{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:29:40Z","timestamp":1787754580515,"version":"build-2784847793"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec>\n                    <jats:title>Case:<\/jats:title>\n                    <jats:p>Gorham-Stout disease (GSD) is a rare disorder marked by massive bone destruction. A 56-year-old woman with GSD presented to our hospital with a proximal femur fracture. She was initially diagnosed with a simple fracture and underwent open reduction and internal fixation using an intramedullary nail. However, the delayed diagnosis of GSD resulted in postponed appropriate treatment. Although the intramedullary nail helped prevent mechanical bone failure, extensive osteolysis continued, ultimately necessitating total femur replacement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This case highlights the importance of considering GSD as a potential diagnosis of extensive osteolysis to avoid delays in treatment and subsequent severe bone loss.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2106\/jbjs.cc.25.00075","type":"journal-article","created":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T18:02:04Z","timestamp":1752170524000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Massive Osteolysis of the Femur (Gorham-Stout Disease) Requiring Total Femur Replacement"],"prefix":"10.2106","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-4306-8592","authenticated-orcid":false,"given":"Sho","family":"Masuda","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan"},{"name":"Department of Orthopaedic Surgery, Osaka Saiseikai Nakatsu HospitalOsaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2938-6149","authenticated-orcid":false,"given":"Hirotsugu","family":"Ohashi","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Osaka Saiseikai Nakatsu HospitalOsaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1939-8288","authenticated-orcid":false,"given":"Yukihide","family":"Minoda","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3750-9633","authenticated-orcid":false,"given":"Makoto","family":"Ieguchi","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Izumiotsu Medical Center, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8747-7279","authenticated-orcid":false,"given":"Kentaro","family":"Inui","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Osaka Saiseikai Nakatsu HospitalOsaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9183-3363","authenticated-orcid":false,"given":"Hidetomi","family":"Terai","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,7]]},"reference":[{"issue":"1","key":"bib1-20250710","doi-asserted-by":"crossref","first-page":"e20","DOI":"10.2106\/JBJS.CC.20.00296","article-title":"Gorham-Stout disease resulting in spinal deformity treated by fusion surgery combined with everolimus therapy: a case report","volume":"11","author":"Toga","year":"2021","journal-title":"JBJS Case Connector."},{"key":"bib2-20250710","first-page":"368","article-title":"A singular case of absorption of bone (a boneless arm)","volume":"18","author":"Jackson","year":"1838","journal-title":"Boston Med Surg J."},{"issue":"5","key":"bib3-20250710","doi-asserted-by":"crossref","first-page":"985","DOI":"10.2106\/00004623-195537050-00008","article-title":"Massive osteolysis (acute spontaneous absorption of bone, phantom bone, disappearing bone); 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