{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:19:16Z","timestamp":1787753956276,"version":"build-2784847793"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec>\n                    <jats:title>Case:<\/jats:title>\n                    <jats:p>A 30-year-old woman with type 1 neurofibromatosis presented with enlargement of the right upper extremity. The condition began in childhood and progressed until the limb reached a nonfunctional and burdensome size from elbow to fingertips. Radiographs showed elongated, thinned bones, and CT demonstrated diffuse soft tissue infiltration. Above-elbow amputation was performed. Pathology revealed diffuse neurofibromatosis of skin, subcutaneous tissues, and muscle without malignant change. Postoperatively, she was fitted with an aesthetic prosthesis and reported marked physical and emotional improvement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This case illustrates a rare presentation of massive upper extremity hemihyperplasia. Amputation provided meaningful improvement in quality of life.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2106\/jbjs.cc.25.00501","type":"journal-article","created":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T18:03:50Z","timestamp":1776362630000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Massive Upper Extremity Hemihyperplasia Secondary to Neurofibromatosis"],"prefix":"10.2106","volume":"16","author":[{"given":"Steve K.","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, Hand and Upper Extremity Service, Hospital for Special Surgery, Weill Medical College of Cornell University, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0580-1854","authenticated-orcid":false,"given":"Sreetha","family":"Sidharthan","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Hand and Upper Extremity Service, Hospital for Special Surgery, Weill Medical College of Cornell University, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Hausman","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Icahn School of Medicine at Mount Sinai, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin A.","family":"Posner","sequence":"additional","affiliation":[{"name":"The Department of Orthopaedic Surgery, The NYU\u2014Langone Orthopedic Hospital\/The New York University Grossman School of Medicine, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,4]]},"reference":[{"issue":"3","key":"bib1-20260416","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1097\/01.bpo.0000217719.10728.39","article-title":"Neurofibromatosis update","volume":"26","author":"Crawford","year":"2006","journal-title":"J Pediatr Orthop."},{"issue":"5","key":"bib2-20260416","first-page":"1573","article-title":"International consensus statement on malignant peripheral nerve sheath tumors in neurofibromatosis","volume":"62","author":"Ferner","year":"2002","journal-title":"Cancer Res."},{"issue":"9","key":"bib3-20260416","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1007\/BF02730728","article-title":"Neurofibromatosis type I: spinal neoplasia without symptoms","volume":"71","author":"Gulati","year":"2004","journal-title":"Indian J Pediatr."},{"issue":"6","key":"bib4-20260416","doi-asserted-by":"crossref","first-page":"3709","DOI":"10.3892\/ol.2016.4469","article-title":"Giant elephantiasis neuromatosa in the setting of neurofibromatosis type 1: a case report","volume":"11","author":"Ponti","year":"2016","journal-title":"Oncol Lett."},{"issue":"3","key":"bib5-20260416","first-page":"146","article-title":"Congenital hemihypertrophy with neurofibromatosis","volume":"23","author":"Praharaj","year":"1969","journal-title":"Indian J Med Sci."},{"issue":"4","key":"bib6-20260416","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0363-5023(80)80174-2","article-title":"Upper extremity hypertrophy secondary to neurofibromatosis: a case report","volume":"5","author":"Shereff","year":"1980","journal-title":"J Hand Surg Am."},{"issue":"17","key":"bib7-20260416","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1001\/jama.1931.27220430002009a","article-title":"Congenital plexiform neurofibromas and elephantiasis neruomatosa of the right arm and neck (von recklinghausen's disease): Supplementary report","volume":"96","author":"Anzinger","year":"1931","journal-title":"J Am Med Assoc."},{"issue":"5 Pt 1","key":"bib8-20260416","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/S0363-5023(87)80055-2","article-title":"Massive neurofibromatosis of the upper extremity with paralysis","volume":"12","author":"Match","year":"1987","journal-title":"J Hand Surg Am."},{"issue":"2","key":"bib9-20260416","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.epsc.2014.12.005","article-title":"Isolated pediatric hemihyperplasia requiring surgical debulking of the thigh","volume":"3","author":"Schultz","year":"2015","journal-title":"J Pediatr Surg Case Rep."},{"issue":"11","key":"bib10-20260416","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.2106\/00004623-199711000-00016","article-title":"Hemihypertrophy. 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