{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:17:41Z","timestamp":1787753861131,"version":"build-2784847793"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec>\n                    <jats:title>Case:<\/jats:title>\n                    <jats:p>\n                      A 35-year-old man presented with low backache and bilateral hip pain for 3 years. On evaluation, he had elevated alkaline phosphatase (391.3 U\/L) and low phosphorus (2.01 mg\/dL). Imaging showed bilateral femoral neck insufficiency fractures, and\n                      <jats:sup>68<\/jats:sup>\n                      Ga-DOTANOC-PET-CT scan revealed a tumor in the femoral head. En bloc tumor excision with femoral head preservation under CT navigation was performed. Histopathology confirmed a phosphaturic mesenchymal tumor. Phosphorus normalized at the first-week review, and symptoms improved without supplements.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Tumor-induced osteomalacia should be kept as a differential diagnosis in patients with generalized weakness and hypophosphatemia, and wide-margin excision results in permanent cure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2106\/jbjs.cc.24.00107","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T18:00:19Z","timestamp":1775844019000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Oncogenic Osteomalacia Due to Tumor in the Femoral Head Managed by Excision and Femoral Head Preservation"],"prefix":"10.2106","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6043-006X","authenticated-orcid":false,"given":"Shanmuganathan","family":"Rajasekaran","sequence":"first","affiliation":[{"name":"Department of Orthopaedics, Ganga Hospital, Coimbatore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhanasekaran","family":"Soundarrajan","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Ganga Hospital, Coimbatore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rithika","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Ganga Hospital, Coimbatore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0378-7411","authenticated-orcid":false,"given":"Raja Bhaskara","family":"Rajasekaran","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Ganga Hospital, Coimbatore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,4]]},"reference":[{"issue":"3","key":"bib1-20260410","doi-asserted-by":"crossref","first-page":"R53","DOI":"10.1530\/ERC-11-0006","article-title":"Tumor-induced osteomalacia","volume":"18","author":"Chong","year":"2011","journal-title":"Endocrine-Related Cancer."},{"issue":"4","key":"bib2-20260410","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.afos.2018.12.001","article-title":"Tumor-induced osteomalacia","volume":"4","author":"Yin","year":"2018","journal-title":"Osteoporos Sarcopenia."},{"key":"bib3-20260410","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s12957-015-0763-7","article-title":"Tumour-induced osteomalacia: a literature review and a case report","volume":"14","author":"Dadoniene","year":"2015","journal-title":"World J Surg Oncol."},{"issue":"1","key":"bib4-20260410","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1210\/jcem-67-1-46","article-title":"Hemangiopericytoma-induced osteomalacia: tumor transplantation in nude mice causes hypophosphatemia and tumor extracts inhibit renal 25-hydroxyvitamin D 1-hydroxylase activity","volume":"67","author":"Miyauchi","year":"1988","journal-title":"J Clin Endocrinol Metab."},{"issue":"4","key":"bib5-20260410","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1056\/NEJMc070347","article-title":"Radiofrequency ablation of a tumor causing oncogenic osteomalacia","volume":"357","author":"Hesse","year":"2007","journal-title":"N Engl J Med."},{"issue":"7","key":"bib6-20260410","doi-asserted-by":"crossref","first-page":"2714","DOI":"10.3390\/jcm12072714","article-title":"Osteomalacia in adults: a practical insight for clinicians","volume":"12","author":"Arboleya","year":"2023","journal-title":"J Clin Med."},{"issue":"1","key":"bib7-20260410","first-page":"e10447","article-title":"Osteomalacia and vitamin D status: a clinical update 2020","volume":"5","author":"Minisola","year":"2021","journal-title":"J Bone Mineral Res Plus."},{"issue":"3","key":"bib8-20260410","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1210\/er.2005-0019","article-title":"The roles of specific genes implicated as circulating factors involved in normal and disordered phosphate homeostasis: frizzled-related protein-4, matrix extracellular phosphoglycoprotein, and fibroblast growth factor 23","volume":"27","author":"White","year":"2006","journal-title":"Endocr Rev."},{"issue":"4","key":"bib9-20260410","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s00223-022-01005-8","article-title":"Tumor-induced osteomalacia: a systematic clinical review of 895 cases","volume":"111","author":"Bosman","year":"2022","journal-title":"Calcified Tissue Int."},{"key":"bib10-20260410","doi-asserted-by":"crossref","first-page":"503956","DOI":"10.1155\/2012\/503956","article-title":"A case of acute prosthesis migration after femoral head replacement due to osteomalacia by FGF23-induced tumor","volume":"2012","author":"Hayashi","year":"2012","journal-title":"Case Rep Med."},{"issue":"3","key":"bib11-20260410","doi-asserted-by":"crossref","first-page":"137","DOI":"10.4158\/EP.3.3.137","article-title":"Reversible avascular necrosis of the femoral head in tumor-induced osteomalacia","volume":"3","author":"Sharkis","year":"1997","journal-title":"Endocr Pract."},{"issue":"2","key":"bib12-20260410","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s002560000306","article-title":"Recurrent malignant variant of phosphaturic mesenchymal tumor with oncogenic osteomalacia","volume":"30","author":"Ogose","year":"2001","journal-title":"Skeletal Radiol."},{"issue":"12","key":"bib13-20260410","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1093\/rheumatology\/39.12.1415","article-title":"Four cases of acquired hypophosphataemic (\u201concogenic\u201d) osteomalacia. Problems of diagnosis, treatment and long-term management","volume":"39","author":"Clunie","year":"2000","journal-title":"Rheumatology."},{"issue":"6","key":"bib14-20260410","doi-asserted-by":"crossref","first-page":"e32913","DOI":"10.1097\/MD.0000000000032913","article-title":"Femoral head cartilage reconstruction using autologous osteochondral mosaicplasty: a case report","volume":"102","author":"Lee","year":"2023","journal-title":"Medicine."},{"issue":"2","key":"bib15-20260410","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1308\/rcsann.2019.0004","article-title":"Current status of bone cementing and bone grafting for giant cell tumour of bone: a systemic review","volume":"101","author":"Vaishya","year":"2019","journal-title":"Ann R Coll Surg Engl."}],"container-title":["JBJS Case Connector"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.2106\/JBJS.CC.24.00107","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T13:20:05Z","timestamp":1787750405000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.2106\/JBJS.CC.24.00107"}},"subtitle":["A Case Report"],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":15,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.2106\/jbjs.cc.24.00107","relation":{},"ISSN":["2160-3251"],"issn-type":[{"value":"2160-3251","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]}}}