbiol Infect."},{"issue":"6","key":"bib3-20240805","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.rehab.2020.09.010","article-title":"Heterotopic ossification in COVID-19: a series of 4 cases","volume":"63","author":"Meyer","year":"2020","journal-title":"Ann Phys Rehabil Med."},{"issue":"2","key":"bib4-20240805","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.radcr.2020.12.002","article-title":"Heterotopic ossification post COVID-19: report of two cases","volume":"16","author":"Aziz","year":"2021","journal-title":"Radiol case Rep."},{"issue":"1","key":"bib5-20240805","doi-asserted-by":"crossref","first-page":"149","DOI":"10.5606\/tftrd.2022.8172","article-title":"A case report of a patient with COVID-19 infection and widespread heterotopic ossification","volume":"68","author":"Vardar","year":"2022","journal-title":"Turkish J Phys Med Rehabil."},{"issue":"3","key":"bib6-20240805","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1093\/omcr\/omac024","article-title":"Bilateral intercostal, subscapular and teres major heterotopic ossifications in a 63-year-old male with COVID-19","volume":"2022","author":"Micolich Vergara","year":"2022","journal-title":"Oxford Med Case Rep."},{"key":"bib7-20240805","doi-asserted-by":"crossref","first-page":"116287","DOI":"10.1016\/j.bone.2021.116287","article-title":"Extensive progressive heterotopic ossification post-Covid-19 in a man","volume":"155","author":"Brance","year":"2022","journal-title":"Bone."},{"issue":"4","key":"bib8-20240805","doi-asserted-by":"crossref","first-page":"550","DOI":"10.3390\/traumacare2040045","article-title":"Heterotopic ossification after a prolonged course of COVID-19: a case report and review of the literature","volume":"2","author":"Milner","year":"2022","journal-title":"Trauma Care."},{"issue":"7","key":"bib9-20240805","first-page":"31","article-title":"Long-term orthopedic manifestations of COVID-19: heterotopic ossification and digital necrosis","volume":"105","author":"Liu","year":"2022","journal-title":"R I Med J."},{"issue":"8","key":"bib10-20240805","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.2106\/00004623-197355080-00006","article-title":"Ectopic ossification following total hip replacement. Incidence and a method of classification","volume":"55","author":"Brooker","year":"1973","journal-title":"J Bone Joint Surg Am."},{"issue":"3","key":"bib11-20240805","first-page":"346","article-title":"Heterotopic ossification","volume":"43","author":"Shehab","year":"2002","journal-title":"J Nucl Med."},{"key":"bib12-20240805","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1471-2474-4-10","article-title":"Hip disability and osteoarthritis outcome score (HOOS)\u2014validity and responsiveness in total hip replacement","volume":"4","author":"Nilsdotter","year":"2003","journal-title":"BMC Musculoskelet Disord."},{"issue":"8","key":"bib15-20240805","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1007\/BF00204862","article-title":"Periarticular heterotopic ossification following pharmacologically induced paralysis","volume":"24","author":"Ray","year":"1995","journal-title":"Skeletal Radiol."},{"issue":"7","key":"bib16-20240805","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1093\/rheumatology\/35.7.700","article-title":"Heterotopic ossification complicating long-term sedation","volume":"35","author":"Dellestable","year":"1996","journal-title":"Br J Rheumatol."},{"issue":"9","key":"bib17-20240805","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1002\/art.1780400911","article-title":"Heterotopic ossification in the setting of neuromuscular blockade","volume":"40","author":"Goodman","year":"1997","journal-title":"Arthritis Rheum."},{"issue":"2","key":"bib18-20240805","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S1058-2746(99)90015-0","article-title":"Surgical management of heterotopic ossification of the shoulder","volume":"8","author":"Warner","year":"1999","journal-title":"J Shoulder Elbow Surg."},{"issue":"11","key":"bib19-20240805","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1093\/rheumatology\/38.11.1145","article-title":"Polyarticular heterotopic ossification complicating critical illness","volume":"38","author":"Jacobs","year":"1999","journal-title":"Rheumatology."},{"issue":"1","key":"bib20-20240805","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1080\/10790268.2002.11754547","article-title":"Heterotopic ossification complicating prolonged intubation: case report and review of the literature","volume":"25","author":"Hewitt","year":"2002","journal-title":"J Spinal Cord Med."},{"issue":"2","key":"bib21-20240805","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/PL00011219","article-title":"Polyarticular heterotopic ossification complicating drug-induced coma","volume":"21","author":"Sebastiani","year":"2002","journal-title":"Clin Rheumatol."},{"issue":"6","key":"bib22-20240805","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1053\/apmr.2002.32440","article-title":"Heterotopic ossification in critical illness and cancer: a report of 2 cases","volume":"83","author":"Guo","year":"2002","journal-title":"Arch Phys Med Rehabil."},{"issue":"4","key":"bib23-20240805","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s00774-005-0608-5","article-title":"Heterotopic ossification in bilateral knee and hip joints after long-term sedation","volume":"23","author":"Sugita","year":"2005","journal-title":"J Bone Miner Metab."},{"issue":"4","key":"bib24-20240805","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1111\/os.12009","article-title":"Atraumatic heterotopic ossification in the setting of prolonged intubation because of H1N1 Influenza: a case report","volume":"4","author":"Davis","year":"2012","journal-title":"Orthop Surg."},{"issue":"1","key":"bib25-20240805","first-page":"118","article-title":"Two cases of myositis ossificans in children, after prolonged immobilization","volume":"19","author":"Kougias","year":"2019","journal-title":"J Musculoskelet Neuronal Interact."},{"issue":"5","key":"bib26-20240805","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1378\/chest.104.5.1526","article-title":"Heterotopic ossification complicating critical illness","volume":"104","author":"Clements","year":"1993","journal-title":"Chest."},{"issue":"5","key":"bib27-20240805","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/BF00197078","article-title":"Generalized periarticular myositis ossificans as a complication of pharmacologically induced paralysis","volume":"24","author":"Ackman","year":"1995","journal-title":"Skeletal Radiol."},{"issue":"8","key":"bib28-20240805","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1056\/NEJMoa022450","article-title":"One-year outcomes in survivors of the acute respiratory distress syndrome","volume":"348","author":"Herridge","year":"2003","journal-title":"N Engl J Med."},{"issue":"2","key":"bib30-20240805","doi-asserted-by":"crossref","first-page":"151","DOI":"10.3233\/NRE-2011-0643","article-title":"A comparison of heterotopic ossification treatment within the traumatic brain and spinal cord injured population: an evidence based systematic review","volume":"28","author":"Aubut","year":"2011","journal-title":"NeuroRehabilitation."}],"container-title":["JBJS Case Connector"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.2106\/JBJS.CC.23.00761","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T13:42:27Z","timestamp":1787751747000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.2106\/JBJS.CC.23.00761"}},"subtitle":["A Case Report"],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":27,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.2106\/jbjs.cc.23.00761","relation":{},"ISSN":["2160-3251"],"issn-type":[{"value":"2160-3251","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1]]}}}