{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:51:27Z","timestamp":1787755887101,"version":"build-2784847793"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec>\n                    <jats:title>Case:<\/jats:title>\n                    <jats:p>A 49-year-old male smoker with no comorbidities presented with a tibial plafond fracture treated operatively. Complications resulted to an infected nonunion, requiring 20 surgeries over 3 years. Examination revealed a malaligned hypertrophic nonunion with osteomyelitis requiring extensive reconstruction. Deformity was corrected with a Taylor Spatial Frame, followed by the implantation of a biomimetic hematoma scaffold delivering recombinant human bone morphogenetic protein-2 (rhBMP-2) into the debrided defect, alongside Cerement G to control infection. At 6 months, the patient achieved complete bony union without recurrence of infection, allowing Taylor Spatial Frame removal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The biomimetic hematoma enabled successful healing using a low-dose rhBMP-2, highlighting its potential for treatment-resistant nonunions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2106\/jbjs.cc.25.00267","type":"journal-article","created":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T18:08:43Z","timestamp":1755281323000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Biomimetic Hematoma Enables Healing in a Recalcitrant Nonunion With Chronic Osteomyelitis and 20 Prior Surgeries"],"prefix":"10.2106","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-3405-2471","authenticated-orcid":false,"given":"Adam","family":"Maestas","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery, University of Texas Health Science Center San Antonio, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9625-8078","authenticated-orcid":false,"given":"Vaida","family":"Glatt","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, University of Texas Health Science Center San Antonio, Texas"},{"name":"Sam and Ann Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3287-3052","authenticated-orcid":false,"given":"Animesh","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, University of Texas Health Science Center San Antonio, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,7]]},"reference":[{"issue":"2","key":"bib1-20250815","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5704\/MOJ.1907.001","article-title":"Fracture non-union: a review of clinical challenges and future research needs","volume":"13","author":"Stewart","year":"2019","journal-title":"Malays Orthop J."},{"issue":"suppl 2","key":"bib2-20250815","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.injury.2020.11.029","article-title":"Fracture nonunion in long bones: a literature review of risk factors and surgical management","volume":"52","author":"Nicholson","year":"2021","journal-title":"Injury."},{"issue":"11","key":"bib3-20250815","doi-asserted-by":"crossref","first-page":"e162775","DOI":"10.1001\/jamasurg.2016.2775","article-title":"Epidemiology of fracture nonunion in 18 human 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