{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:45:42Z","timestamp":1787755542474,"version":"build-2784847793"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec>\n                    <jats:title>Case:<\/jats:title>\n                    <jats:p>A 30-year-old man with a history of advanced HIV disease (AHD) presented with bilateral equinocavus, leg, and foot muscle paresis, Brooker grade 4 heterotopic ossification of hips and knee stiffness, and was unable to sit upright, stand independently, or walk. Electromyography showed demyelinating sensorimotor and axonal polyneuropathy of lower extremities. Multiple surgeries of bilateral hips, ankles, and feet enabled joint mobility, plantigrade feet, and independent ambulation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Patients with AHD may develop multijoint pathologies, secondary to HIV, antiretroviral therapy, or prolonged immobility, resulting in loss of ambulation and independence. Restoring ambulation may necessitate multiple surgeries, with potential for success.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2106\/jbjs.cc.24.00025","type":"journal-article","created":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T14:27:56Z","timestamp":1726237676000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Immobile to Ambulation: Complex Multijoint Pathologies in a Patient with Advanced HIV Disease"],"prefix":"10.2106","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6170-5220","authenticated-orcid":false,"given":"Justin T.","family":"Samuel","sequence":"first","affiliation":[{"name":"CUNY School of Medicine, New York, New York"},{"name":"Department of Orthopedic Surgery, St. Barnabas Hospital, Bronx, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0539-4144","authenticated-orcid":false,"given":"Imani N.","family":"Nwokeji","sequence":"additional","affiliation":[{"name":"CUNY School of Medicine, New York, New York"},{"name":"Department of Orthopedic Surgery, St. Barnabas Hospital, Bronx, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7153-4885","authenticated-orcid":false,"given":"Sehrish","family":"Ali","sequence":"additional","affiliation":[{"name":"CUNY School of Medicine, New York, New York"},{"name":"Department of Orthopedic Surgery, St. Barnabas Hospital, Bronx, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0573-4395","authenticated-orcid":false,"given":"Nityananda Rao","family":"Jakkula","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, St. Barnabas Hospital, Bronx, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4762-2176","authenticated-orcid":false,"given":"Jonathan","family":"Fung","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, St. Barnabas Hospital, Bronx, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7257-9409","authenticated-orcid":false,"given":"Andrew","family":"Campbell","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, St. Barnabas Hospital, Bronx, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4567-6915","authenticated-orcid":false,"given":"Naveen","family":"Singanamala","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, St. Barnabas Hospital, Bronx, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,7]]},"reference":[{"issue":"8","key":"bib1-20240913","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1111\/hiv.13487","article-title":"Advanced HIV disease: a review of diagnostic and prophylactic strategies","volume":"24","author":"Lehman","year":"2023","journal-title":"HIV Med."},{"issue":"1","key":"bib2-20240913","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s11596-022-2524-5","article-title":"Musculoskeletal conditions in persons living with HIV\/AIDS: a scoping review","volume":"42","author":"Berg","year":"2022","journal-title":"Curr Med Sci."},{"issue":"5","key":"bib3-20240913","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s00256-004-0764-z","article-title":"Musculoskeletal disorders associated with HIV infection and AIDS. Part I: infectious musculoskeletal conditions","volume":"33","author":"Tehranzadeh","year":"2004","journal-title":"Skeletal Radiol."},{"key":"bib4-20240913","first-page":"773","article-title":"An operation for the correction of extremely relaxed flatfeet","volume":"13","author":"Hoke","year":"1931","journal-title":"J Bone Joint Surg."},{"issue":"7","key":"bib5-20240913","doi-asserted-by":"crossref","first-page":"e94","DOI":"10.1097\/PHM.0000000000001629","article-title":"HIV neuropathy-associated foot drop, a presenting sign of HIV infection, resolving after initiation of antiretroviral therapy: a clinical vignette","volume":"100","author":"Mohan","year":"2021","journal-title":"Am J Phys Med Rehabil."},{"issue":"2","key":"bib6-20240913","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1007\/s11914-015-0258-z","article-title":"The immunological contribution to heterotopic ossification disorders","volume":"13","author":"Convente","year":"2015","journal-title":"Curr Osteoporos Rep."},{"issue":"6","key":"bib7-20240913","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1186\/cc5091","article-title":"Heterotopic ossification--a long-term consequence of prolonged immobility","volume":"10","author":"Hudson","year":"2006","journal-title":"Crit Care."},{"issue":"1","key":"bib8-20240913","first-page":"14","article-title":"Hip and knee replacement in the HIV positive patient","volume":"24","author":"Anand","year":"2012","journal-title":"Malawi Med J."},{"issue":"3","key":"bib9-20240913","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1302\/0301-620X.91B3.21706","article-title":"Joint replacement in Malawi: establishment of a National joint registry","volume":"91","author":"Lubega","year":"2009","journal-title":"J Bone Joint Surg Br."},{"issue":"supp III","key":"bib10-20240913","first-page":"473","article-title":"Arthroplasty in HIV infected patients \u2013 a 5 Year follow up","volume":"90-B","author":"Brijlall","year":"2008","journal-title":"Orthopaedic Proc."},{"issue":"9","key":"bib11-20240913","doi-asserted-by":"crossref","first-page":"777","DOI":"10.2106\/JBJS.16.01435","article-title":"Development and evaluation of a preoperative risk calculator for periprosthetic joint infection following total joint arthroplasty","volume":"100","author":"Tan","year":"2018","journal-title":"J Bone Jt Surg Am."},{"issue":"9","key":"bib12-20240913","doi-asserted-by":"crossref","first-page":"775","DOI":"10.2106\/JBJS.15.00842","article-title":"HIV and orthopaedics: musculoskeletal manifestations and outcomes","volume":"98","author":"Pretell-Mazzini","year":"2016","journal-title":"J Bone Joint Surg Am."},{"issue":"4","key":"bib13-20240913","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1177\/1071100714523270","article-title":"Surgical correction of severe deformity of the ankle and hindfoot by arthrodesis using a compressing retrograde intramedullary nail","volume":"35","author":"Brodsky","year":"2014","journal-title":"Foot Ankle Int."},{"issue":"3","key":"bib14-20240913","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s12178-018-9507-y","article-title":"Retrograde hindfoot nailing for acute trauma","volume":"11","author":"Tarkin","year":"2018","journal-title":"Curr Rev Musculoskelet Med."},{"issue":"3","key":"bib15-20240913","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1302\/0301-620X.102B3.BJJ-2019-1325.R1","article-title":"Factors affecting the outcomes of tibiotalocalcaneal fusion","volume":"102-B","author":"Pitts","year":"2020","journal-title":"Bone Joint J."}],"container-title":["JBJS Case Connector"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.2106\/JBJS.CC.24.00025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T13:44:03Z","timestamp":1787751843000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.2106\/JBJS.CC.24.00025"}},"subtitle":["A Case Report"],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":15,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.2106\/jbjs.cc.24.00025","relation":{},"ISSN":["2160-3251"],"issn-type":[{"value":"2160-3251","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7]]}}}