{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:25:17Z","timestamp":1787754317632,"version":"build-2784847793"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,4,16]]},"DOI":"10.2106\/jbjs.m.00666","type":"journal-article","created":{"date-parts":[[2014,4,16]],"date-time":"2014-04-16T15:53:33Z","timestamp":1397663613000},"page":"617-623","source":"Crossref","is-referenced-by-count":22,"title":["rhBMP Use in Cervical Spine Surgery: Associated Factors and In-Hospital Complications"],"prefix":"10.2106","volume":"96","author":[{"given":"Amit","family":"Jain","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamid","family":"Hassanzadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia A.","family":"Strike","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard L.","family":"Skolasky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee H.","family":"Riley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"issue":"5","key":"bib7-20210131","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1097\/00024720-200210000-00001","article-title":"Anterior lumbar interbody fusion using rhBMP-2 with tapered interbody cages","volume":"15","year":"2002 Oct","journal-title":"J Spinal Disord Tech."},{"issue":"6","key":"bib8-20210131","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.2106\/JBJS.H.00200","article-title":"Clinical and radiographic analysis of an optimized rhBMP-2 formulation as an autograft replacement in posterolateral lumbar spine arthrodesis","volume":"91","year":"2009 Jun","journal-title":"J Bone Joint Surg Am."},{"issue":"1","key":"bib9-20210131","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.spinee.2006.06.381","article-title":"Posterolateral lumbar spine fusion with INFUSE bone graft","volume":"7","year":"2007 Jan-Feb","journal-title":"Spine J."},{"issue":"17","key":"bib10-20210131","first-page":"S110","article-title":"Use of bone morphogenetic protein-2 for adult spinal deformity","volume":"30","year":"2005 Sep 1","journal-title":"Spine (Phila Pa 1976)."},{"issue":"26","key":"bib11-20210131","doi-asserted-by":"crossref","first-page":"2850","DOI":"10.1097\/BRS.0b013e31818a314d","article-title":"The safety and efficacy of OP-1 (rhBMP-7) as a replacement for iliac crest autograft in posterolateral lumbar arthrodesis: a long-term (>4 years) pivotal study","volume":"33","year":"2008 Dec 15","journal-title":"Spine (Phila Pa 1976)."},{"issue":"22","key":"bib12-20210131","doi-asserted-by":"crossref","first-page":"2534","DOI":"10.1097\/01.brs.0000240715.78657.81","article-title":"Clinical outcomes and fusion success at 2 years of single-level instrumented posterolateral fusions with recombinant human bone morphogenetic protein-2\/compression resistant matrix versus iliac crest bone graft","volume":"31","year":"2006 Oct 15","journal-title":"Spine (Phila Pa 1976)."},{"issue":"6","key":"bib13-20210131","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1007\/s00586-008-0648-3","article-title":"Donor site morbidity following iliac crest bone harvesting for cervical fusion: a comparison between minimally invasive and open techniques","volume":"17","year":"2008 Jun","journal-title":"Eur Spine J."},{"issue":"1","key":"bib14-20210131","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1001\/jama.2009.956","article-title":"Prevalence, complications, and hospital charges associated with use of bone-morphogenetic proteins in spinal fusion procedures","volume":"302","year":"2009 Jul 1","journal-title":"JAMA."},{"issue":"19","key":"bib15-20210131","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1097\/BRS.0b013e3181ecf6e4","article-title":"Off-label use of bone morphogenetic proteins in the United States using administrative data","volume":"35","year":"2010 Sep 1","journal-title":"Spine (Phila Pa 1976)."},{"issue":"3","key":"bib16-20210131","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.spinee.2006.12.006","article-title":"Prospective nonrandomized comparison of an allograft with bone morphogenic protein versus an iliac-crest autograft in anterior cervical discectomy and fusion","volume":"8","year":"2008 May-Jun","journal-title":"Spine J."},{"issue":"13","key":"bib17-20210131","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1097\/BRS.0b013e3181a2da08","article-title":"Perioperative complications of recombinant human bone morphogenetic protein-2 on an absorbable collagen sponge versus iliac crest bone graft for posterior cervical arthrodesis","volume":"34","year":"2009 Jun 1","journal-title":"Spine (Phila Pa 1976)."},{"issue":"9","key":"bib18-20210131","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1097\/BRS.0b013e31819e334a","article-title":"Is it safe to use recombinant human bone morphogenetic protein in posterior cervical fusion?","volume":"34","year":"2009 Apr 20","journal-title":"Spine (Phila Pa 1976)."},{"issue":"5","key":"bib19-20210131","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1097\/01.brs.0000201424.27509.72","article-title":"Adverse effects associated with high-dose recombinant human bone morphogenetic protein-2 use in anterior cervical spine fusion","volume":"31","year":"2006 Mar 1","journal-title":"Spine (Phila Pa 1976)."},{"issue":"24","key":"bib20-20210131","doi-asserted-by":"crossref","first-page":"2813","DOI":"10.1097\/01.brs.0000245863.52371.c2","article-title":"Increased swelling complications associated with off-label usage of rhBMP-2 in the anterior cervical spine","volume":"31","year":"2006 Nov 15","journal-title":"Spine (Phila Pa 1976)."},{"issue":"6","key":"bib21-20210131","doi-asserted-by":"crossref","first-page":"529","DOI":"10.3171\/SPI\/2008\/8\/6\/529","article-title":"The safety and efficacy of anterior cervical discectomy and fusion with polyetheretherketone spacer and recombinant human bone morphogenetic protein-2: a review of 200 patients","volume":"8","year":"2008 Jun","journal-title":"J Neurosurg Spine."},{"issue":"8","key":"bib22-20210131","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1097\/BSD.0b013e31815ea897","article-title":"Complications in the use of rhBMP-2 in PEEK cages for interbody spinal fusions","volume":"21","year":"2008 Dec","journal-title":"J Spinal Disord Tech."},{"issue":"15","key":"bib24-20210131","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1097\/BRS.0b013e31828f494c","article-title":"Hospital outcomes and complications of anterior and posterior cervical fusion with bone morphogenic protein","volume":"38","year":"2013 Jul 1","journal-title":"Spine (Phila Pa 1976)."},{"issue":"14","key":"bib26-20210131","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1001\/jama.2012.12929","article-title":"Off-label use of bone morphogenetic proteins in pediatric spinal arthrodesis","volume":"308","year":"2012 Oct 10","journal-title":"JAMA."},{"issue":"4","key":"bib27-20210131","doi-asserted-by":"crossref","first-page":"E274","DOI":"10.1097\/BRS.0b013e3182055a6b","article-title":"Trends in the use of bone morphogenetic protein as a substitute to autologous iliac crest bone grafting for spinal fusion procedures in the United States","volume":"36","year":"2011 Feb 15","journal-title":"Spine (Phila Pa 1976)."},{"issue":"5","key":"bib28-20210131","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0021-9681(87)90171-8","article-title":"A new method of classifying prognostic comorbidity in longitudinal studies: development and validation","volume":"40","year":"1987","journal-title":"J Chronic Dis."},{"issue":"3","key":"bib29-20210131","doi-asserted-by":"crossref","first-page":"318","DOI":"10.3171\/2010.11.SPINE10139","article-title":"Economic impact of comorbidities in spine surgery","volume":"14","year":"2011 Mar","journal-title":"J Neurosurg Spine."},{"issue":"19","key":"bib30-20210131","doi-asserted-by":"crossref","first-page":"E1274","DOI":"10.1097\/BRS.0b013e318206cda3","article-title":"Charlson score is a robust predictor of 30-day complications following spinal metastasis surgery","volume":"36","year":"2011 Sep 1","journal-title":"Spine (Phila Pa 1976)."},{"key":"bib32-20210131","article-title":"Posterior cervical fusion with recombinant human bone morphogenetic protein-2: complications and fusion rate at minimum two-year follow-up","year":"2013 Nov 8","journal-title":"J Spinal Disord Tech."}],"container-title":["Journal of Bone and Joint Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00004623-201404160-00001","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T13:25:47Z","timestamp":1787750747000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00004623-201404160-00001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4,16]]},"references-count":23,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.2106\/jbjs.m.00666","relation":{},"ISSN":["0021-9355","1535-1386"],"issn-type":[{"value":"0021-9355","type":"print"},{"value":"1535-1386","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,16]]}}}