{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:35:43Z","timestamp":1787754943723,"version":"build-2784847793"},"reference-count":114,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JBJS Rev"],"published-print":{"date-parts":[[2016,7,5]]},"abstract":"<jats:p>\n                    <jats:list list-type=\"plain\">\n                      <jats:list-item>\n                        <jats:p>\u27a2 Osteolysis is a process mounted by the host immune system that relies on several variables, including patient-related factors, type of insert material, modes of wear, and implant design.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>\u27a2 Imaging techniques such as radiography, computed tomography (CT) scans, magnetic resonance imaging (MRI), and tomosynthesis aid in diagnosing osteolysis.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>\u27a2 Surgical options for the treatment of osteolysis include the insertion of bone grafts, bone cement, and prosthetic augmentation.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>\u27a2 Although no approved pharmacological therapies for the specific treatment of osteolysis exist, the use of bisphosphonates and statins decreases the risk of osteolysis.<\/jats:p>\n                      <\/jats:list-item>\n                    <\/jats:list>\n                  <\/jats:p>","DOI":"10.2106\/jbjs.rvw.15.00081","type":"journal-article","created":{"date-parts":[[2016,7,5]],"date-time":"2016-07-05T22:59:41Z","timestamp":1467759581000},"source":"Crossref","is-referenced-by-count":10,"title":["Osteolysis Complicating Total Knee Arthroplasty"],"prefix":"10.2106","volume":"4","author":[{"given":"Theodore J.","family":"Gilbert","sequence":"first","affiliation":[{"name":"Division of Orthopaedics and Rehabilitation, Department of Surgery, Southern Illinois University School of Medicine, Springfield, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afshin A.","family":"Anoushiravani","sequence":"additional","affiliation":[{"name":"Division of Orthopaedics and Rehabilitation, Department of Surgery, Southern Illinois University School of Medicine, Springfield, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zain","family":"Sayeed","sequence":"additional","affiliation":[{"name":"Division of Orthopaedics and Rehabilitation, Department of Surgery, Southern Illinois University School of Medicine, Springfield, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique C.","family":"Chambers","sequence":"additional","affiliation":[{"name":"Division 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