{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:44:45Z","timestamp":1787755485141,"version":"build-2784847793"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec>\n                    <jats:title>Case:<\/jats:title>\n                    <jats:p>A 38-year-old woman presented to our clinic with right knee pain and difficulty ambulating. After cultures were obtained, a cryptococcal infection of the patella was identified. Subsequent workup revealed previously undiagnosed HIV\/AIDS and a disseminated cryptococcal infection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Over a 20-month course, the patient was treated with fluconazole and antiretroviral therapy with very limited medication compliance. The disseminated infection caused cutaneous, hepatic, and cerebral complications. Eventually, compliance improved, and a final procedure to obtain post-treatment cultures and apply antifungal bone matrix was completed. The patient cleared the infection and will likely require lifetime antifungal treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2106\/jbjs.cc.24.00304","type":"journal-article","created":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T19:09:12Z","timestamp":1724958552000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Cryptococcal Osteomyelitis of the Patella"],"prefix":"10.2106","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2047-2462","authenticated-orcid":false,"given":"Jacob","family":"Harper","sequence":"first","affiliation":[{"name":"John Sealy School of Medicine, The University of Texas Medical Branch, Galveston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9751-4662","authenticated-orcid":false,"given":"Paul J.","family":"Weatherby","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery and Rehabilitation, The University of Texas Medical Branch, Galveston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Foreman","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery and Rehabilitation, The University of Texas Medical Branch, Galveston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,7]]},"reference":[{"issue":"1","key":"bib1-20240829","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.idc.2015.10.006","article-title":"Cryptococcosis","volume":"30","author":"Maziarz","year":"2016","journal-title":"Infect Dis Clin North Am."},{"issue":"3","key":"bib3-20240829","first-page":"227","article-title":"Saprophytic sources of Cryptococcus neoformans associated with the pigeon (Columba livia)","volume":"62","author":"Emmons","year":"1955","journal-title":"Am J Hyg."},{"issue":"26","key":"bib4-20240829","doi-asserted-by":"crossref","first-page":"15245","DOI":"10.1073\/pnas.261418798","article-title":"Cryptococcus neoformans interactions with amoebae suggest an explanation for its virulence and intracellular pathogenic strategy in macrophages","volume":"98","author":"Steenbergen","year":"2001","journal-title":"Proc Natl Acad Sci U S A."},{"key":"bib5-20240829","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/bs.adgen.2020.02.001","article-title":"Pathogen and host genetics underpinning cryptococcal disease","volume":"105","author":"Coelho","year":"2020","journal-title":"Adv Genet."},{"issue":"5","key":"bib6-20240829","doi-asserted-by":"crossref","first-page":"656","DOI":"10.4067\/S0716-10182019000500656","article-title":"Criptococosis vertebral. 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