{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:52:35Z","timestamp":1790693555076,"version":"4.1.0"},"reference-count":81,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>\n                    <jats:list list-type=\"plain\">\n                      <jats:list-item>\n                        <jats:p>\u00bb Orthopaedic surgeons are sometimes the first specialists encountered by patients with inherited conditions that predispose them to aneurysms. The skeletal features are evident, but the aneurysm is silent. Early recognition of the conditions associated with aneurysms can lead to effective treatment and minimize risks of morbidity and death.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>\u00bb Marfan syndrome is characterized by abnormal fibrillin-1 protein and has a broad range of skeletal manifestations, including scoliosis, hindfoot deformity, arachnodactyly, pectus excavatum or carinatum deformity, dural ectasia, and acetabular protrusio. Aneurysm-associated complications are the leading cause of early morbidity and death in patients with Marfan syndrome.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>\u00bb Ehlers-Danlos syndrome is caused by a disturbance in collagen biosynthesis most commonly resulting in joint hypermobility and skin abnormalities. Among the types of Ehlers-Danlos syndrome, vascular Ehlers-Danlos syndrome presents the highest risk of vascular complications. Clubfoot and joint dislocations are common presenting symptoms in vascular Ehlers-Danlos syndrome.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>\u00bb Loeys-Dietz syndrome is a connective tissue disorder resulting in aortic root dilation and several skeletal manifestations, including scoliosis, cervical malformations, joint contractures, and foot deformities.<\/jats:p>\n                      <\/jats:list-item>\n                    <\/jats:list>\n                  <\/jats:p>","DOI":"10.2106\/jbjs.rvw.19.00122","type":"journal-article","created":{"date-parts":[[2020,6,8]],"date-time":"2020-06-08T19:10:57Z","timestamp":1591643457000},"page":"e0122-e0122","source":"Crossref","is-referenced-by-count":7,"title":["Orthopaedic Conditions Associated with Aneurysms"],"prefix":"10.2106","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5768-3541","authenticated-orcid":false,"given":"Majd","family":"Marrache","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, The Johns Hopkins University, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7786-7030","authenticated-orcid":false,"given":"Peter H.","family":"Byers","sequence":"additional","affiliation":[{"name":"Departments of Pathology and Medicine (Medical Genetics), University of Washington, Seattle, Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2934-6374","authenticated-orcid":false,"given":"Paul D.","family":"Sponseller","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, The Johns Hopkins University, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2020,6]]},"reference":[{"issue":"6","key":"r1-20230808","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.ejcts.2009.01.006","article-title":"Inherited diseases and syndromes leading to aortic aneurysms and dissections","volume":"35","author":"Caglayan","year":"2009","journal-title":"Eur J Cardiothorac Surg"},{"issue":"2","key":"r2-20230808","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1249\/00149619-200204000-00003","article-title":"Marfan syndrome: screening for sudden death in athletes","volume":"1","author":"Glorioso","year":"2002","journal-title":"Curr Sports Med Rep"},{"issue":"9","key":"r4-20230808","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.2106\/JBJS.I.01140","article-title":"Musculoskeletal findings of Loeys-Dietz syndrome","volume":"92","author":"Erkula","year":"2010","journal-title":"J Bone Joint Surg Am"},{"issue":"9","key":"r5-20230808","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.2106\/JBJS.I.00892","article-title":"Improving clinical recognition of Marfan syndrome","volume":"92","author":"Sponseller","year":"2010","journal-title":"J Bone Joint Surg Am"},{"issue":"14","key":"r6-20230808","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1056\/NEJM197904053001406","article-title":"The Marfan syndrome: diagnosis and management","volume":"300","author":"Pyeritz","year":"1979","journal-title":"N Engl J Med"},{"issue":"5","key":"r7-20230808","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1038\/nrcardio.2010.30","article-title":"Marfan syndrome. 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