{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:45:40Z","timestamp":1787755540063,"version":"build-2784847793"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec>\n                    <jats:title>Case:<\/jats:title>\n                    <jats:p>An 18-year-old man with severe hemophilia A (without inhibitors) developed severe left knee deformity after an untreated injury, resulting in wheelchair dependence. He underwent knee arthrodesis under factor VIII cover but developed a postoperative hematoma and inhibitor formation. Following evacuation and treatment with activated prothrombin complex concentrate and recombinant factor VII, solid fusion and pain relief were achieved within 6 months. Three years later, he walks independently with improved Lower Extremity Functional Scale and SF-36 scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Knee arthrodesis remains a viable salvage procedure that restores function and quality of life when joint preservation or total knee arthroplasty is unfeasible, especially in resource-limited settings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2106\/jbjs.cc.25.00624","type":"journal-article","created":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T19:00:29Z","timestamp":1769713229000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Complex Triple Deformity of the Knee Managed with Knee Arthrodesis in a Severe Hemophilia A Patient"],"prefix":"10.2106","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4620-723X","authenticated-orcid":false,"given":"Karthick","family":"Rangasamy","sequence":"first","affiliation":[{"name":"Department of Orthopaedics, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5991-8161","authenticated-orcid":false,"given":"Raj","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0208-5653","authenticated-orcid":false,"given":"Nirmal Raj","family":"Gopinathan","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devendra Kumar","family":"Chouhan","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9495-9789","authenticated-orcid":false,"given":"Arihant","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Clinical Hematology and Medical Oncology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,1]]},"reference":[{"issue":"12","key":"bib1-20260129","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1080\/17474086.2024.2429606","article-title":"Global prophylaxis trends in hemophilia: a macroeconomic analysis and its association with world development indicators","volume":"17","author":"John","year":"2024","journal-title":"Expert Rev Hematol."},{"key":"bib2-20260129","doi-asserted-by":"crossref","first-page":"141","DOI":"10.2147\/JBM.S291536","article-title":"Optimizing haemophilia care in resource-limited countries: current challenges and future prospects","volume":"14","author":"Ndoumba-Mintya","year":"2023","journal-title":"J Blood Med."},{"issue":"8","key":"bib3-20260129","doi-asserted-by":"crossref","first-page":"2447","DOI":"10.3390\/jcm13082447","article-title":"Total knee arthroplasty in people with hemophilia: higher incidence of periprosthetic joint infection and 1-year revision\/re-operation than the general population","volume":"13","author":"Rodriguez-Merchan","year":"2024","journal-title":"J Clin Med."},{"issue":"5","key":"bib4-20260129","doi-asserted-by":"crossref","first-page":"e102624","DOI":"10.1016\/j.rpth.2024.102624","article-title":"The influence of severity of haemophilia on bone mineral density and fracture risk","volume":"8","author":"Ransmann","year":"2024","journal-title":"Res Pract Thromb Haemost."},{"issue":"3","key":"bib5-20260129","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s12288-015-0562-x","article-title":"Management of haemophilia in developing countries: challenges and options","volume":"32","author":"Ghosh","year":"2016","journal-title":"Indian J Hematol Blood Transfus."},{"issue":"4","key":"bib6-20260129","doi-asserted-by":"crossref","first-page":"e275","DOI":"10.1111\/hae.12885","article-title":"Meta-analysis: outcomes of total knee arthroplasty in the haemophilia population","volume":"22","author":"Moore","year":"2016","journal-title":"Haemophilia."},{"issue":"suppl 6","key":"bib7-20260129","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/hae.14046","article-title":"WFH guidelines for the management of hemophilia, 3rd edition","volume":"26","author":"Srivastava","year":"2020","journal-title":"Haemophilia."},{"issue":"3","key":"bib8-20260129","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1111\/hae.14540","article-title":"Osteoporosis management and falls prevention in patients with haemophilia: review of haemophilia guidelines","volume":"28","author":"Petkovic","year":"2022","journal-title":"Haemophilia."},{"issue":"2","key":"bib9-20260129","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1111\/hae.13384","article-title":"The role of sclerostin\/dickkopf-1 and receptor activator of nuclear factor kB ligand\/osteoprotegerin signalling pathways in the development of osteoporosis in patients with haemophilia A and B: a cross-sectional study","volume":"24","author":"Anagnostis","year":"2018","journal-title":"Haemophilia."},{"issue":"8","key":"bib10-20260129","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1302\/0301-620X.92B8.23922","article-title":"Total knee replacement in patients with end-stage haemophilic arthropathy: 25-year results","volume":"92","author":"Goddard","year":"2010","journal-title":"J Bone Joint Surg Br."},{"issue":"10","key":"bib11-20260129","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1111\/j.1538-7836.2011.04467.x","article-title":"Surgery and inhibitor development in hemophilia A: a systematic review","volume":"9","author":"Eckhardt","year":"2011","journal-title":"J Thromb Haemost."},{"issue":"1","key":"bib12-20260129","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1186\/s13018-024-04843-4","article-title":"Incidence and treatment-related risk factors of inhibitor development after intensive FVIII replacement for major orthopaedic surgery in previous treated haemophilia A","volume":"19","author":"Wang","year":"2024","journal-title":"J Orthop Surg Res."}],"container-title":["JBJS Case Connector"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.2106\/JBJS.CC.25.00624","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T13:44:40Z","timestamp":1787751880000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.2106\/JBJS.CC.25.00624"}},"subtitle":["A Case Report"],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":12,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.2106\/jbjs.cc.25.00624","relation":{},"ISSN":["2160-3251"],"issn-type":[{"value":"2160-3251","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]}}}