{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:45:57Z","timestamp":1787755557381,"version":"build-2784847793"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec>\n                    <jats:title>Case:<\/jats:title>\n                    <jats:p>A 74-year-old woman with chronic myeloid leukemia on long-term imatinib therapy and a history of bisphosphonate use presented with an atypical femoral fracture after low-energy trauma. She underwent staged intramedullary nailing of both femurs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This case highlights the potential synergistic effect of bisphosphonates and imatinib on bone metabolism, leading to an increased risk of atypical femoral fractures. Vigilant monitoring of bone health in such patients is crucial for early detection and prevention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2106\/jbjs.cc.25.00106","type":"journal-article","created":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T14:00:36Z","timestamp":1747404036000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Atypical Femoral Fracture in a Patient on Imatinib"],"prefix":"10.2106","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3536-9145","authenticated-orcid":false,"given":"Amirzeb","family":"Aurangzeb","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, Changi General Hospital, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kinjal Vidyut","family":"Mehta","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Changi General Hospital, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siti Mastura","family":"Binte Rahim","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Changi General Hospital, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,4]]},"reference":[{"issue":"11","key":"bib2-20250516","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1093\/qjmed\/hcaa073","article-title":"Atypical femoral fracture with bisphosphonate use","volume":"113","author":"Yano","year":"2020","journal-title":"QJM."},{"key":"bib3-20250516","doi-asserted-by":"crossref","first-page":"104803","DOI":"10.1016\/j.jmbbm.2021.104803","article-title":"Biomechanical mechanisms of atypical femoral fracture","volume":"124","author":"Ural","year":"2021","journal-title":"J Mech Behav Biomed 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