{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:25:56Z","timestamp":1787754356251,"version":"build-2784847793"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"13","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Bone and Joint Surgery"],"published-print":{"date-parts":[[2014,7,2]]},"DOI":"10.2106\/jbjs.m.01097","type":"journal-article","created":{"date-parts":[[2014,7,2]],"date-time":"2014-07-02T15:24:44Z","timestamp":1404314684000},"page":"e107","source":"Crossref","is-referenced-by-count":45,"title":["Effect of Intermittent Administration of Teriparatide (Parathyroid Hormone 1-34) on Bone Morphogenetic Protein-Induced Bone Formation in a Rat Model of Spinal Fusion"],"prefix":"10.2106","volume":"96","author":[{"given":"Tokimitsu","family":"Morimoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Kaito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masafumi","family":"Kashii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohei","family":"Matsuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Sugiura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motoki","family":"Iwasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Yoshikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"issue":"329","key":"bib1-20210131","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1097\/00003086-199608000-00037","article-title":"Complications of iliac crest bone graft harvesting","author":"Arrington","year":"1996","journal-title":"Clin Orthop Relat Res."},{"issue":"13","key":"bib2-20210131","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1097\/00007632-200107010-00018","article-title":"Natural history of posterior iliac crest bone graft donation for spinal surgery: a prospective analysis of morbidity","volume":"26","author":"Robertson","year":"2001","journal-title":"Spine (Phila Pa 1976)."},{"issue":"284","key":"bib3-20210131","first-page":"80","article-title":"Pseudarthrosis of the spine","author":"Steinmann","year":"1992","journal-title":"Clin Orthop Relat Res."},{"issue":"8","key":"bib4-20210131","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1097\/00007632-199306150-00006","article-title":"A prospective, randomized study of lumbar fusion. Preliminary results","volume":"18","author":"Zdeblick","year":"1993","journal-title":"Spine (Phila Pa 1976)."},{"issue":"4885","key":"bib5-20210131","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1126\/science.3201241","article-title":"Novel regulators of bone formation: molecular clones and activities","volume":"242","author":"Wozney","year":"1988","journal-title":"Science."},{"issue":"6","key":"bib6-20210131","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.1073\/pnas.87.6.2220","article-title":"Recombinant human bone morphogenetic protein induces bone formation","volume":"87","author":"Wang","year":"1990","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"3698","key":"bib7-20210131","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1126\/science.150.3698.893","article-title":"Bone: formation by autoinduction","volume":"150","author":"Urist","year":"1965","journal-title":"Science."},{"issue":"5","key":"bib8-20210131","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1097\/01.brs.0000201424.27509.72","article-title":"Adverse effects associated with high-dose recombinant human bone morphogenetic protein-2 use in anterior cervical spine fusion","volume":"31","author":"Shields","year":"2006","journal-title":"Spine (Phila Pa 1976)."},{"issue":"24","key":"bib9-20210131","doi-asserted-by":"crossref","first-page":"2813","DOI":"10.1097\/01.brs.0000245863.52371.c2","article-title":"Increased swelling complications associated with off-label usage of rhBMP-2 in the anterior cervical spine","volume":"31","author":"Smucker","year":"2006","journal-title":"Spine (Phila Pa 1976)."},{"issue":"6","key":"bib10-20210131","first-page":"690","article-title":"Anabolic actions of parathyroid hormone on bone","volume":"14","author":"Dempster","year":"1993","journal-title":"Endocr Rev."},{"issue":"6","key":"bib11-20210131","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1016\/j.bone.2007.03.017","article-title":"Molecular and cellular mechanisms of the anabolic effect of intermittent PTH","volume":"40","author":"Jilka","year":"2007","journal-title":"Bone."},{"issue":"2","key":"bib12-20210131","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1210\/endo-110-2-506","article-title":"Parathyroid hormone stimulates the bone apposition rate independently of its resorptive action: differential effects of intermittent and continuous administration","volume":"110","author":"Tam","year":"1982","journal-title":"Endocrinology."},{"issue":"4","key":"bib13-20210131","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1210\/jc.2009-2677","article-title":"Update in new anabolic therapies for osteoporosis","volume":"95","author":"Canalis","year":"2010","journal-title":"J Clin Endocrinol Metab."},{"issue":"9","key":"bib14-20210131","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1056\/NEJMra067395","article-title":"Mechanisms of anabolic therapies for osteoporosis","volume":"357","author":"Canalis","year":"2007","journal-title":"N Engl J Med."},{"issue":"9","key":"bib15-20210131","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1002\/jbmr.1663","article-title":"Parathyroid hormone induces differentiation of mesenchymal stromal\/stem cells by enhancing bone morphogenetic protein signaling","volume":"27","author":"Yu","year":"2012","journal-title":"J Bone Miner Res."},{"issue":"22","key":"bib16-20210131","doi-asserted-by":"crossref","first-page":"3801","DOI":"10.1242\/dev.025825","article-title":"BMP signaling negatively regulates bone mass through sclerostin by inhibiting the canonical Wnt pathway","volume":"135","author":"Kamiya","year":"2008","journal-title":"Development."},{"issue":"5","key":"bib17-20210131","doi-asserted-by":"crossref","first-page":"905","DOI":"10.2106\/00004623-200305000-00020","article-title":"Effect of regional gene therapy with bone morphogenetic protein-2-producing bone marrow cells on spinal fusion in rats","volume":"85","author":"Wang","year":"2003","journal-title":"J Bone Joint Surg Am."},{"issue":"5","key":"bib18-20210131","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.bone.2007.06.025","article-title":"Enhancement of graft bone healing by intermittent administration of human parathyroid hormone (1-34) in a rat spinal arthrodesis model","volume":"41","author":"Abe","year":"2007","journal-title":"Bone."},{"issue":"1","key":"bib19-20210131","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.spinee.2008.08.009","article-title":"A porcine collagen-derived matrix as a carrier for recombinant human bone morphogenetic protein-2 enhances spinal fusion in rats","volume":"9","author":"Miyazaki","year":"2009","journal-title":"Spine J."},{"issue":"9","key":"bib20-20210131","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1002\/jbm.a.34183","article-title":"In vivo osteogenic response to different ratios of BMP-2 and VEGF released from a biodegradable porous system","volume":"100","author":"Hern\u00e1ndez","year":"2012","journal-title":"J Biomed Mater Res A."},{"issue":"19","key":"bib21-20210131","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1056\/NEJM200105103441904","article-title":"Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis","volume":"344","author":"Neer","year":"2001","journal-title":"N Engl J Med."},{"issue":"3","key":"bib22-20210131","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.orthres.2003.08.018","article-title":"Intermittent parathyroid hormone (1-34) enhances mechanical strength and density of new bone after distraction osteogenesis in rats","volume":"22","author":"Seebach","year":"2004","journal-title":"J Orthop Res."},{"issue":"5","key":"bib23-20210131","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1016\/j.bone.2009.01.370","article-title":"Parathyroid hormone enhances bone morphogenetic protein activity by increasing intracellular 3\u2032, 5\u2032-cyclic adenosine monophosphate accumulation in osteoblastic MC3T3-E1 cells","volume":"44","author":"Nakao","year":"2009","journal-title":"Bone."},{"issue":"12","key":"bib24-20210131","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1055\/s-0029-1233460","article-title":"Parathyroid hormone upregulates BMP-2 mRNA expression through mevalonate kinase and Rho kinase inhibition in osteoblastic MC3T3-E1 cells","volume":"41","author":"Takase","year":"2009","journal-title":"Horm Metab Res."},{"issue":"5034","key":"bib25-20210131","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1126\/science.1658941","article-title":"A G protein-linked receptor for parathyroid hormone and parathyroid hormone-related peptide","volume":"254","author":"J\u00fcppner","year":"1991","journal-title":"Science."},{"issue":"9-10","key":"bib26-20210131","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1089\/ten.tea.2010.0555","article-title":"High doses of bone morphogenetic protein 2 induce structurally abnormal bone and inflammation in vivo","volume":"17","author":"Zara","year":"2011","journal-title":"Tissue Eng Part A."},{"issue":"8","key":"bib27-20210131","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/nrrheum.2009.137","article-title":"Wnt and PPARgamma signaling in osteoblastogenesis and adipogenesis","volume":"5","author":"Takada","year":"2009","journal-title":"Nat Rev Rheumatol."},{"issue":"12","key":"bib28-20210131","doi-asserted-by":"crossref","first-page":"3769","DOI":"10.1089\/ten.tea.2010.0173","article-title":"Enhanced bone morphogenetic protein-2-induced ectopic and orthotopic bone formation by intermittent parathyroid hormone (1-34) administration","volume":"16","author":"Kempen","year":"2010","journal-title":"Tissue Eng Part A."},{"issue":"6","key":"bib29-20210131","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/j.bone.2008.07.251","article-title":"Combined effects of recombinant human BMP-7 (rhBMP-7) and parathyroid hormone (1-34) in metaphyseal bone healing","volume":"43","author":"Morgan","year":"2008","journal-title":"Bone."},{"issue":"9","key":"bib30-20210131","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1002\/jor.20420","article-title":"Effects of OP-1 and PTH in a new experimental model for the study of metaphyseal bone healing","volume":"25","author":"Tsiridis","year":"2007","journal-title":"J Orthop Res."},{"issue":"15","key":"bib31-20210131","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1097\/BRS.0b013e31824ac089","article-title":"Dose-dependent enhancement of spinal fusion in rats with teriparatide (PTH[1-34])","volume":"37","author":"Ming","year":"2012","journal-title":"Spine (Phila Pa 1976)."},{"issue":"3","key":"bib32-20210131","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.bone.2011.05.003","article-title":"Effects of intermittent parathyroid hormone treatment on osteoprogenitor cells in postmenopausal women","volume":"49","author":"Drake","year":"2011","journal-title":"Bone."},{"issue":"4","key":"bib33-20210131","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.bone.2005.02.002","article-title":"Human parathyroid hormone (1-34) accelerates the fracture healing process of woven to lamellar bone replacement and new cortical shell formation in rat femora","volume":"36","author":"Komatsubara","year":"2005","journal-title":"Bone."},{"issue":"4","key":"bib34-20210131","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1097\/00007632-199502001-00003","article-title":"An experimental lumbar intertransverse process spinal fusion model. Radiographic, histologic, and biomechanical healing characteristics","volume":"20","author":"Boden","year":"1995","journal-title":"Spine (Phila Pa 1976)."}],"container-title":["Journal of Bone and Joint Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00004623-201407020-00013","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T13:26:19Z","timestamp":1787750779000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00004623-201407020-00013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,2]]},"references-count":34,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.2106\/jbjs.m.01097","relation":{},"ISSN":["0021-9355","1535-1386"],"issn-type":[{"value":"0021-9355","type":"print"},{"value":"1535-1386","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,2]]}}}