{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:39:09Z","timestamp":1787755149629,"version":"build-2784847793"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec>\n                    <jats:title>Cases:<\/jats:title>\n                    <jats:p>Three consecutive patients (16F, 52F, and 58F) underwent multiextremity amputation with targeted muscle reinnervation and regenerative peripheral nerve interface. Virtual reality (VR) therapy began postoperatively and continued for 6 to 10 weeks as needed, with assessment at 8 months. The patients experienced negligible-to-mild adverse effects (mean Simulator Sickness Questionnaire: 12.5) and reported good usability (System Usability Score: 62.5). Phantom limb pain decreased from 9.5\/10 to 2.3\/10 during VR (p = 0.002).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>These cases demonstrate that VR can be safely and effectively implemented postoperatively following multiextremity amputation, suggesting potential for expanded use even in similarly complex cases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2106\/jbjs.cc.25.00204","type":"journal-article","created":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:00:33Z","timestamp":1760032833000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Immediate Postoperative Virtual Reality Therapy for Phantom Limb Pain in Multiextremity Amputees"],"prefix":"10.2106","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8261-8124","authenticated-orcid":false,"given":"James Tyler","family":"Frix","sequence":"first","affiliation":[{"name":"Atrium Health Musculoskeletal Institute, Charlotte, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8787-378X","authenticated-orcid":false,"given":"Ryan P.","family":"Serbin","sequence":"additional","affiliation":[{"name":"Atrium Health Musculoskeletal Institute, Charlotte, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0161-2211","authenticated-orcid":false,"given":"Madeline G.","family":"Rieker","sequence":"additional","affiliation":[{"name":"Atrium Health Musculoskeletal Institute, Charlotte, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1119-0041","authenticated-orcid":false,"given":"Kyle","family":"Johnsen","sequence":"additional","affiliation":[{"name":"University of Georgia, College of Engineering, Athens, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2918-1359","authenticated-orcid":false,"given":"Ethan","family":"Bowmar","sequence":"additional","affiliation":[{"name":"University of Georgia, College of Engineering, Athens, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7718-7825","authenticated-orcid":false,"given":"Bryan J.","family":"Loeffler","sequence":"additional","affiliation":[{"name":"OrthoCarolina Reconstructive Center for Lost Limbs, Charlotte, North Carolina"},{"name":"OrthoCarolina Research Institute, Charlotte, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7601-8571","authenticated-orcid":false,"given":"R. 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