{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:50:27Z","timestamp":1787755827797,"version":"build-2784847793"},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec>\n                    <jats:title>Case:<\/jats:title>\n                    <jats:p>An 18-year-old man with no significant medical history presented with persistent anterior knee pain. Imaging revealed multifocal marrow-replacing lesions in the distal femur and patella. Open biopsy confirmed the diagnosis of pseudomyogenic hemangioendothelioma. Fluorodeoxyglucose (FDG) positron emission tomography (PET)\/computed tomography showed intense multifocal hypermetabolism (SUVmax 13.8). Surgery was deferred due to morbidity, so the patient was treated with intravenous zoledronic acid, resulting in clinical improvement and sustained radiographic and metabolic response over 18 months (SUVmax reduced to 2.26).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This case highlights a durable radiographic and clinical response to zoledronic acid monotherapy in multifocal pseudomyogenic hemangioendothelioma, supporting its role as a function-preserving systemic therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2106\/jbjs.cc.25.00396","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T19:00:38Z","timestamp":1766084438000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Pseudomyogenic Hemangioendothelioma Treated with Zoledronic Acid"],"prefix":"10.2106","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-1566-557X","authenticated-orcid":false,"given":"Anna G.","family":"McGovern","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery, Stanford University, Stanford, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6896-4349","authenticated-orcid":false,"given":"Nam Q.","family":"Bui","sequence":"additional","affiliation":[{"name":"Department of Oncology, Stanford University, Stanford, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2774-2704","authenticated-orcid":false,"given":"Gregory W.","family":"Charville","sequence":"additional","affiliation":[{"name":"Department of Pathology, Stanford University, Stanford, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9549-7085","authenticated-orcid":false,"given":"Kip E.","family":"Guja","sequence":"additional","affiliation":[{"name":"Department of Radiology, Stanford University, Stanford, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9223-2770","authenticated-orcid":false,"given":"Robert J.","family":"Steffner","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Stanford University, Stanford, California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,10]]},"reference":[{"issue":"2","key":"bib1-20251218","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1097\/PAS.0b013e3181ff0901","article-title":"Pseudomyogenic hemangioendothelioma: a distinctive, often multicentric tumor with indolent 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Paulo)."},{"issue":"5","key":"bib5-20251218","first-page":"e25250","article-title":"Pazopanib as treatment option for pseudomyogenic hemangioendothelioma: a case report","volume":"14","author":"Alhanash","year":"2022","journal-title":"Cureus."},{"issue":"1","key":"bib6-20251218","doi-asserted-by":"crossref","first-page":"153","DOI":"10.33590\/emjoncol\/ERTE7664","article-title":"Effectiveness of vinorelbine in the management of pseudomyogenic hemangioendothelioma: a case report","volume":"12","author":"Toumi","year":"2024","journal-title":"EMJ Oncol."},{"issue":"1","key":"bib7-20251218","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1007\/s11657-022-01062-4","article-title":"Pseudomyogenic hemangioendothelioma with bone and soft tissue involvement with favorable response to pamidronate: a case report and systematic review of the literature","volume":"17","author":"Brance","year":"2022","journal-title":"Arch 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Res."},{"issue":"48","key":"R13-20251218","doi-asserted-by":"crossref","first-page":"e18161","DOI":"10.1097\/MD.0000000000018161","article-title":"Bisphosphonates as a therapeutic choice for multifocal epithelioid hemangioma of bone: A case report","volume":"98","author":"Tang","year":"2019","journal-title":"Medicine"},{"issue":"5","key":"bib11-20251218","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1097\/MPH.0000000000001459","article-title":"Effective use of sirolimus and zoledronic acid for multiosteotic pseudomyogenic hemangioendothelioma of the bone in a child: case report and review of literature","volume":"41","author":"Danforth","year":"2019","journal-title":"J Pediatr Hematol Oncol."},{"key":"bib12-20251218","doi-asserted-by":"crossref","first-page":"115907","DOI":"10.1016\/j.bone.2021.115907","article-title":"The use of bisphosphonates to treat skeletal complications in solid tumours","volume":"147","author":"D'Oronzo","year":"2021","journal-title":"Bone."}],"container-title":["JBJS Case Connector"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.2106\/JBJS.CC.25.00396","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T13:55:16Z","timestamp":1787752516000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.2106\/JBJS.CC.25.00396"}},"subtitle":["A Case Report"],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":13,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.2106\/jbjs.cc.25.00396","relation":{},"ISSN":["2160-3251"],"issn-type":[{"value":"2160-3251","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10]]}}}