{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:45:46Z","timestamp":1792169146671,"version":"4.4.0"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Bone and Joint Surgery"],"published-print":{"date-parts":[[2014,6,4]]},"DOI":"10.2106\/jbjs.m.01116","type":"journal-article","created":{"date-parts":[[2014,6,4]],"date-time":"2014-06-04T14:00:24Z","timestamp":1401890424000},"page":"897-906","source":"Crossref","is-referenced-by-count":37,"title":["Early Surgical Decompression Restores Neurovascular Blood Flow and Ischemic Parameters in an in Vivo Animal Model of Nerve Compression Injury"],"prefix":"10.2106","volume":"96","author":[{"given":"James","family":"Jung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Hahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tahseen","family":"Mozaffar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranjan","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"issue":"3","key":"bib1-20210131","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1053\/jhsu.2001.24972","article-title":"The prevalence and characteristics of nerve compression symptoms in the general population","volume":"26","author":"Papanicolaou","year":"2001","journal-title":"J Hand Surg Am."},{"issue":"4","key":"bib2-20210131","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/S0749-0712(21)00354-1","article-title":"Carpal tunnel syndrome","volume":"12","author":"von Schroeder","year":"1996","journal-title":"Hand Clin."},{"issue":"11","key":"bib3-20210131","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.2106\/00004623-199311000-00002","article-title":"A self-administered questionnaire for the assessment of severity of symptoms and functional status in carpal tunnel syndrome","volume":"75","author":"Levine","year":"1993","journal-title":"J Bone Joint Surg Am."},{"issue":"10","key":"bib4-20210131","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1001\/jama.288.10.1245","article-title":"Splinting vs surgery in the treatment of carpal tunnel syndrome: a randomized controlled trial","volume":"288","author":"Gerritsen","year":"2002","journal-title":"JAMA."},{"issue":"4","key":"bib5-20210131","first-page":"CD001552","article-title":"Surgical versus non-surgical treatment for carpal tunnel syndrome","author":"Verdugo","year":"2008","journal-title":"Cochrane Database Syst Rev."},{"issue":"9695","key":"bib6-20210131","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1016\/S0140-6736(09)61517-8","article-title":"Surgery versus non-surgical therapy for carpal tunnel syndrome: a randomised parallel-group trial","volume":"374","author":"Jarvik","year":"2009","journal-title":"Lancet."},{"issue":"10","key":"bib7-20210131","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1046\/j.0007-1323.2001.01858.x","article-title":"Systematic review of randomized clinical trials of surgical treatment for carpal tunnel syndrome","volume":"88","author":"Gerritsen","year":"2001","journal-title":"Br J Surg."},{"issue":"5-6","key":"bib8-20210131","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.wneu.2012.08.008","article-title":"Early versus delayed endoscopic surgery for carpal tunnel syndrome: prospective randomized study","volume":"79","author":"Chandra","year":"2013","journal-title":"World Neurosurg."},{"issue":"4","key":"bib9-20210131","first-page":"CD003905","article-title":"Surgical treatment options for carpal tunnel syndrome","author":"Scholten","year":"2007","journal-title":"Cochrane Database Syst Rev."},{"issue":"8","key":"bib10-20210131","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1002\/1097-4598(200008)23:8<1160::AID-MUS2>3.0.CO;2-4","article-title":"Surgical treatment of common entrapment neuropathies in the upper limbs","volume":"23","author":"Arle","year":"2000","journal-title":"Muscle Nerve."},{"issue":"1","key":"bib11-20210131","doi-asserted-by":"crossref","first-page":"e2","DOI":"10.3171\/foc.1997.3.1.5","article-title":"The role of electrodiagnostic testing in carpal tunnel syndrome","volume":"3","author":"Phillips","year":"1997","journal-title":"Neurosurg Focus."},{"issue":"10","key":"bib12-20210131","doi-asserted-by":"crossref","first-page":"2478","DOI":"10.2106\/JBJS.I.00643","article-title":"American Academy of Orthopaedic Surgeons clinical practice guideline on diagnosis of carpal tunnel syndrome","volume":"91","author":"Keith","year":"2009","journal-title":"J Bone Joint Surg Am."},{"issue":"3","key":"bib13-20210131","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1089\/neu.2009.1025","article-title":"The microvascular impact of focal nerve trunk injury","volume":"27","author":"Xu","year":"2010","journal-title":"J Neurotrauma."},{"issue":"2","key":"bib14-20210131","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.orthres.2004.08.026","article-title":"Effect of acute nerve root compression on endoneurial fluid pressure and blood flow in rat dorsal root ganglia","volume":"23","author":"Igarashi","year":"2005","journal-title":"J Orthop Res."},{"issue":"2","key":"bib15-20210131","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1002\/cne.10692","article-title":"Chronic nerve compression induces concurrent apoptosis and proliferation of Schwann cells","volume":"461","author":"Gupta","year":"2003","journal-title":"J Comp Neurol."},{"issue":"3","key":"bib16-20210131","doi-asserted-by":"crossref","first-page":"179","DOI":"10.3109\/02844317709025516","article-title":"Permeability of intraneural microvessels and perineurium following acute, graded experimental nerve compression","volume":"11","author":"Rydevik","year":"1977","journal-title":"Scand J Plast Reconstr Surg."},{"issue":"1","key":"bib17-20210131","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0363-5023(81)80003-2","article-title":"Effects of graded compression on intraneural blood blow. An in vivo study on rabbit tibial nerve","volume":"6","author":"Rydevik","year":"1981","journal-title":"J Hand Surg Am."},{"issue":"4","key":"bib18-20210131","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1002\/mus.20272","article-title":"Schwann cells upregulate vascular endothelial growth factor secondary to chronic nerve compression injury","volume":"31","author":"Gupta","year":"2005","journal-title":"Muscle Nerve."},{"issue":"1","key":"bib19-20210131","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1002\/ana.23592","article-title":"Biophysical stimulation induces demyelination via an integrin-dependent mechanism","volume":"72","author":"Lin","year":"2012","journal-title":"Ann Neurol."},{"issue":"6","key":"bib20-20210131","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/S0363-5023(89)80048-6","article-title":"Intraoperative assessment of median nerve blood flow during carpal tunnel release with laser Doppler flowmetry","volume":"14","author":"Seiler","year":"1989","journal-title":"J Hand Surg Am."},{"issue":"2","key":"bib21-20210131","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1002\/mus.22276","article-title":"Chronic nerve compression alters Schwann cell myelin architecture in a murine model","volume":"45","author":"Gupta","year":"2012","journal-title":"Muscle Nerve."},{"issue":"2-3","key":"bib22-20210131","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/0022-510X(86)90109-7","article-title":"Methods for producing a reproducible crush in the sciatic and tibial nerve of the rat and rapid and precise testing of return of sensory function. Beneficial effects of melanocortins","volume":"74","author":"De Koning","year":"1986","journal-title":"J Neurol Sci."},{"issue":"3","key":"bib23-20210131","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.mvr.2011.07.004","article-title":"Wide-field functional imaging of blood flow and hemoglobin oxygen saturation in the rodent dorsal window chamber","volume":"82","author":"Moy","year":"2011","journal-title":"Microvasc Res."},{"issue":"1","key":"bib24-20210131","doi-asserted-by":"crossref","first-page":"016009","DOI":"10.1117\/1.3528610","article-title":"Real-time blood flow visualization using the graphics processing unit","volume":"16","author":"Yang","year":"2011","journal-title":"J Biomed Opt."},{"issue":"2","key":"bib25-20210131","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1002\/ana.23781","article-title":"Matrix metalloproteinase 3 deletion preserves denervated motor endplates after traumatic nerve injury","volume":"73","author":"Chao","year":"2013","journal-title":"Ann Neurol."},{"issue":"5","key":"bib26-20210131","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1038\/sj.sc.3101281","article-title":"Pentoxifylline reduces biochemical markers of ischemia-reperfusion induced spinal cord injury in rabbits","volume":"40","author":"Sava\u015f","year":"2002","journal-title":"Spinal Cord."},{"key":"bib27-20210131","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1471-2202-9-27","article-title":"Alterations in the Notch4 pathway in cerebral endothelial cells by the HIV aspartyl protease inhibitor, nelfinavir","volume":"9","author":"Grigorian","year":"2008","journal-title":"BMC Neurosci."},{"issue":"2","key":"bib28-20210131","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/j.1440-1681.2011.05656.x","article-title":"Hypoxia-inducible factor 1 activation from adipose protein 2-cre mediated knockout of von Hippel-Lindau gene leads to embryonic lethality","volume":"39","author":"Zhang","year":"2012","journal-title":"Clin Exp Pharmacol Physiol."},{"issue":"41","key":"bib29-20210131","doi-asserted-by":"crossref","first-page":"30678","DOI":"10.1074\/jbc.C600120200","article-title":"Differentiation arrest by hypoxia","volume":"281","author":"Lin","year":"2006","journal-title":"J Biol Chem."},{"issue":"9","key":"bib30-20210131","doi-asserted-by":"crossref","first-page":"7468","DOI":"10.1074\/jbc.M110.179242","article-title":"FoxO transcription factors promote cardiomyocyte survival upon induction of oxidative stress","volume":"286","author":"Sengupta","year":"2011","journal-title":"J Biol Chem."},{"issue":"7","key":"bib31-20210131","doi-asserted-by":"crossref","first-page":"3012","DOI":"10.1073\/pnas.0914902107","article-title":"Proliferative lesions and metalloproteinase activity in murine lupus nephritis mediated by type I interferons and macrophages","volume":"107","author":"Triantafyllopoulou","year":"2010","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"12","key":"bib32-20210131","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.2106\/JBJS.L.00903","article-title":"Outcomes of open carpal tunnel release at a minimum of ten years","volume":"95","author":"Louie","year":"2013","journal-title":"J Bone Joint Surg Am."},{"issue":"10","key":"bib34-20210131","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1056\/NEJM199909023411006","article-title":"Cutaneous wound healing","volume":"341","author":"Singer","year":"1999","journal-title":"N Engl J Med."},{"issue":"1","key":"bib35-20210131","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1152\/jappl.1999.86.1.260","article-title":"Prolonged hypoxia increases vascular endothelial growth factor mRNA and protein in adult mouse brain","volume":"86","author":"Kuo","year":"1999","journal-title":"J Appl Physiol (1985)."},{"issue":"1-2","key":"bib36-20210131","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S0006-8993(98)00976-7","article-title":"Hypoxic induction of vascular endothelial growth factor (VEGF) protein in astroglial cultures","volume":"812","author":"Sinor","year":"1998","journal-title":"Brain Res."},{"issue":"11","key":"bib37-20210131","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1002\/mus.880181109","article-title":"Comparison of digital sensory studies in patients with carpal tunnel syndrome","volume":"18","author":"Kothari","year":"1995","journal-title":"Muscle Nerve."},{"issue":"9","key":"bib38-20210131","first-page":"586","article-title":"New criteria for sensory nerve conduction especially useful in diagnosing carpal tunnel syndrome","volume":"67","author":"Di Benedetto","year":"1986","journal-title":"Arch Phys Med Rehabil."},{"issue":"7","key":"bib39-20210131","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1002\/mus.880130707","article-title":"Carpal tunnel syndrome: which finger should be tested? An analysis of sensory conduction in digital branches of the median nerve","volume":"13","author":"Macdonell","year":"1990","journal-title":"Muscle Nerve."},{"issue":"12","key":"bib40-20210131","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1002\/1097-4598(200012)23:12<1880::AID-MUS14>3.0.CO;2-A","article-title":"Optimizing the number of tests for carpal tunnel syndrome","volume":"23","author":"Robinson","year":"2000","journal-title":"Muscle Nerve."}],"container-title":["Journal of Bone and Joint Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00004623-201406040-00004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T13:26:03Z","timestamp":1787750763000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00004623-201406040-00004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,4]]},"references-count":39,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.2106\/jbjs.m.01116","relation":{},"ISSN":["0021-9355","1535-1386"],"issn-type":[{"value":"0021-9355","type":"print"},{"value":"1535-1386","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,4]]}}}