{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:22:54Z","timestamp":1787754174729,"version":"build-2784847793"},"reference-count":53,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Supplement_1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,2]]},"DOI":"10.2106\/jbjs.g.01478","type":"journal-article","created":{"date-parts":[[2008,2,21]],"date-time":"2008-02-21T15:34:05Z","timestamp":1203608045000},"page":"55-61","source":"Crossref","is-referenced-by-count":10,"title":["Clinical Trial Design in Fracture-Healing Research: Meeting the Challenge"],"prefix":"10.2106","volume":"90","author":[{"given":"Saam","family":"Morshed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohit","family":"Bhandari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20210207","year":"2004","journal-title":"Advanced trauma life support program for doctors student manual. 7th ed."},{"key":"R2-20210207","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1056\/NEJM200001203420301","volume":"342","year":"2000","journal-title":"N Engl J Med"},{"key":"R3-20210207","journal-title":"Global health in the 21st century"},{"key":"R4-20210207","first-page":"93","volume":"8","year":"2004","journal-title":"Indian Journal of Critical Care Medicine"},{"key":"R5-20210207","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1056\/NEJM200006223422507","volume":"342","year":"2000","journal-title":"N Engl J Med"},{"key":"R6-20210207","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0895-4356(97)00243-6","volume":"51","year":"1998","journal-title":"J Clin Epidemiol"},{"key":"R7-20210207","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1001\/archinte.1983.00350040143020","volume":"143","year":"1983","journal-title":"Arch Intern Med"},{"key":"R8-20210207","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1136\/bmj.317.7167.1185","volume":"317","year":"1998","journal-title":"BMJ"},{"key":"R9-20210207","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0002-9343(82)90815-4","volume":"72","year":"1982","journal-title":"Am J Med"},{"key":"R10-20210207","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1001\/jama.1995.03530220066035","volume":"274","year":"1995","journal-title":"JAMA"},{"key":"R11-20210207","year":"1996","journal-title":"Guide to clinical preventive services: report of the U.S. Preventive Services Task Force. 2nd ed."},{"key":"R12-20210207","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1001\/jama.1993.03510170083036","volume":"270","year":"1993","journal-title":"JAMA"},{"key":"R13-20210207","doi-asserted-by":"crossref","first-page":"2420","DOI":"10.1001\/jama.1992.03490170092032","volume":"268","year":"1992","journal-title":"JAMA"},{"key":"R14-20210207","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S0140-6736(95)92781-6","volume":"346","year":"1995","journal-title":"Lancet"},{"key":"R15-20210207","first-page":"1220","volume":"84","year":"1997","journal-title":"Br J Surg"},{"key":"R16-20210207","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1002\/bjs.1800800807","volume":"80","year":"1993","journal-title":"Br J Surg"},{"key":"R17-20210207","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1136\/bmj.324.7351.1448","volume":"324","year":"2002","journal-title":"BMJ"},{"key":"R18-20210207","first-page":"550","volume":"89","year":"2007","journal-title":"J Bone Joint Surg Am"},{"key":"R19-20210207","doi-asserted-by":"crossref","first-page":"388","DOI":"10.2106\/00004623-200203000-00009","volume":"84","year":"2002","journal-title":"J Bone Joint Surg Am"},{"key":"R20-20210207","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1056\/NEJMsb021025","volume":"347","year":"2002","journal-title":"N Engl J Med"},{"key":"R21-20210207","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1097\/00000658-200202000-00021","volume":"235","year":"2002","journal-title":"Ann Surg"},{"key":"R22-20210207","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1136\/bmj.330.7482.88","volume":"330","year":"2005","journal-title":"BMJ"},{"key":"R23-20210207","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1097\/00005131-200209000-00004","volume":"16","year":"2002","journal-title":"J Orthop Trauma"},{"key":"R24-20210207","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1302\/0301-620X.84B1.0840015","volume":"84","year":"2002","journal-title":"J Bone Joint Surg Br"},{"key":"R25-20210207","first-page":"295","volume":"160","year":"1981","journal-title":"Clin Orthop Relat Res"},{"key":"R26-20210207","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.3928\/0147-7447-20021201-14","volume":"25","year":"2002","journal-title":"Orthopedics"},{"key":"R27-20210207","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S0039-6060(05)80359-9","volume":"118","year":"1995","journal-title":"Surgery"},{"key":"R28-20210207","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/S0197-2456(03)00136-3","volume":"24","year":"2003","journal-title":"Control Clin Trials"},{"key":"R29-20210207","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/1471-2288-6-44","volume":"6","year":"2006","journal-title":"BMC Med Res Methodol"},{"key":"R30-20210207","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.2106\/00004623-200111000-00005","volume":"83","year":"2001","journal-title":"J Bone Joint Surg Am"},{"key":"R31-20210207","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.2106\/00004623-200212000-00001","volume":"84","year":"2002","journal-title":"J Bone Joint Surg Am"},{"key":"R32-20210207","first-page":"218","volume":"87","year":"2005","journal-title":"J Bone Joint Surg Am"},{"key":"R33-20210207","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.2106\/00004623-200311000-00010","volume":"85","year":"2003","journal-title":"J Bone Joint Surg Am"},{"key":"R34-20210207","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1302\/0301-620X.82B6.0820856","volume":"82","year":"2000","journal-title":"J Bone Joint Surg Br"},{"key":"R35-20210207","doi-asserted-by":"crossref","first-page":"961","DOI":"10.2106\/00004623-199707000-00002","volume":"79","year":"1997","journal-title":"J Bone Joint Surg Am"},{"key":"R36-20210207","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1097\/00005131-199905000-00005","volume":"13","year":"1999","journal-title":"J Orthop Trauma"},{"key":"R37-20210207","doi-asserted-by":"crossref","first-page":"26","DOI":"10.2106\/00004623-199401000-00004","volume":"76","year":"1994","journal-title":"J Bone Joint Surg Am"},{"key":"R38-20210207","doi-asserted-by":"crossref","first-page":"S151","DOI":"10.2106\/00004623-200100022-00013","volume":"83","year":"2001","journal-title":"J Bone Joint Surg Am"},{"key":"R39-20210207","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.2106\/00004623-200607000-00002","volume":"88","year":"2006","journal-title":"J Bone Joint Surg Am"},{"key":"R40-20210207","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.injury.2006.04.130","volume":"37","year":"2006","journal-title":"Injury"},{"key":"R41-20210207","first-page":"531","volume":"1","year":"1959","journal-title":"Lancet"},{"key":"R42-20210207","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1136\/jech.44.3.241","volume":"44","year":"1990","journal-title":"J Epidemiol Community Health"},{"key":"R43-20210207","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/S0020-1383(97)00144-7","volume":"28","year":"1997","journal-title":"Injury"},{"key":"R44-20210207","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/0020-1383(90)90085-9","volume":"21","year":"1990","journal-title":"Injury"},{"key":"R45-20210207","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1302\/0301-620X.80B2.0800243","volume":"80","year":"1998","journal-title":"J Bone Joint Surg Br"},{"key":"R46-20210207","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/S8756-3282(01)00614-7","volume":"29","year":"2001","journal-title":"Bone"},{"key":"R47-20210207","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1007\/s00198-004-1702-6","volume":"16","year":"2005","journal-title":"Osteoporos Int"},{"key":"R48-20210207","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1359\/JBMR.040109","volume":"19","year":"2004","journal-title":"J Bone Miner Res"},{"key":"R49-20210207","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1007\/s00198-005-2031-0","volume":"16","year":"2005","journal-title":"Osteoporos Int"},{"key":"R50-20210207","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.1007\/s00198-004-1696-0","volume":"16","year":"2005","journal-title":"Osteoporos Int"},{"key":"R51-20210207","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.arth.2005.02.001","volume":"20","year":"2005","journal-title":"J Arthroplasty"},{"key":"R52-20210207","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.2106\/00004623-200606000-00007","volume":"88","year":"2006","journal-title":"J Bone Joint Surg Am"},{"key":"R53-20210207","first-page":"26","volume":"88","year":"2006","journal-title":"J Bone Joint Surg Br"}],"container-title":["Journal of Bone and Joint Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00004623-200802001-00011","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T13:23:47Z","timestamp":1787750627000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00004623-200802001-00011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,2]]},"references-count":53,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2008]]}},"URL":"https:\/\/doi.org\/10.2106\/jbjs.g.01478","relation":{},"ISSN":["0021-9355","1535-1386"],"issn-type":[{"value":"0021-9355","type":"print"},{"value":"1535-1386","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,2]]}}}