{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:39:41Z","timestamp":1787755181245,"version":"build-2784847793"},"reference-count":71,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"\n \n \n \u00bb As the novel coronavirus disease 2019 (COVID-19) outbreak continues to grow, with 2.5 million cases and 169,006 deaths as of late April 2020, according to the U.S. Centers for Disease Control and Prevention, orthopaedic surgeons should anticipate the complications of pharmacotherapy, namely osteonecrosis, in the next several years.<\/jats:p>\n <\/jats:list-item>\n \n \u00bb The rate of osteonecrosis in patients with severe acute respiratory syndrome (SARS) treated with high-dose corticosteroids is 5% to 58% and occurs mostly in the first year following the initiation of high-dose corticosteroid therapy.<\/jats:p>\n <\/jats:list-item>\n \n \u00bb Patients who had a cumulative corticosteroid dose of \u22653,000 mg and were treated for >25 days are at the highest risk.<\/jats:p>\n <\/jats:list-item>\n \n \u00bb Screening with serum markers and treating with bisphosphonates, extracorporeal shock wave therapy, hyperbaric oxygen, enoxaparin, and\/or lipo-prostaglandin E1 may be effective means to curb the progression to collapse and the consequent need for joint replacement in these relatively young patients.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>","DOI":"10.2106\/jbjs.rvw.20.00052","type":"journal-article","created":{"date-parts":[[2020,7,21]],"date-time":"2020-07-21T10:07:46Z","timestamp":1595326066000},"page":"e20.00052-e20.00052","source":"Crossref","is-referenced-by-count":13,"title":["Orthopaedic Considerations Following COVID-19"],"prefix":"10.2106","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2514-6431","authenticated-orcid":false,"given":"Manan S.","family":"Patel","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, The Rothman Institute at Thomas Jefferson University, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7199-7261","authenticated-orcid":false,"given":"Michael J.","family":"Gutman","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, The Rothman Institute at Thomas Jefferson University, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3845-7220","authenticated-orcid":false,"given":"Joseph A.","family":"Abboud","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, The Rothman Institute at Thomas Jefferson University, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2020,7]]},"reference":[{"issue":"4","key":"r1-20230807","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1002\/jmv.25681","article-title":"Emerging coronaviruses: genome structure, replication, and pathogenesis","volume":"92","author":"Chen","year":"2020","journal-title":"J Med Virol"},{"issue":"4","key":"r2-20230807","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.2353\/ajpath.2007.061088","article-title":"Pathology and pathogenesis of severe acute respiratory syndrome","volume":"170","author":"Gu","year":"2007","journal-title":"Am J Pathol"},{"issue":"4","key":"r3-20230807","first-page":"277","article-title":"SARS case-fatality rates","volume":"169","author":"Fung","year":"2003","journal-title":"CMAJ"},{"key":"r4-20230807","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.ijid.2020.01.009","article-title":"The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health - the latest 2019 novel coronavirus outbreak in Wuhan, China","volume":"91","author":"Hui","year":"2020","journal-title":"Int J Infect Dis"},{"issue":"10","key":"r5-20230807","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1056\/NEJMoa2001191","article-title":"Washington State 2019-nCoV Case Investigation Team. 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