{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:41:24Z","timestamp":1787755284974,"version":"build-2784847793"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec>\n                    <jats:title>Case:<\/jats:title>\n                    <jats:p>A 37-year-old man presented with multiple fragility fractures and profound weakness. Evaluation revealed hypophosphatemia and an elevated serum fibroblast growth factor-23. A Ga-68 DOTANOC PET-CT localized a phosphaturic mesenchymal tumor in the sphenoid bone. Surgical resection was performed with immunohistochemistry confirming the diagnosis and leading to rapid biochemical normalization. The patient showed progressive fracture healing and made a complete functional recovery by 12 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Intracranial phosphaturic mesenchymal tumors are a rare cause of tumor-induced osteomalacia. This case underscores that in patients with unexplained fractures, systematic serum phosphate testing is critical. Functional imaging is essential for tumor localization, and complete surgical excision is curative.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2106\/jbjs.cc.25.00529","type":"journal-article","created":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T18:00:41Z","timestamp":1780682441000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Diagnostic Challenges in Oncogenic Osteomalacia due to Intracranial Phosphaturic Mesenchymal Tumor"],"prefix":"10.2106","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4087-2316","authenticated-orcid":false,"given":"Singanallur Palanivelayutham","family":"Sivakumar","sequence":"first","affiliation":[{"name":"Department of Orthopaedics and Trauma Surgery, Ganga Medical Centre and Hospital , Coimbatore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3631-0649","authenticated-orcid":false,"given":"Venkatesan","family":"Senthil Kannan","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Trauma Surgery, Ganga Medical Centre and Hospital , Coimbatore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5074-6698","authenticated-orcid":false,"given":"Shyam","family":"Duvuru","sequence":"additional","affiliation":[{"name":"Apollo Speciality Hospital, Madurai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2371-3985","authenticated-orcid":false,"given":"Mahshook","family":"Irfan","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Trauma Surgery, Ganga Medical Centre and Hospital , Coimbatore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1295-136X","authenticated-orcid":false,"given":"Jayaramaraju","family":"Dheenadhayalan","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Trauma Surgery, Ganga Medical Centre and Hospital , Coimbatore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6043-006X","authenticated-orcid":false,"given":"Shanmuganathan","family":"Rajasekaran","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Trauma Surgery, Ganga Medical Centre and Hospital , Coimbatore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,4]]},"reference":[{"key":"bib1-20260605","doi-asserted-by":"crossref","first-page":"17044","DOI":"10.1038\/nrdp.2017.44","article-title":"Tumour-induced 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spectrum","volume":"41","author":"Agaimy","year":"2017","journal-title":"Am J Surg Pathol."},{"issue":"2","key":"bib5-20260605","doi-asserted-by":"crossref","first-page":"e40","DOI":"10.2106\/JBJS.CC.16.00172","article-title":"Oncogenic osteomalacia secondary to a metastatic phosphaturic mesenchymal tumor in the talus: a case report and review of the literature","volume":"7","author":"Aziz","year":"2017","journal-title":"JBJS Case Connect."},{"key":"bib6-20260605","doi-asserted-by":"crossref","first-page":"1116793","DOI":"10.3389\/fendo.2023.1116793","article-title":"Sphenoid sinus is a rare site for tumor-induced osteomalacia: a case report and literature review","volume":"14","author":"Wang","year":"2023","journal-title":"Front Endocrinol (Lausanne)."},{"issue":"6","key":"bib7-20260605","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1210\/jc.2005-2105","article-title":"Sensitivity of fibroblast growth factor 23 measurements in tumor-induced 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Follow-up","volume":"97","author":"Wang","year":"2015","journal-title":"J Bone Joint Surg Am."},{"issue":"4","key":"bib11-20260605","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1002\/jbmr.4233","article-title":"Burosumab for the treatment of tumor-induced osteomalacia","volume":"36","author":"Jan de Beur","year":"2021","journal-title":"J Bone Miner Res."},{"issue":"6","key":"bib12-20260605","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.3390\/jcm13061817","article-title":"Tumour-induced osteomalacia\u2014A long way to the diagnosis facilitated by [68Ga]Ga-DOTATATE PET\/CT","volume":"13","author":"Kunikowska","year":"2024","journal-title":"J Clin Med."}],"container-title":["JBJS Case 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